Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia

Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and establishing leukemia-supportive interactions with stro...

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Bibliographic Details
Published in:	Frontiers in cell and developmental biology Vol. 11; p. 1005494
Main Authors:	Hughes, Anastasia M, Kuek, Vincent, Oommen, Joyce, Chua, Grace-Alyssa, van Loenhout, Maria, Malinge, Sebastien, Kotecha, Rishi S, Cheung, Laurence C
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 20-01-2023
Subjects:	bone marrow bone marrow microenvironment Cell and Developmental Biology leukemia mesenchymal stem cell pre-B cell acute lymphoblastic leukemia leukemia mesenchymal stem cell bone marrow microenvironment bone marrow pre-B cell acute lymphoblastic leukemia
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Summary:	Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and establishing leukemia-supportive interactions with stromal and immune cells. While previous work has highlighted functional defects in the mesenchymal stem cell (MSC) population from the BMM of acute leukemias, thorough characterization and molecular profiling of MSCs in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, has not been conducted. Here, we investigated the cellular and transcriptome profiles of MSCs isolated from the BMM of an immunocompetent BCR-ABL1 model of B-ALL. Leukemia-associated MSCs exhibited reduced self-renewal capacity and significant changes in numerous molecular signatures, including upregulation of inflammatory signaling pathways. Additionally, we found downregulation of genes involved in extracellular matrix organization and osteoblastogenesis in leukemia-associated MSCs. This study provides cellular and molecular insights into the role of MSCs during B-ALL progression.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Matthew Witkowski, University of Colorado Anschutz Medical Campus, United States Kim Kampen, Maastricht University, Netherlands Edited by: Charles De Bock, Children’s Cancer Institute Australia, Australia This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:	2296-634X 2296-634X
DOI:	10.3389/fcell.2023.1005494