Search Results - "van Linden, A"

Structure- and function-based design of Plasmodium-selective proteasome inhibitors by Li, Hao, O’Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew

“…Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human…”
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Pesticides in groundwater and drinking water wells: overview of the situation in the Netherlands by Schipper, P.N.M, Vissers, M.J.M

“…In the Netherlands, many of the fresh groundwater resources are vulnerable to pollution. Owing to high population densities and intensive farming practices,…”
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Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia by Porter, C C, Kim, J, Fosmire, S, Gearheart, C M, van Linden, A, Baturin, D, Zaberezhnyy, V, Patel, P R, Gao, D, Tan, A C, DeGregori, J

“…Acute myeloid leukemia (AML) remains a therapeutic challenge despite increasing knowledge about the molecular origins of the disease, as the mechanisms of AML…”
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Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death by Sanman, Laura E, Qian, Yu, Eisele, Nicholas A, Ng, Tessie M, van der Linden, Wouter A, Monack, Denise M, Weerapana, Eranthie, Bogyo, Matthew

“…When innate immune cells such as macrophages are challenged with environmental stresses or infection by pathogens, they trigger the rapid assembly of…”
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Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection by Sanman, Laura E, van der Linden, Wouter A, Verdoes, Martijn, Bogyo, Matthew

“…Cysteine cathepsins are lysosomal proteases involved in regulation of both normal cellular processes and disease. Biochemical studies with peptide substrates…”
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Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality by Van Linden, Annemie A, Baturin, Dmitry, Ford, James B, Fosmire, Susan P, Gardner, Lori, Korch, Christopher, Reigan, Philip, Porter, Christopher C

“…Inhibition of Wee1 is emerging as a novel therapeutic strategy for cancer, and some data suggest that cells with dysfunctional p53 are more sensitive to Wee1…”
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LiGAPS-Beef, a mechanistic model to explore potential and feed-limited beef production 1: model description and illustration by van der Linden, A., van de Ven, G. W. J., Oosting, S. J., van Ittersum, M. K., de Boer, I. J. M.

“…The expected increase in the global demand for livestock products calls for insight in the scope to increase actual production levels across the world. This…”
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LiGAPS-Beef, a mechanistic model to explore potential and feed-limited beef production 2: sensitivity analysis and evaluation of sub-models by van der Linden, A., van de Ven, G. W. J., Oosting, S. J., van Ittersum, M. K., de Boer, I. J. M.

“…The model LiGAPS-Beef (Livestock simulator for Generic analysis of Animal Production Systems – Beef cattle) has been developed to assess potential and…”
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LiGAPS-Beef, a mechanistic model to explore potential and feed-limited beef production 3: model evaluation by van der Linden, A., van de Ven, G. W. J., Oosting, S. J., van Ittersum, M. K., de Boer, I. J. M.

“…LiGAPS-Beef (Livestock simulator for Generic analysis of Animal Production Systems – Beef cattle) is a generic, mechanistic model designed to quantify…”
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Towards Adaptive Grids for Atmospheric Boundary-Layer Simulations by van Hooft, J. Antoon, Popinet, Stéphane, van Heerwaarden, Chiel C., van der Linden, Steven J. A., de Roode, Stephan R., van de Wiel, Bas J. H.

“…We present a proof-of-concept for the adaptive mesh refinement method applied to atmospheric boundary-layer simulations. Such a method may form an attractive…”
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Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites by Hopp, Christine S, Bennett, Brandy L, Mishra, Satish, Lehmann, Christine, Hanson, Kirsten K, Lin, Jing-Wen, Rousseau, Kimberly, Carvalho, Filomena A, van der Linden, Wouter A, Santos, Nuno C, Bogyo, Matthew, Khan, Shahid M, Heussler, Volker, Sinnis, Photini

