Search Results - "van Lipzig, Marola M.H."

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants by van Groen, Bianca D., van de Steeg, Evita, Mooij, Miriam G., van Lipzig, Marola M.H., de Koning, Barbara A.E., Verdijk, Robert M., Wortelboer, Heleen M., Gaedigk, Roger, Bi, Chengpeng, Leeder, J. Steven, van Schaik, Ron H.N., van Rosmalen, Joost, Tibboel, Dick, Vaes, Wouter H., de Wildt, Saskia N.

“…Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age…”
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Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs by Notenboom, Sylvia, Weigand, Karl M., Proost, Johannes H., van Lipzig, Marola M.H., van de Steeg, Evita, van den Broek, Petra H.H., Greupink, Rick, Russel, Frans G.M., Groothuis, Geny M.M.

“…Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the…”
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Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells by Vaessen, Stefan F C, van Lipzig, Marola M H, Pieters, Raymond H H, Krul, Cyrille A M, Wortelboer, Heleen M, van de Steeg, Evita

“…Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study…”
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A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes by Stevens, Lianne J., van Lipzig, Marola M.H., Erpelinck, Steven L.A., Pronk, Apollo, van Gorp, Joost, Wortelboer, Heleen M., van de Steeg, Evita

“…A majority of the preclinical intestinal screening models do not properly reflect the complex physiology of the human intestinal tract, resulting in low…”
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GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid by van Iersel, Marlou L.P.S, van Lipzig, Marola M.H, Rietjens, Ivonne M.C.M, Vervoort, Jacques, van Bladeren, Peter J

“…Using 1H NMR two diastereoisomers of the ethacrynic acid glutathione conjugate (EASG) as well as ethacrynic acid (EA) could be distinguished and quantified…”
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Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays by Murk, Albertinka J., Legler, Juliette, van Lipzig, Marola M. H., Meerman, John H. N., Belfroid, Angelique C., Spenkelink, Albertus, van der Burg, Bart, Rijs, Gerard B. J., Vethaak, Dick

“…A study was performed to optimize sample preparation and application of three in vitro assays for measuring estrogenic potency in environmental extracts. The…”
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Prediction of Ligand Binding Affinity and Orientation of Xenoestrogens to the Estrogen Receptor by Molecular Dynamics Simulations and the Linear Interaction Energy Method by van Lipzig, Marola M. H, ter Laak, Antonius M, Jongejan, Aldo, Vermeulen, Nico P. E, Wamelink, Mirjam, Geerke, Daan, Meerman, John. H. N

“…Exposure to environmental estrogens has been proposed as a risk factor for disruption of reproductive development and tumorigenesis of humans and wildlife…”
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Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity by van Lipzig, Marola M.H., Vermeulen, Nico P.E., Gusinu, Renato, Legler, Juliette, Frank, Heinz, Seidel, Albrecht, Meerman, John H.N.

“…Metabolism of polycyclic aromatic hydrocarbons (PAHs) has been studied intensively, and potential metabolites with estrogenic activity have been identified…”
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Bioactivation of Dibrominated Biphenyls by Cytochrome P450 Activity to Metabolites with Estrogenic Activity and Estrogen Sulfotransferase Inhibition Capacity by van Lipzig, Marola M. H, Commandeur, Jan N, de Kanter, Frans J. J, Damsten, Micaela C, Vermeulen, Nico P. E, Maat, Evelina, Groot, Ed J, Brouwer, Abraham, Kester, Monique H. A, Visser, Theo J, Meerman, John H. N

“…Exposure of humans and wildlife to xenobiotics, such as halogenated biphenyls, that interfere with the endogenous estrogen balance may lead to endocrine…”
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675 Formation of estrogenic metabolites from polycyclic aromatic hydrocarbons and halogenated biphenyls by cytochrome P450 activity and development of a predictive computational model for binding to the estrogen receptor by Meerman, John H.N., van Lipzig, Marola M.H., ter Laak, A.M., Wamelink, Mirjam, Geerke, Daan, Vermeulen, Nico P.E., Jongejan, Aldo

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The Chemical Interaction between the Estrogen Receptor and Monohydroxybenzo[a]pyrene Derivatives Studied by Fluorescence Line-Narrowing Spectroscopy by Bader, Arjen N, van Dongen, Maarten M, van Lipzig, Marola M. H, Kool, Jeroen, Meerman, John H. N, Ariese, Freek, Gooijer, Cees

“…A novel approach is presented for studying the chemical interaction between receptor binding sites and ligands. Monohydroxylated polyaromatic compounds were…”
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