Search Results - "van Maanen, M. J."

Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093) by KUPPENS, I. E. L. M, BOSCH, T. M, VAN MAANEN, M. J, ROSING, H, FITZPATRICK, A, BEIJNEN, J. H, SCHELLENS, J. H. M

“…Docetaxel given orally as monotherapy results in low bioavailability of <10%. Previous studies have indicated that the intestinal efflux pump P-glycoprotein…”
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Toxicological results in a fatal and two non-fatal cases of scopolamine-facilitated robberies by Lusthof, K.J, Bosman, I.J, Kubat, B, Vincenten-van Maanen, M.J

“…Highlights • Scopolamine was found unexpectedly in a series of cases of scopolamine-facilitated robberies, by non-targeted analysis. • Scopolamine blood…”
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Pesticides and nitrate in groundwater and rainwater in the Province of Limburg in the Netherlands by VAN MAANEN, J. M. S, DE VAAN, M. A. J, VELDSTRA, A. W. F, HENDRIX, W. P. A. M

“…The purpose of this study was to investigate the occurrence of high levels of pesticides in groundwater and rainwater in The Province of Limburg in The…”
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Mechanism of action of antitumor drug etoposide: a review by van Maanen, J M, Retèl, J, de Vries, J, Pinedo, H M

“…Metabolism studies of the antitumor drug etoposide show the formation of metabolites in the lactone ring, which are probably not important for the drug's…”
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Degradation study of thiotepa in aqueous solutions by van Maanen, M.J, Brandt, A.C, Damen, J.M.A, Beijnen, J.H

“…The degradation of N, N′, N′′-triethylenethiophosphoramide (thiotepa) in aqueous solutions has been investigated over the pH range 1–14. Samples were analyzed…”
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Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry by Kuppens, I. E. L. M., van Maanen, M. J., Rosing, H., Schellens, J. H. M., Beijnen, J. H.

“…An assay for the quantitative determination of docetaxel in human plasma is described. Docetaxel was extracted from the matrix using liquid–liquid extraction…”
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Influence of co-medicated drugs on the biotransformation of thioTEPA to TEPA and thioTEPA-mercapturate by van Maanen, M J, Huitema, A D, Beijen, J H

“…The combination of cyclophosphamide, thioTEPA and carboplatin is used in our Institute for the treatment of breast or germ cell cancer. ThioTEPA inhibits the…”
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Simultaneous quantification of fludarabine and cyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry by Silvertand, L. H. H., Vazvaei, F., Weigl, P., Rosing, H., Hillebrand, M. J. X., van Maanen, M. J., Beijnen, J. H.

“…Fludarabine and cyclophosphamide are anticancer agents mainly used in the treatment of hematologic malignancies. We have developed and validated an assay using…”
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Reproducibility of measurements of mid-upper arm circumference in older persons by Wijnhoven, H. A. H., de Boer, M. R., van Maanen, M. J., van Dongen, D. M., Kraaij, S. F., Smit, T., Visser, M.

“…Background Mid‐upper arm circumference (MUAC) is used as an alternative measure for body mass index to determine thinness in older persons. However, there are…”
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IN VITRO EFFECTS OF COAL FLY ASHES: Hydroxyl Radical Generation, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells by van Maanen, J M, Borm, P J, Knaapen, A, van Herwijnen, M, Schilderman, P A, Smith, K R, Aust, A E, Tomatis, M, Fubini, B

“…Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as…”
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A search for new metabolites of N, N', N-triethylenethiophosphoramide by VAN MAANEN, M. J, TIJHOF, I. M, DAMEN, J. M. A, VERSLUIS, C, VAN DEN BOSCH, J. J. K, HECK, A. J. R, RODENHUIS, S, BEIJNEN, J. H

“…An attempt was made to unravel the metabolic profile of the alkylating agent N,N',N''-triethylenethiophosphoramide (thioTEPA). thioTEPA and its metabolite…”
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Evaluation of fecal mutagenicity and colorectal cancer risk by de Kok, Theo M.C.M, van Maanen, Jan M.S

“…Colorectal cancer is one of the most common internal malignancies in Western society. The cause of this disease appears to be multifactorial and involves…”
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Chemistry, pharmacology and pharmacokinetics of N,N′,N′′ -triethylenethiophosphoramide (ThioTEPA) by Maanen, M.J.van, Smeets, C.J.M., Beijnen, J.H.

“…N,N′,N′′ -triethylenethiophosphoramide (thioTEPA) is a trifunctional alkylating agent with a broad spectrum of antitumour activity developed in the 1950s. The…”
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Liquid chromatographic–mass spectrometric determination of the novel, recently identified thioTEPA metabolite, thioTEPA-mercapturate, in urine by van Maanen, M.J, Beijnen, J.H

“…An assay for the quantitative determination of the mercapturic acid conjugate of N, N′, N″-triethylenethiophosphoramide (thioTEPA-mercapturate) in human urine…”
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Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption by Levallois, P, Ayotte, P, Van Maanen, J.M.S, Desrosiers, T, Gingras, S, Dallinga, J.W, Vermeer, I.T.M, Zee, J, Poirier, G

“…Urinary excretion of volatile nitrosamines was assessed in 59 non-smokers living in a rural county of Québec, Canada. Water and food intakes were measured by…”
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DNA adduct and mutation analysis in white blood cells of smokers and nonsmokers by van Maanen, J M, Maas, L M, Hageman, G, Kleinjans, J C, van Agen, B

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Simultaneous determination of thioTEPA, TEPA and a novel, recently identified thioTEPA metabolite, monochloroTEPA, in urine using capillary gas chromatography by van Maanen, M.J., Doesburg Smits, K., Beijnen, J.H.

“…An assay for the simultaneous quantitative determination of thioTEPA, TEPA and the recently identified metabolite N, N′-diethylene-…”
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Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid by van Maanen, J M, van Dijk, A, Mulder, K, de Baets, M H, Menheere, P C, van der Heide, D, Mertens, P L, Kleinjans, J C

“…We studied the effect of nitrate contamination of drinking water on volume and function of the thyroid in human populations exposed to different nitrate levels…”
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Peroxidation of linoleic, arachidonic and oleic acid in relation to the induction of oxidative DNA damage and cytogenetic effects by de Kok, T M, ten Vaarwerk, F, Zwingman, I, van Maanen, J M, Kleinjans, J C

“…In the present study, the possible role of the polyunsaturated fatty acids linoleic and arachidonic acid in the chemical induction of carcinogenesis has been…”
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Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded ΦX174 DNA by MANS, D. R. A, RETEL, J, VAN MAANEN, J. M. S, LAFLEUR, M. V. M, VAN SCHAIK, M. A, PINEDO, H. M, LANKELMA, J

“…The mechanism of action of the anti-tumour agent etoposide (VP-16-213) could involve its bioactivation to metabolites which can damage DNA. Active metabolites…”
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