Search Results - "van Nes, Johan"

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma by van Groningen, Tim, Akogul, Nurdan, Westerhout, Ellen M., Chan, Alvin, Hasselt, Nancy E., Zwijnenburg, Danny A., Broekmans, Marloes, Stroeken, Peter, Haneveld, Franciska, Hooijer, Gerrit K. J., Savci-Heijink, C. Dilara, Lakeman, Arjan, Volckmann, Richard, van Sluis, Peter, Valentijn, Linda J., Koster, Jan, Versteeg, Rogier, van Nes, Johan

“…Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly…”
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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes by Molenaar, Jan J., Koster, Jan, Zwijnenburg, Danny A., van Sluis, Peter, Valentijn, Linda J., van der Ploeg, Ida, Hamdi, Mohamed, van Nes, Johan, Westerman, Bart A., van Arkel, Jennemiek, Ebus, Marli E., Haneveld, Franciska, Lakeman, Arjan, Schild, Linda, Molenaar, Piet, Stroeken, Peter, van Noesel, Max M., Øra, Ingrid, Santo, Evan E., Caron, Huib N., Westerhout, Ellen M., Versteeg, Rogier

“…Whole-genome sequencing of neuroblastoma, a childhood tumour of the nervous system, shows that chromothripsis (a local shredding of chromosomes) and mutations…”
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Developmental regulation of the Hox genes during axial morphogenesis in the mouse by Deschamps, Jacqueline, van Nes, Johan

“…The Hox genes confer positional information to the axial and paraxial tissues as they emerge gradually from the posterior aspect of the vertebrate embryo. Hox…”
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression by Molenaar, Jan J, Domingo-Fernández, Raquel, Ebus, Marli E, Lindner, Sven, Koster, Jan, Drabek, Ksenija, Mestdagh, Pieter, van Sluis, Peter, Valentijn, Linda J, van Nes, Johan, Broekmans, Marloes, Haneveld, Franciska, Volckmann, Richard, Bray, Isabella, Heukamp, Lukas, Sprüssel, Annika, Thor, Theresa, Kieckbusch, Kristina, Klein-Hitpass, Ludger, Fischer, Matthias, Vandesompele, Jo, Schramm, Alexander, van Noesel, Max M, Varesio, Luigi, Speleman, Frank, Eggert, Angelika, Stallings, Raymond L, Caron, Huib N, Versteeg, Rogier, Schulte, Johannes H

“…Jan Molenaar and colleagues show that LIN28B is overexpressed and amplified in human neuroblastomas and that LIN28B regulates let-7 family miRNAs and MYCN…”
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Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification by Valentijn, Linda J, Koster, Jan, Haneveld, Franciska, Aissa, Rachida Ait, van Sluis, Peter, Broekmans, Marloes E. C, Molenaar, Jan J, van Nes, Johan, Versteeg, Rogier

“…Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is…”
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SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry by Decaesteker, Bieke, Louwagie, Amber, Loontiens, Siebe, De Vloed, Fanny, Bekaert, Sarah-Lee, Roels, Juliette, Vanhauwaert, Suzanne, De Brouwer, Sara, Sanders, Ellen, Berezovskaya, Alla, Denecker, Geertrui, D’haene, Eva, Van Haver, Stéphane, Van Loocke, Wouter, Van Dorpe, Jo, Creytens, David, Van Roy, Nadine, Pieters, Tim, Van Neste, Christophe, Fischer, Matthias, Van Vlierberghe, Pieter, Roberts, Stephen S., Schulte, Johannes, Ek, Sara, Versteeg, Rogier, Koster, Jan, van Nes, Johan, Zimmerman, Mark, De Preter, Katleen, Speleman, Frank

“…The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases…”
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Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos by Young, Teddy, Rowland, Jennifer Elizabeth, van de Ven, Cesca, Bialecka, Monika, Novoa, Ana, Carapuco, Marta, van Nes, Johan, de Graaff, Wim, Duluc, Isabelle, Freund, Jean-Noël, Beck, Felix, Mallo, Moises, Deschamps, Jacqueline

“…Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis,…”
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A NOTCH3 Transcriptional Module Induces Cell Motility in Neuroblastoma by VAN NES, Johan, CHAN, Alvin, VAN GRONINGEN, Tim, VAN SLUIS, Peter, KOSTER, Jan, VERSTEEG, Rogier

“…Neuroblastoma is a childhood tumor of the peripheral sympathetic nervous system with an often lethal outcome due to metastatic disease. Migration and…”
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Abstract 2453: Neuroblastoma is bi-phasic and includes classical neuro-epithelial cells and chemo-resistant mesenchymal cells by Versteeg, Rogier, Groningen, Tim van, Valentijn, Linda J., Westerman, Bart A., Molenaar, Jan J., Westerhout, Ellen M., Hamdi, Mohamed, Tytgat, Godelieve A., Koster, Jan, Nes, Johan van

“…Abstract Introduction Most high stage neuroblastoma initially respond to chemotherapy, but ultimately relapse as therapy-resistant tumor. The mechanisms…”
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The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice by van Nes, Johan, de Graaff, Wim, Lebrin, Franck, Gerhard, Markus, Beck, Felix, Deschamps, Jacqueline

“…Caudal related homeobox (Cdx) genes have so far been shown to be important for embryonic axial elongation and patterning in several vertebrate species. We have…”
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Neuroblastoma is composed of two super-enhancer-associated differentiation states by van Groningen, Tim, Koster, Jan, Valentijn, Linda J, Zwijnenburg, Danny A, Akogul, Nurdan, Hasselt, Nancy E, Broekmans, Marloes, Haneveld, Franciska, Nowakowska, Natalia E, Bras, Johannes, van Noesel, Carel J M, Jongejan, Aldo, van Kampen, Antoine H, Koster, Linda, Baas, Frank, van Dijk-Kerkhoven, Lianne, Huizer-Smit, Margriet, Lecca, Maria C, Chan, Alvin, Lakeman, Arjan, Molenaar, Piet, Volckmann, Richard, Westerhout, Ellen M, Hamdi, Mohamed, van Sluis, Peter G, Ebus, Marli E, Molenaar, Jan J, Tytgat, Godelieve A, Westerman, Bart A, van Nes, Johan, Versteeg, Rogier

