Search Results - "van Noesel, Max M."
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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Published in Nature (London) (29-03-2012)“…Whole-genome sequencing of neuroblastoma, a childhood tumour of the nervous system, shows that chromothripsis (a local shredding of chromosomes) and mutations…”
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[18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study
Published in European journal of nuclear medicine and molecular imaging (01-03-2023)“… Purpose Meta -[ 18 F]fluorobenzylguanidine ([ 18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging…”
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Imaging features of hepatic sinusoidal obstruction syndrome or veno-occlusive disease in children
Published in Pediatric radiology (01-01-2022)“…Hepatic sinusoidal obstruction syndrome, also known as veno-occlusive disease, can occur as a complication of myeloablative chemotherapy, as a result of…”
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Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
Published in Cancer cell (12-02-2024)“…Pediatric patients with high-risk neuroblastoma have poor survival rates and urgently need more effective treatment options with less side effects. Since novel…”
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Expression and clinical association of programmed cell death-1, programmed death-ligand-1 and CD8 + lymphocytes in primary sarcomas is subtype dependent
Published in Oncotarget (19-09-2017)“…In order to explore the potential of immune checkpoint blockade in sarcoma, we investigated expression and clinical relevance of programmed cell death-1…”
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The Current Status and Future Potential of Theranostics to Diagnose and Treat Childhood Cancer
Published in Frontiers in oncology (19-11-2020)“…In theranostics (i.e., therapy and diagnostics) radiopharmaceuticals are used for both therapeutic and diagnostic purposes by targeting one specific tumor…”
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Neuroblastoma stage 4S: a multifocal stem-cell disease of the developing neural crest
Published in The lancet oncology (01-03-2012)Get full text
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EWSR1—The Most Common Rearranged Gene in Soft Tissue Lesions, Which Also Occurs in Different Bone Lesions: An Updated Review
Published in Diagnostics (Basel) (01-06-2021)“…EWSR1 belongs to the FET family of RNA-binding proteins including also Fused in Sarcoma (FUS), and TATA-box binding protein Associated Factor 15 (TAF15). As…”
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MRI-based inter- and intrafraction motion analysis of the pancreatic tail and spleen as preparation for adaptive MRI-guided radiotherapy in neuroblastoma
Published in Radiation oncology (London, England) (02-10-2023)“…Abstract Background In pediatric radiotherapy treatment planning of abdominal tumors, dose constraints to the pancreatic tail/spleen are applied to reduce late…”
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High Anaplastic Lymphoma Kinase Immunohistochemical Staining in Neuroblastoma and Ganglioneuroblastoma Is an Independent Predictor of Poor Outcome
Published in The American journal of pathology (01-03-2012)“…Anaplastic lymphoma kinase ( ALK ) mutations occur in 3% to 11% of neuroblastoma (NBL) cases and are associated with high ALK levels. However, high ALK levels…”
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MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma
Published in Frontiers in oncology (21-02-2023)“…Mutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition . However, these…”
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EDP-mitotane in children: reassuring evidence of reversible side-effects and neurotoxicity
Published in Discover. Oncology (18-04-2022)“…Adrenocortical carcinoma affects one in 5 million children each year. Since prognosis for children older than 4 years is limited, clinicians often choose…”
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Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies
Published in Head & neck (01-01-2017)“…Background This article reports risk factors and long‐term outcome in localized nonparameningeal head and neck rhabdomyosarcomas in children and adolescents…”
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Treatment at Relapse for Synovial Sarcoma of Children, Adolescents and Young Adults: From the State of Art to Future Clinical Perspectives
Published in Cancer management and research (01-01-2023)“…While the overall prognosis is generally quite satisfactory in children, adolescents and young adults with localised synovial sarcoma at first diagnosis, the…”
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SNP Array Profiling of Childhood Adrenocortical Tumors Reveals Distinct Pathways of Tumorigenesis and Highlights Candidate Driver Genes
Published in The journal of clinical endocrinology and metabolism (01-07-2012)“…Context: Childhood adrenocortical tumors (ACT) are rare malignancies, except in southern Brazil, where a higher incidence rate is associated to a high…”
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Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia
Published in Endocrine-related cancer (01-08-2014)“…Hotspot mutations in the promoter of the telomerase reverse transcriptase (TERT) gene have been recently reported in human cancers and proposed as a novel…”
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A comprehensive overview of liquid biopsy applications in pediatric solid tumors
Published in NPJ precision oncology (03-08-2024)“…Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from…”
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Author Correction: A comprehensive overview of liquid biopsy applications in pediatric solid tumors
Published in NPJ precision oncology (25-09-2024)Get full text
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mRNA Expression Level of ALK in Neuroblastoma Is Associated with Histological Subtype, ALK Mutations and ALK Immunohistochemical Protein Expression
Published in Journal of Molecular Pathology (01-08-2024)“…ALK is related to poor survival in neuroblastoma patients. We investigated the prognostic relevance of ALK mRNA expression and the relationship with ALK…”
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Local staging and treatment in extremity rhabdomyosarcoma. A report from the EpSSG‐RMS2005 study
Published in Cancer medicine (Malden, MA) (01-10-2020)“…Rhabdomyosarcoma of the extremities present with two main challenges: correct evaluation of initial regional nodal involvement and define adequate local…”
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