“…Proteases have been implicated in a variety of developmental processes during the malaria parasite lifecycle. In particular, invasion and egress of the…”
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Clinical impact of 20% worsening on Timed 25-foot Walk and 9-hole Peg Test in multiple sclerosis by Kragt, J J, van der Linden, F AH, Nielsen, J M, Uitdehaag, B MJ, Polman, C H

“…Introduction: Quantitative tests of motor function, like the Timed 25-foot Walk (T25FW) and 9-hole Peg Test (9HPT), are increasingly being applied as outcome…”
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Differential hippocampal gene expression is associated with climate-related natural variation in memory and the hippocampus in food-caching chickadees by Pravosudov, V. V., Roth II, T. C., Forister, M. L., LaDage, L. D., Kramer, R., Schilkey, F., van der Linden, A. M.

“…There is significant and often heritable variation in cognition and its underlying neural mechanisms, yet specific genetic contributions to such variation are…”
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Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination by Guglielmetti, C., Veraart, J., Roelant, E., Mai, Z., Daans, J., Van Audekerke, J., Naeyaert, M., Vanhoutte, G., Delgado y Palacios, R., Praet, J., Fieremans, E., Ponsaerts, P., Sijbers, J., Van der Linden, A., Verhoye, M.

“…Although MRI is the gold standard for the diagnosis and monitoring of multiple sclerosis (MS), current conventional MRI techniques often fail to detect…”
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AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair by Ford, James B, Baturin, Dmitry, Burleson, Tamara M, Van Linden, Annemie A, Kim, Yong-Mi, Porter, Christopher C

“…While some children with acute lymphoblastic leukemia (ALL) have excellent prognoses, the prognosis for adults and children with T cell ALL is more guarded…”
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Genomic monitoring to understand the emergence and spread of Usutu virus in the Netherlands, 2016–2018 by Oude Munnink, B. Bas, Münger, E., Nieuwenhuijse, D. F., Kohl, R., van der Linden, A., Schapendonk, C. M. E., van der Jeugd, H., Kik, M., Rijks, J. M., Reusken, C. B. E. M., Koopmans, M.

“…Usutu virus (USUV) is a mosquito-borne flavivirus circulating in Western Europe that causes die-offs of mainly common blackbirds ( Turdus merula ). In the…”
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Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease by Unger, M. S., Marschallinger, J., Kaindl, J., Höfling, C., Rossner, S., Heneka, Michael T., Van der Linden, A., Aigner, Ludwig

“…Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the Western world and is characterized by a progressive loss of cognitive functions…”
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Increased HDAC Activity and c-MYC Expression Mediate Acquired Resistance to WEE1 Inhibition in Acute Leukemia by Garcia, Tamara B, Uluisik, Rizvan C, van Linden, Annemie A, Jones, Kenneth L, Venkataraman, Sujatha, Vibhakar, Rajeev, Porter, Christopher C

“…WEE1 is a cell cycle and DNA damage response kinase that is emerging as a therapeutic target for cancer. AZD1775 is a small molecule inhibitor of WEE1,…”
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Mapping Ground Water Vulnerability to Pesticide Leaching with a Process-Based Metamodel of EuroPEARL by Tiktak, A, Boesten, J.J.T.I, Linden, A.M.A. van der, Vanclooster, M

“…To support EU policy, indicators of pesticide leaching at the European level are required. For this reason, a metamodel of the spatially distributed European…”
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Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses by Brinkkemper, Mitch, Veth, Tim S., Brouwer, Philip J.M., Turner, Hannah, Poniman, Meliawati, Burger, Judith A., Bouhuijs, Joey H., Olijhoek, Wouter, Bontjer, Ilja, Snitselaar, Jonne L., Caniels, Tom G., van der Linden, Cynthia A., Ravichandran, Rashmi, Villaudy, Julien, van der Velden, Yme U., Sliepen, Kwinten, van Gils, Marit J., Ward, Andrew B., King, Neil P., Heck, Albert J.R., Sanders, Rogier W.

“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses continuous challenges in combating the virus. Here, we describe…”
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