Search Results - "van Lier, Margot G"

Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance by Korsse, Susanne E, Harinck, Femme, van Lier, Margot G F, Biermann, Katharina, Offerhaus, G Johan A, Krak, Nanda, Looman, Caspar W N, van Veelen, Wendy, Kuipers, Ernst J, Wagner, Anja, Dekker, Evelien, Mathus-Vliegen, Elisabeth M H, Fockens, Paul, van Leerdam, Monique E, Bruno, Marco J

“…Although Peutz-Jeghers syndrome (PJS) is known to be associated with pancreatic cancer (PC), estimates of this risk differ widely. This hampers counselling of…”
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Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers by Geurts-Giele, Willemina RR, Leenen, Celine HM, Dubbink, Hendrikus J, Meijssen, Isabelle C, Post, Edward, Sleddens, Hein FBM, Kuipers, Ernst J, Goverde, Anne, van den Ouweland, Ans MW, van Lier, Margot GF, Steyerberg, Ewout W, van Leerdam, Monique E, Wagner, Anja, Dinjens, Winand NM

“…Lynch syndrome (LS) is caused by germline mutations in mismatch repair (MMR) genes, resulting in microsatellite‐unstable tumours. Approximately 35% of…”
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High cancer risk and increased mortality in patients with Peutz-Jeghers syndrome by van Lier, Margot G F, Westerman, Anne Marie, Wagner, Anja, Looman, Caspar W N, Wilson, J H Paul, de Rooij, Felix W M, Lemmens, Valery E P P, Kuipers, Ernst J, Mathus-Vliegen, Elisabeth M H, van Leerdam, Monique E

“…Peutz-Jeghers syndrome (PJS) is associated with an increased cancer risk. As the determination of optimal surveillance strategies is hampered by wide ranges in…”
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Endoscopic therapy of small-bowel polyps by double-balloon enteroscopy in patients with Peutz-Jeghers syndrome by Gao, Hong, MD, PhD, van Lier, Margot G., MD, Poley, Jan Werner, MD, Kuipers, Ernst J., MD, PhD, van Leerdam, Monique E., MD, PhD, Mensink, Peter B., MD, PhD

“…Background Peutz-Jeghers syndrome (PJS) is a hereditary disorder characterized by mucocutaneous pigmentations and hamartomatous polyps mainly in the small…”
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Yield of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndrome by van Lier, Margot GF, Leenen, Celine HM, Wagner, Anja, Ramsoekh, Dewkoemar, Dubbink, Hendrikus J, van den Ouweland, Ans MW, Westenend, Pieter J, de Graaf, Eelco JR, Wolters, Leonieke MM, Vrijland, Wietske W, Kuipers, Ernst J, van Leerdam, Monique E, Steyerberg, Ewout W, Dinjens, Winand NM

“…Although early detection of Lynch syndrome (LS) is important, a considerable proportion of patients with LS remains unrecognized. We aimed to study the yield…”
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A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory by Van Lier, Margot G.F., Wagner, Anja, Van Leerdam, Monique E., Biermann, Katharina, Kuipers, Ernst J., Steyerberg, Ewout W., Dubbink, Hendrikus Jan, Dinjens, Winand N.M.

“…•  Lynch syndrome •  Identification of patients at risk for Lynch syndrome •  Molecular basis of Lynch syndrome and sporadic MMR‐deficient tumours •  Molecular…”
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Limited diagnostic value of microsatellite instability associated pathology features in colorectal cancer by van Putten, Paul G., van Lier, Margot G. F., Hage, Mariska, Biermann, Katharina, van Rijssel, Reinier H., Westenend, Pieter J., Morreau, Hans, Steyerberg, Ewout W., Dinjens, Winand N. M., Kuipers, Ernst J., van Leerdam, Monique E., van Krieken, J. Han

“…To determine the diagnostic test characteristics and inter-observer variation of pathology features for identifying high microsatellite instability (MSI-H)…”
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Underutilization of microsatellite instability analysis in colorectal cancer patients at high risk for Lynch syndrome by Van Lier, Margot G. F., De Wilt, Johannes H. W., Wagemakers, Jessie J. M. F., Dinjens, Winand N. M., Damhuis, Ronald A. M., Wagner, Anja, Kuipers, Ernst J., Van Leerdam, Monique E.

“…Objective. The revised Bethesda Guidelines were published to improve the efficiency of recognizing Lynch syndrome (LS) by identifying LS-related malignancies…”
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Cost-effectiveness of routine screening for Lynch syndrome in colorectal cancer patients up to 70 years of age by Leenen, Celine H. M., Goverde, Anne, de Bekker-Grob, Esther W., Wagner, Anja, van Lier, Margot G. F., Spaander, Manon C. W., Bruno, Marco J., Tops, Carli M., van den Ouweland, Ans M. W., Dubbink, Hendrikus J., Kuipers, Ernst J., Dinjens, Winand N. M., van Leerdam, Monique E., Steyerberg, Ewout W.

