Search Results - "van Nieuwenhuijze, Annemarie"

Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis by van Nieuwenhuijze, Annemarie E M, van de Loo, Fons A, Walgreen, Birgitte, Bennink, Miranda, Helsen, Monique, van den Bersselaar, Liduine, Wicks, Ian P, van den Berg, Wim B, Koenders, Marije I

“…Type 17 T helper cells and interleukin (IL)-17 play important roles in the pathogenesis of human and murine arthritis. Although there is a clear link between…”
Get full text

The Th17 Pathway as a Therapeutic Target in Rheumatoid Arthritis and Other Autoimmune and Inflammatory Disorders by Roeleveld, Debbie M., van Nieuwenhuijze, Annemarie E. M., van den Berg, Wim B., Koenders, Marije I.

“…Production of the pro-inflammatory cytokine interleukin (IL)-17 by Th17 cells and other cells of the immune system protects the host against bacterial and…”
Get full text

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes by Naik, Shalin H, Shortman, Ken, Metcalf, Donald, van Nieuwenhuijze, Annemarie, Wicks, Ian, Wu, Li, O'Keeffe, Meredith

“…Immediate precursors of the many subtypes of dendritic cells (DCs) remain obscure. Here we purified a splenic precursor population that produced all splenic…”
Get full text

Inflammatory Gene Expression Profile and Defective Interferon‐γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients by Put, Karen, Vandenhaute, Jessica, Avau, Anneleen, van Nieuwenhuijze, Annemarie, Brisse, Ellen, Dierckx, Tim, Rutgeerts, Omer, Garcia‐Perez, Josselyn E., Toelen, Jaan, Waer, Mark, Leclercq, Georges, Goris, An, Van Weyenbergh, Johan, Liston, Adrian, De Somer, Lien, Wouters, Carine H., Matthys, Patrick

“…Objective Systemic juvenile idiopathic arthritis (JIA) is an immunoinflammatory disease characterized by arthritis and systemic manifestations. The role of…”
Get full text

Lpr‐induced systemic autoimmunity is unaffected by mast cell deficiency by Nieuwenhuijze, Annemarie EM, Cauwe, Bénédicte, Klatt, Denise, Humblet‐Baron, Stéphanie, Liston, Adrian

“…The function of mast cells in allergic and organ‐specific autoimmune responses is highly controversial. In the current study, we aimed to dissect the role of…”
Get full text

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development by Kumari, Rupa, Roy, Urbi, Desai, Sagar, Nilavar, Namrata M., Van Nieuwenhuijze, Annemarie, Paranjape, Amita, Radha, Gudapureddy, Bawa, Pushpinder, Srivastava, Mrinal, Nambiar, Mridula, Balaji, Kithiganahalli Narayanaswamy, Liston, Adrian, Choudhary, Bibha, Raghavan, Sathees C.

“…Recombination activating genes (RAGs), consisting of RAG1 and RAG2, are stringently regulated lymphoid-specific genes, which initiate V(D)J recombination in…”
Get full text

GM-CSF as a therapeutic target in inflammatory diseases by van Nieuwenhuijze, Annemarie, Koenders, Marije, Roeleveld, Debbie, Sleeman, Matthew A., van den Berg, Wim, Wicks, Ian P.

“…•GM-CSF is a pro-inflammatory cytokine.•GM-CSF is a key factor in Th17 driven autoimmune inflammatory conditions.•GM-CSF is a therapeutic target for autoimmune…”
Get full text

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment by Hu, Zicheng, Li, Yu, Van Nieuwenhuijze, Annemarie, Selden, Hilary J., Jarrett, Angela M., Sorace, Anna G., Yankeelov, Thomas E., Liston, Adrian, Ehrlich, Lauren I.R.

“…Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection…”
Get full text

Transgenic Expression of GM-CSF in T Cells Causes Disseminated Histiocytosis by van Nieuwenhuijze, Annemarie E, Coghill, Elise, Gray, Daniel, Prato, Sandro, Metcalf, Donald, Alexander, Warren S, Wicks, Ian P

“…Recent studies highlight surprising roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) production by T cells. T-cell–derived GM-CSF is…”
Get full text

GM‐CSF increases cross‐presentation and CD103 expression by mouse CD8+ spleen dendritic cells by Zhan, Yifan, Carrington, Emma M., van Nieuwenhuijze, Annemarie, Bedoui, Sammy, Seah, Shirley, Xu, Yuekang, Wang, Nancy, Mintern, Justine D., Villadangos, Jose A., Wicks, Ian P., Lew, Andrew M.

