Search Results - "van Muiswinkel, F L"

Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra by van Muiswinkel, F.L, de Vos, R.A.I, Bol, J.G.J.M, Andringa, G, Jansen Steur, E.N.H, Ross, D, Siegel, D, Drukarch, B

“…Dopamine (DA) autooxidation, and consequent formation of neurotoxic DA-derived quinones and reactive oxygen species, has been implicated in dopaminergic cell…”
Get full text

Inflammation and Alzheimer's Disease: Relationships between Pathogenic Mechanisms and Clinical Expression by Eikelenboom, P., Rozemuller, J.M., van Muiswinkel, F.L.

“…During the past 15 years a variety of inflammatory proteins has been identified in the brains of patients with Alzheimer's disease (AD) postmortem. There is…”
Get full text

Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity by Van Muiswinkel, F L, Veerhuis, R, Eikelenboom, P

“…Activated microglia, often associated with neuritic amyloid plaques in the Alzheimer's disease brain, are likely to contribute to the progression of the…”
Get more information

Zinc amplifies mSOD1-mediated toxicity in a transgenic mouse model of amyotrophic lateral sclerosis by Groeneveld, G.J., de Leeuw van Weenen, J., van Muiswinkel, F.L., Veldman, H., Veldink, J.H., Wokke, J.H.J., Bär, P.R., van den Berg, L.H.

“…Transgenic mice overexpressing the human mutated form (G93A) of Cu,Zn-superoxide dismutase (mSOD1) develop motor neuron degeneration resembling amyotrophic…”
Get full text

Drug treatment of Parkinson’s disease: Time for phase II by Drukarch, Benjamin, van Muiswinkel, Freek L

“…Parkinson’s disease (PD) is a neurodegenerative syndrome for which at present no cure is available; therapy consists mainly of amelioration of the symptoms…”
Get full text

Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor by Veerhuis, Robert, Janssen, Ingrid, De Groot, Corline J.A., Van Muiswinkel, Freek L., Hack, C.Erik, Eikelenboom, Piet

“…Complement activation products C1q, C4c/d, and C3c/d in amyloid plaques in Alzheimer's disease probably result from direct binding and activation of C1 by…”
Get full text

Ovariectomy and 17β-estradiol modulate disease progression of a mouse model of ALS by Groeneveld, G.J., Van Muiswinkel, F.L., Sturkenboom, J.M., Wokke, J.H.J., Bär, P.R., Van den Berg, L.H.

“…The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective…”
Get full text

Acute or chronic administration of okadaic acid to rats induces brain damage rather than Alzheimer-like neuropathology by Van Dam, A.-M., Bol, J.G.J.M., Binnekade, R., Van Muiswinkel, F.L.

“…Two years ago, an interesting paper was published in Neuroscience by Thomas Arendt and colleagues stating that in rats Alzheimer's disease (AD)-like…”
Get full text

Neuroprotection for Parkinson's disease: a new approach for a new millennium by Drukarch, B, van Muiswinkel, F L

“…Parkinson's disease (PD) is the only neurodegenerative disorder in which pharmacological intervention has resulted in a marked decrease in morbidity and a…”
Get more information

Inflammation and Alzheimer’s disease by Akiyama, Haruhiko, Barger, Steven, Barnum, Scott, Bradt, Bonnie, Bauer, Joachim, Cole, Greg M, Cooper, Neil R, Eikelenboom, Piet, Emmerling, Mark, Fiebich, Berndt L, Finch, Caleb E, Frautschy, Sally, Griffin, W.S.T, Hampel, Harald, Hull, Michael, Landreth, Gary, Lue, Lih–Fen, Mrak, Robert, Mackenzie, Ian R, McGeer, Patrick L, O’Banion, M.Kerry, Pachter, Joel, Pasinetti, Guilio, Plata–Salaman, Carlos, Rogers, Joseph, Rydel, Russell, Shen, Yong, Streit, Wolfgang, Strohmeyer, Ronald, Tooyoma, Ikuo, Van Muiswinkel, Freek L, Veerhuis, Robert, Walker, Douglas, Webster, Scott, Wegrzyniak, Beatrice, Wenk, Gary, Wyss–Coray, Tony

