Controversies in the Management of Functional Constipation in Children

Controversies in the Management of Functional Constipation in Children

Purpose of review Functional constipation (FC) in children is a common health problem with reported worldwide prevalence rates up to 32.2%. The majority of children with constipation respond to oral laxative treatment. After 5 years of intensive treatment, however, approximately 50% of children rema...

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Bibliographic Details
Published in:Current gastroenterology reports Vol. 21; no. 6; p. 23
Main Authors: van Mill, M. J., Koppen, I. J. N., Benninga, M. A.
Format: Journal Article
Language:English
Published: New York Springer US 01-06-2019
Springer Nature B.V
Subjects:
Abdomen
Celiac disease
Constipation
Defecation
Dietary fiber
Fecal incontinence
Feces
Gastroenterology
Hypercalcemia
Hypothyroidism
Irritable bowel syndrome
Large Intestine (B Cash and S Khan
Laxatives
Medicine
Medicine & Public Health
Microbiota
Pediatrics
Physiology
Polyethylene glycol
Probiotics
Section Editors
Systematic review
Testing laboratories
Topical Collection on Large Intestine
X-rays
Therapy
Children
Functional constipation
Sacral nerve stimulation
Surgery
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Summary:Purpose of review Functional constipation (FC) in children is a common health problem with reported worldwide prevalence rates up to 32.2%. The majority of children with constipation respond to oral laxative treatment. After 5 years of intensive treatment, however, approximately 50% of children remain symptomatic. To discuss the evidence for new treatments in these children, including pre- and probiotics, pelvic physiotherapy, prucalopride, sacral nerve stimulation, and surgery, and to highlight the controversies surrounding them. Recent findings Pre- and probiotics and prucalopride are not effective in the treatment of childhood constipation. Pelvic physiotherapy and sacral nerve stimulation are promising treatment options but larger trials are needed. Surgery for pediatric constipation is the treatment of last resort. Summary Large, well-designed placebo-controlled trials with proper outcome measures, as suggested by the Rome foundation pediatric subcommittee on clinical trials, are necessary to provide more insight regarding the efficacy of new treatments in childhood constipation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1522-8037
1534-312X
DOI:10.1007/s11894-019-0690-9