“…Resident CD8+ DCs perform several functions, including cross‐presenting antigen and rapidly engulfing the Gram‐positive intracellular pathogen Listeria…”
Get full text

Elevated nucleosome levels in systemic inflammation and sepsis by Zeerleder, Sacha, Zwart, Bas, Wuillemin, Walter A., Aarden, Lucien A., Groeneveld, A. B. Johan, Caliezi, Christoph, van Nieuwenhuijze, Annemarie E. M., van Mierlo, Gerard J., Eerenberg, Anke J. M., Lämmle, Bernhard, Hack, C. Erik

Get full text

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations by van Nieuwenhuijze, Annemarie, Burton, Oliver, Lemaitre, Pierre, Denton, Alice E, Cascalho, Ana, Goodchild, Rose E, Malengier-Devlies, Bert, Cauwe, Bénédicte, Linterman, Michelle A, Humblet-Baron, Stephanie, Liston, Adrian

“…The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core…”
Get full text

Elevated nucleosome levels in systemic inflammation and sepsis by Zeerleder, Sacha, Zwart, Bas, Wuillemin, Walter A, Aarden, Lucien A, Groeneveld, A. B Johan, Caliezi, Christoph, van Nieuwenhuijze, Annemarie E. M, van Mierlo, Gerard J, Eerenberg, Anke J. M, Lämmle, Bernhard, Hack, C Erik

“…OBJECTIVEMultiple organ dysfunction syndrome is a frequent complication of severe sepsis and septic shock and has a high mortality. We hypothesized that…”
Get full text

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis by Lawlor, Kate E., Nieuwenhuijze, Annemarie, Parker, Karen L., Drake, Sarah F., Campbell, Ian K., Smith, Scott D., Vince, James E., Strasser, Andreas, Wicks, Ian P.

“…Selective effects of the Bcl‐2 survival pathway on monocyte differentiation and its importance in determining the outcome of autoimmune disease. RA is a…”
Get full text

Critical Role for Granulocyte Colony-Stimulating Factor in Inflammatory Arthritis by Lawlor, Kate E., Campbell, Ian K., Metcalf, Donald, O'Donnell, Kristy, van Nieuwenhuijze, Annemarie, Roberts, Andrew W., Wicks, Ian P.

“…Granulocyte colony-stimulating factor (G-CSF) is a well known regulator of granulopoiesis, but the role of endogenous G-CSF in inflammatory joint disease has…”
Get full text

Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis by Lawlor, Kate E., Smith, Scott D., Nieuwenhuijze, Annemarie, Huang, David C. S., Wicks, Ian P.

“…Relative resistance to the Bcl‐2 family antagonist ABT‐737 in collagen‐induced arthritis may be explained by Mcl‐1 expression in inflammatory leucocytes…”
Get full text

Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice by van Nieuwenhuijze, Annemarie, Dooley, James, Humblet-Baron, Stéphanie, Sreenivasan, Jayasree, Koenders, Marije, Schlenner, Susan M., Linterman, Michelle, Liston, Adrian

“…MicroRNA (miR) are short non-coding RNA sequences of 19–24 nucleotides that regulate gene expression by binding to mRNA target sequences. The miR-29 family of…”
Get full text

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease by Van Horebeek, Lies, Hilven, Kelly, Mallants, Klara, Van Nieuwenhuijze, Annemarie, Kelkka, Tiina, Savola, Paula, Mustjoki, Satu, Schlenner, Susan M, Liston, Adrian, Dubois, Bénédicte, Goris, An

“…Abstract The role of somatic variants in diseases beyond cancer is increasingly being recognized, with potential roles in autoinflammatory and autoimmune…”
Get full text

CCR7 modulates the generation of thymic regulatory T cells by altering the composition of the thymic dendritic cell compartment by Ehrlich, Lauren Ilyse Richie, Hu, Zicheng, Li, Yu, van Nieuwenhuijze, Annemarie, Kessler, Rachel A, Liston, Adrian

“…Abstract Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. Both dendritic cells (DC) and…”
Get full text

The Molecular Control of Regulatory T Cell Induction by van Nieuwenhuijze, Annemarie, Liston, Adrian

“…Regulatory T cells (Tregs) are characterized by the expression of the master transcription factor forkhead box P3 (Foxp3). Although Foxp3 expression is widely…”
Get full text