“…Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer’s disease (AD) brain, and it does so with the full complexity of local…”
Get full text

Leads for the development of neuroprotective treatment in Parkinson's disease and brain imaging methods for estimating treatment efficacy by Stoof, Johannes C, Winogrodzka, Ania, van Muiswinkel, Freek L, Wolters, Erik Ch, Voorn, Pieter, Groenewegen, Henk J, Booij, J, Drukarch, Benjamin

“…Patients suffering from Parkinson's disease display severe and progressive deficits in motor behavior, predominantly as a consequence of the degeneration of…”
Get full text

Repeated administration of a selective dopamine D2 receptor agonist to 6-OHDA - lesioned rats does not affect the survival and outgrowth of intrastriatal fetal mesencephalic grafts by VAN MUISWINKEL, F. L, BOL, J. G. J. M, RUIJTER, J. M, STOOF, J. C, DRUKARCH, B, STEINBUSCH, H. W. M

“…The objective of the present study was to investigate the effects of chronic activation of dopamine D2 receptors on the development of grafted fetal rat…”
Get full text

Sustained pharmacological inhibition of nitric oxide synthase does not affect the survival of intrastriatal rat fetal mesencephalic transplants by Van Muiswinkel, Freek L, Drukarch, Benjamin, Steinbusch, Harry W.M, De Vente, Jan

“…The objective of the present study was to investigate the potential role of the free radical nitric oxide (NO) in the development of fetal rat mesencephalic…”
Get full text

Chronic dopamine D2 receptor activation does not affect survival and differentiation of cultured dopaminergic neurons: morphological and neurochemical observations by Van Muiswinkel, F L, Drukarch, B, Steinbusch, H W, Stoof, J C

“…Primary cultures of rat ventral mesencephalon were used to elucidate the role of chronic stimulation of dopamine (DA) D2 autoreceptors in the development of…”
Get more information

Astrocyte-Enhanced Neuronal Survival is Mediated by Scavenging of Extracellular Reactive Oxygen Species by Drukarch, Benjamin, Schepens, Eric, Stoof, Johannes C., Langeveld, Cornelis H., Van Muiswinkel, Freek L.

“…The survival of cultured neurons is promoted by the presence of antioxidants or astrocytes. This indicates that extracellular reactive oxygen species (ROS)…”
Get full text

Activation of human macrophages by amyloid-beta is attenuated by astrocytes by Smits, H A, van Beelen, A J, de Vos, N M, Rijsmus, A, van der Bruggen, T, Verhoef, J, van Muiswinkel, F L, Nottet, H S

“…In Alzheimer's disease, neuritic amyloid-beta plaques along with surrounding activated microglia and astrocytes are thought to play an important role in the…”
Get full text

L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells by van Muiswinkel, Freek L, Riemers, Frank M, Peters, Godefridus J, LaFleur, M.Vincent M, Siegel, David, Jongenelen, Cornelis A.M, Drukarch, Benjamin

“…The autooxidation of L-Dopa, a catecholamine used in the symptomatic treatment of Parkinson’s disease, generally yields reactive oxygen species and neurotoxic…”
Get full text

Microglia and neurodegeneration by Rozemuller, J M, van Muiswinkel, F L

Get full text

The amino-terminus of the amyloid-β protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages by Van Muiswinkel, Freek L, Raupp, Sigrid F.A, de Vos, N.Machiel, Smits, Hessel A, Verhoef, Jan, Eikelenboom, Piet, Nottet, Hans S.L.M

“…Here, we show that amyloid-β (Aβ) is capable to prime and activate the respiratory burst of human macrophages. Previously, the N-terminus of Aβ(1–42) has been…”
Get full text

Do nonsteroidal anti-inflammatory drugs have a protective effect against dementia? by Van Muiswinkel, F L, Eikelenboom, P

Get full text