Search Results - "van Meurs, J B J"
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Cam Deformity and Acetabular Dysplasia as Risk Factors for Hip Osteoarthritis
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-01-2017)“…Objective Cam deformity and acetabular dysplasia have been recognized as relevant risk factors for hip osteoarthritis (OA) in a few prospective studies with…”
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Intestinal microbiome composition and its relation to joint pain and inflammation
Published in Nature communications (25-10-2019)“…Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by…”
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Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors
Published in Annals of the rheumatic diseases (01-12-2014)“…To develop and validate a prognostic model for incident knee osteoarthritis (KOA) in a general population and determine the value of different risk factor…”
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Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
Published in The Lancet (British edition) (03-05-2008)“…Summary Background Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to…”
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Mild hyponatremia as a risk factor for fractures: The rotterdam study
Published in Journal of bone and mineral research (01-08-2011)“…Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking. We studied whether hyponatremia is associated…”
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Gut microbiome-wide association study of depressive symptoms
Published in Nature communications (06-12-2022)“…Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms…”
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Advanced Glycation End Products (AGEs) in Diet and Skin in Relation to Stool Microbiota: The Rotterdam Study
Published in Nutrients (30-05-2023)“…Advanced glycation end products (AGEs) are involved in age-related diseases, but the interaction of gut microbiota with dietary AGEs (dAGEs) and tissue AGEs in…”
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Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis
Published in JAMA : the journal of the American Medical Association (19-03-2008)“…CONTEXT Mutations in the low-density lipoprotein receptor–related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density…”
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High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly
Published in European journal of endocrinology (01-04-2011)“…ObjectiveTo establish the prevalence of osteoporosis, vertebral fractures (VFs), and non-VFs in acromegaly patients with long-term controlled disease and…”
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10
Diversity, compositional and functional differences between gut microbiota of children and adults
Published in Scientific reports (23-01-2020)“…The gut microbiota has been shown to play diverse roles in human health and disease although the underlying mechanisms have not yet been fully elucidated…”
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Erosive hand osteoarthritis: its prevalence and clinical impact in the general population and symptomatic hand osteoarthritis
Published in Annals of the rheumatic diseases (01-07-2011)“…To estimate the prevalence of erosive hand osteoarthritis (EOA) in the general population and its relation to symptomatic hand osteoarthritis (HOA), hand pain…”
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Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort
Published in Arthritis research & therapy (01-04-2016)“…We aimed to investigate the prognostic value of two biomarkers of tissue inflammation, matrix metalloproteinase-dependent degradation of C-reactive protein…”
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A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data
Published in Genome Biology (21-10-2024)“…MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels are known to impact…”
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Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
Published in Clinical epigenetics (07-02-2017)“…DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA…”
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Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer
Published in Clinical epigenetics (18-06-2018)“…Cutaneous squamous cell carcinoma (cSCC) occurs 65-200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which…”
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DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts
Published in Clinical epigenetics (23-02-2021)“…Type 2 diabetes (T2D) is a heterogeneous disease with well-known genetic and environmental risk factors contributing to its prevalence. Epigenetic mechanisms…”
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17
The Association Between Lumbar Disc Degeneration and Low Back Pain: The Influence of Age, Gender, and Individual Radiographic Features
Published in Spine (Philadelphia, Pa. 1976) (01-03-2010)“…Cross-sectional open population based study (nested in a prospective cohort study). To explore the association of the different individual radiographic…”
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Dissecting the association of autophagy-related genes with cardiovascular diseases and intermediate vascular traits: A population-based approach
Published in PloS one (25-03-2019)“…Autophagy is involved in cellular homeostasis and maintenance and may play a role in cardiometabolic health. We aimed to elucidate the role of autophagy in…”
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Homocysteine and the methylenetetrahydrofolate reductase 677C→T polymorphism in relation to muscle mass and strength, physical performance and postural sway
Published in European journal of clinical nutrition (01-07-2013)“…Background/objectives: Elevated plasma homocysteine has been linked to reduced mobility and muscle functioning in the elderly. The relation of…”
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Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip: a systematic review
Published in Rheumatology (Oxford, England) (01-02-2009)“…Above the age of 50 yrs, the incidence of OA rises steeply in women but less in men, suggesting an association with changes in female hormone levels in the…”
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