“…Purpose: To assess the cost-effectiveness of routine Lynch syndrome (LS) screening among colorectal cancer (CRC) patients ≤70 years of age. Methods: A…”
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Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years by Leenen, Celine H.M, van Lier, Margot G.F, van Doorn, Helena C, van Leerdam, Monique E, Kooi, Sjarlot G, de Waard, Judith, Hoedemaeker, Robert F, van den Ouweland, Ans M.W, Hulspas, Sanne M, Dubbink, Hendrikus J, Kuipers, Ernst J, Wagner, Anja, Dinjens, Winand N.M, Steyerberg, Ewout W

“…Abstract Objective Lynch syndrome (LS) is a hereditary syndrome that predisposes to multiple malignancies including endometrial cancer (EC). We aimed to…”
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Su1948 Cost-Effectiveness of Routine Screening for Lynch Syndrome in Colorectal Cancer Patients up to 70 Years of Age by Goverde, Anne, Leenen, Celine H, Bekker-de Grob, Esther W, Wagner, Anja, van Lier, Margot G, Spaander, Manon C, Bruno, Marco J, Tops, Carli, Van den Ouweland, Ans, Dubbink, Erik Jan, Kuipers, Ernst J, Dinjens, W, van Leerdam, Monique E, Steyerberg, Ewout W

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Su1080 Limited Diagnostic Value of Microsatellite Instability Associated Pathology Features in Colorectal Cancer by van Putten, Paul G, van Lier, Margot G, Hage, M, Biermann, Katharina, van Rijssel, R, Westenend, Pieter J, Morreau, Hans, Dinjens, W, Kuipers, Ernst J, van Leerdam, Monique, van Krieken, J.H

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Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis by VAN LIER, Margot Gf, KORSSE, Susanne E, MATHUS-VLIEGEN, Elisabeth Mh, KUIPERS, Ernst J, VAN DEN OUWELAND, Ans Mw, VANHEUSDEN, Kathleen, VAN LEERDAM, Monique E, WAGNER, Anja

“…Peutz-Jeghers syndrome (PJS) is a hereditary disorder caused by LKB1 gene mutations, and is associated with considerable morbidity and decreased life…”
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Su1850 Molecular Alterations in Gastrointestinal Carcinomas of Peutz-Jeghers Syndrome Patients by Korsse, Susanne E, van Veelen, Wendy, Biermann, Katharina, van Lier, Margot G, Wagner, Anja, Dekker, Evelien, Offerhaus, Johan, Mathus-Vliegen, Elisabeth M, Kuipers, Ernst J, van Leerdam, Monique

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Mo1208 Pancreatic Cancer Risk in Peutz-Jeghers Patients; Results of a Large Dutch Cohort Study and Implications for Surveillance by Harinck, Femme, Korsse, Susanne E, van Lier, Margot G, Biermann, Katharina, Offerhaus, Johan, Krak, Nanda, Looman, Caspar W, van Veelen, Wendy, Kuipers, Ernst J, Wagner, Anja, Dekker, Evelien, Mathus-Vliegen, Elisabeth M, Fockens, Paul, van Leerdam, Monique, Bruno, Marco J

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Challenges and Pitfalls in Screening for Lynch Syndrome by Molecular Tumor Tissue Analysis by Leenen, Celine H, Dubbink, Erik Jan, van Lier, Margot G, Hulspas, Sanne, Kuipers, Ernst J, van Leerdam, Monique, Wagner, Anja, Dinjens, W

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950 High Intussusception Risk at Young Age in Patients With Peutz-Jeghers Syndrome: Time to Update Surveillance Guidelines? by van Lier, Margot G, Mathus-Vliegen, Elisabeth, Wagner, Anja, van Leerdam, Monique E, Kuipers, Ernst J

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M1052 Quality of Life and Psychological Distress in Patients With Peutz-Jeghers Syndrome by van Lier, Margot G, Vanheusden, K, Mathus-Vliegen, Elisabeth, Kuipers, Ernst J, van Leerdam, Monique E, Wagner, Anja

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S1981 Routine MSI-Analysis in Advanced Adenomas in Patients Younger Than 45 Years Leads to the Identification of More Patients at High Risk for Lynch Syndrome by Leenen, Celine H, van Lier, Margot G, Wagner, Anja, Dinjens, W, Dubbink, Erik-Jan, van Leerdam, Monique E, Kuipers, Ernst J, Steyerberg, Ewout W

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Treatment and Surveillance of Small Bowel Polyps Using Double Balloon Enteroscopy in Patients with Peutz-Jeghers Syndrome by Gao, Hong, Van Lier, Margot G, Poley, Jan-Werner, Kuipers, Ernst J, Van, M.E. Leerdam, Mensink, Peter

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