“…Rogier Versteeg, Johan van Nes and colleagues report that neuroblastomas comprise two cell types, mesenchymal and adrenergic, that have different responses to…”
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Abstract SY24-02: Neuroblastoma: A developmental twist by Versteeg, Rogier, Valentijn, Linda, Koster, Jan, Groningen, Tim van, Hamdi, Mohamed, Westerhout, Ellen, Nes, Johan van

“…Abstract Intra-tumor heterogeneity is considered as a source of drug-resistant cells that can escape therapy and form relapses. Several tumor types display a…”
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Abstract IA10: Neuroblastoma is a biphasic tumor by Versteeg, Rogier, Groningen, Tim van, Koster, Jan, Valentijn, Linda J., Nes, Johan van

“…Abstract Neuroblastoma is a pediatric tumor of the peripheral adrenergic lineage, which is neural crest derived. During embryogenesis cells delaminate from the…”
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TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets by Decaesteker, Bieke, Denecker, Geertrui, Van Neste, Christophe, Dolman, Emmy M., Van Loocke, Wouter, Gartlgruber, Moritz, Nunes, Carolina, De Vloed, Fanny, Depuydt, Pauline, Verboom, Karen, Rombaut, Dries, Loontiens, Siebe, De Wyn, Jolien, Kholosy, Waleed M., Koopmans, Bianca, Essing, Anke H. W., Herrmann, Carl, Dreidax, Daniel, Durinck, Kaat, Deforce, Dieter, Van Nieuwerburgh, Filip, Henssen, Anton, Versteeg, Rogier, Boeva, Valentina, Schleiermacher, Gudrun, van Nes, Johan, Mestdagh, Pieter, Vanhauwaert, Suzanne, Schulte, Johannes H., Westermann, Frank, Molenaar, Jan J., De Preter, Katleen, Speleman, Frank

“…Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive…”
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Abstract 3662: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors by Nes, Johan van, Groningen, Tim van, Valentijn, Linda, Zwijnenburg, Danny, Westerhout, Ellen M., Hamdi, Mohamed, Koster, Jan, Versteeg, Rogier

“…Abstract Background: Cellular identity in development and disease is driven by Core Regulatory Circuitries (CRCs) of lineage transcription factors that…”
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Correction: Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors by Westerhout, Ellen M., Hamdi, Mohamed, Stroeken, Peter, Nowakowska, Natalia E., Lakeman, Arjan, van Arkel, Jennemiek, Hasselt, Nancy E., Blejlevens, Boris, Akogul, Nurdan, Haneveld, Franciska, Chan, Alvin, van Sluis, Peter, Zwijnenburg, Danny, Volckmann, Richard, van Noesel, Carel JM, Adameyko, Igor, van Gronigen, Tim, Koster, Jan, Valentijn, Linda J., van Nes, Johan, Versteeg, Rogier

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Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors by Westerhout, Ellen M, Hamdi, Mohamed, Stroeken, Peter, Nowakowska, Natalia E, Lakeman, Arjan, van Arkel, Jennemiek, Hasselt, Nancy E, Bleijlevens, Boris, Akogul, Nurdan, Haneveld, Franciska, Chan, Alvin, van Sluis, Peter, Zwijnenburg, Danny, Volckmann, Richard, van Noesel, Carel J M, Adameyko, Igor, van Groningen, Tim, Koster, Jan, Valentijn, Linda J, van Nes, Johan, Versteeg, Rogier

“…Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in…”
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Super enhancers define regulatory subtypes and cell identity in neuroblastoma by Gartlgruber, Moritz, Sharma, Ashwini Kumar, Quintero, Andrés, Dreidax, Daniel, Jansky, Selina, Park, Young-Gyu, Kreth, Sina, Meder, Johanna, Doncevic, Daria, Saary, Paul, Toprak, Umut H, Ishaque, Naveed, Afanasyeva, Elena, Wecht, Elisa, Koster, Jan, Versteeg, Rogier, Grünewald, Thomas G P, Jones, David T W, Pfister, Stefan M, Henrich, Kai-Oliver, van Nes, Johan, Herrmann, Carl, Westermann, Frank

“…Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In…”
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Abstract 3876: Active enhancers delineate intra-tumor heterogeneity of developmental states in neuroblastoma by Nes, Johan van, Groningen, Tim van, Valentijn, Linda J., Zwijnenburg, Danny, Molenaar, Jan J., Westerman, Bart A., Westerhout, Ellen M., Hamdi, Mohamed, Tytgat, Godelieve A., Koster, Jan, Versteeg, Rogier

“…Abstract Background: Cellular heterogeneity within tumors is increasingly recognized as a source of therapeutic failure. However, the cis-regulatory landscapes…”
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Abstract PR08: Neuroblastoma is biphasic and includes classical neuroepithelial cells and chemoresistant mesenchymal cells by Versteeg, Rogier, Groningen, Tim van, Westerman, Bart A., Molenaar, Jan J., Westerhout, Ellen M., Hamdi, Mohamed, Tytgat, Godelieve A., Koster, Jan, Nes, Johan van

“…Abstract Introduction: Most high stage neuroblastoma initially respond to chemotherapy, but ultimately relapse as therapy-resistant tumor. The mechanisms…”
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