Search Results - "van Lier, Margot GF"

Yield of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndrome by van Lier, Margot GF, Leenen, Celine HM, Wagner, Anja, Ramsoekh, Dewkoemar, Dubbink, Hendrikus J, van den Ouweland, Ans MW, Westenend, Pieter J, de Graaf, Eelco JR, Wolters, Leonieke MM, Vrijland, Wietske W, Kuipers, Ernst J, van Leerdam, Monique E, Steyerberg, Ewout W, Dinjens, Winand NM

“…Although early detection of Lynch syndrome (LS) is important, a considerable proportion of patients with LS remains unrecognized. We aimed to study the yield…”
Get full text

Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers by Geurts-Giele, Willemina RR, Leenen, Celine HM, Dubbink, Hendrikus J, Meijssen, Isabelle C, Post, Edward, Sleddens, Hein FBM, Kuipers, Ernst J, Goverde, Anne, van den Ouweland, Ans MW, van Lier, Margot GF, Steyerberg, Ewout W, van Leerdam, Monique E, Wagner, Anja, Dinjens, Winand NM

“…Lynch syndrome (LS) is caused by germline mutations in mismatch repair (MMR) genes, resulting in microsatellite‐unstable tumours. Approximately 35% of…”
Get full text

A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory by Van Lier, Margot G.F., Wagner, Anja, Van Leerdam, Monique E., Biermann, Katharina, Kuipers, Ernst J., Steyerberg, Ewout W., Dubbink, Hendrikus Jan, Dinjens, Winand N.M.

“…•  Lynch syndrome •  Identification of patients at risk for Lynch syndrome •  Molecular basis of Lynch syndrome and sporadic MMR‐deficient tumours •  Molecular…”
Get full text

Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis by VAN LIER, Margot Gf, KORSSE, Susanne E, MATHUS-VLIEGEN, Elisabeth Mh, KUIPERS, Ernst J, VAN DEN OUWELAND, Ans Mw, VANHEUSDEN, Kathleen, VAN LEERDAM, Monique E, WAGNER, Anja

“…Peutz-Jeghers syndrome (PJS) is a hereditary disorder caused by LKB1 gene mutations, and is associated with considerable morbidity and decreased life…”
Get full text