Search Results - "van Lier, Johan E."

Phthalocyanine–Peptide Conjugates: Receptor-Targeting Bifunctional Agents for Imaging and Photodynamic Therapy by Ranyuk, Elena, Cauchon, Nicole, Klarskov, Klaus, Guérin, Brigitte, van Lier, Johan E

“…The synthesis of a series of new zinc phthalocyanine–peptide conjugates targeting the gastrin-releasing peptide (GRP) and integrin receptors is reported. Two…”
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Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes by Amendoeira, Ana F, Luz, André, Valente, Ruben, Roma-Rodrigues, Catarina, Ali, Hasrat, van Lier, Johan E, Marques, Fernanda, Baptista, Pedro V, Fernandes, Alexandra R

“…Estradiol-BODIPY linked via an 8-carbon spacer chain and 19-nortestosterone- and testosterone-BODIPY linked via an ethynyl spacer group were evaluated for cell…”
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Cholesterol Hydroperoxides as Substrates for Cholesterol-Metabolizing Cytochrome P450 Enzymes and Alternative Sources of 25-Hydroxycholesterol and other Oxysterols by van Lier, Johan E., Mast, Natalia, Pikuleva, Irina A.

“…The interaction of the primary autoxidation products of cholesterol, namely 25‐ and 20ξ‐hydroperoxides, with the four principal cholesterol‐metabolizing…”
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Targeted photodynamic therapy via receptor mediated delivery systems by Sharman, Wesley M., van Lier, Johan E., Allen, Cynthia M.

“…Targeted photodynamic therapy (PDT) offers the opportunity of enhancing photodynamic efficiency by directly targeting diseased cells and tissues. While…”
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A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-[F-18]fluoro-D-glucose in murine models of breast cancer by Aliaga, Antonio, Rousseau, Jacques A, Cadorette, Jules, Croteau, Etienne, van Lier, Johan E, Lecomte, Roger, Bénard, François

“…We used small animal positron emission tomography (PET) imaging to monitor the time-course of tumor metabolic response to hormone and chemotherapy in a murine…”
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An efficient method for the synthesis of C–C connected phthalocyanine–porphyrin oligomers by Ali, Hasrat, Lier, Johan E. van

“…An efficient one-step method for the synthesis of covalently linked phthalocyanine–porphyrin (Pc–Por) hetero-dyads and Pc–Por–Pc hetero-triads, connected…”
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Phthalocyanine-Peptide Conjugates via Palladium-Catalyzed Cross-Coupling Reactions by Ali, Hasrat, Ait-Mohand, Samia, Gosselin, Simon, van Lier, Johan E, Guérin, Brigitte

“…Phthalocyanines (Pc) were conjugated with peptide moieties to improve their target selectivity for potential use as fluorescence and/or positron emission…”
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Phthalocyanine-boronates: a synthon for the preparation of molecular assemblies by Ali, Hasrat, Lier, Johan E. van

“…Covalently linked phthalocyanine–phthalocyanine (Pc–Pc) heterodimers and Pc–Pc triad phthalocyanines connected through phenyl–phenyl (C–C) linkages are…”
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X-ray structure analysis of the cholesterol 25- and 20-hydroperoxides, the elusive primary sidechain autoxidation products of cholesterol by Ali, Hasrat, van Lier, Johan E.

“…[Display omitted] •The X-ray structure analysis of the primary cholesterol sidechain autoxidation products, cholesterol 25- and 20-hydroperoxides, are…”
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New Therapeutic Targets for Brain Function and Disease by van Lier, Johan E

“…Cytochrome P450 46A1 (CYP46A1) or cholesterol-24-hydroxylase is responsible for cholesterol metabolism and homeostasis in the human brain. More recently its…”
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Structure−Photodynamic Activity Relationships of Substituted Zinc Trisulfophthalocyanines by Cauchon, Nicole, Tian, Hongjian, Langlois, Réjean, La Madeleine, Carole, Martin, Stephane, Ali, Hasrat, Hunting, Darel, van Lier, Johan E

“…To identify optimal features of metalated sulfophthalocyanine dyes for their use as photosensitizers in the photodynamic therapy of cancer, we synthesized a…”
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Predicting efficacy of photodynamic therapy by real-time FDG-PET in a mouse tumour model by Cauchon, Nicole, Turcotte, Eric, Lecomte, Roger, Hasséssian, Haroutioun M, Lier, Johan E van

“…Dynamic positron emission tomography (PET) combined with the constant infusion of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) as a tracer permits real-time…”
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Two-photon absorption cross section of excited phthalocyanines by a femtosecond Ti-sapphire laser by Mir, Youssef, van Lier, Johan E, Allard, Jean-François, Morris, Denis, Houde, Daniel

“…In the past few years, photodynamic therapy (PDT) has become a major treatment for neovascular age-related macular degeneration (AMD) in which there is…”
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Pd‐Catalyzed Sonogashira Cross‐Coupling Reactions of gem‐Dibromovinyl BODIPY Derivatives by Ali, Hasrat, Guérin, Brigitte, Lier, Johan E.

“…4,4‐Difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY) derivatives bearing gem‐dibromovinyl moieties at either the β‐ or α‐positions of the pyrrole rings,…”
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Oxygen Dependence of Two-photon Activation of Zinc and Copper Phthalocyanine Tetrasulfonate in Jurkat Cells by Mir, Youssef, Van Lier, Johan E., Paquette, Benoit, Houde, Daniel

“…Photodynamic therapy (PDT), the use of light‐activated drugs, is a promising treatment of cancer as well as several nonmalignant conditions. However, the…”
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Photodynamic Activity of Substituted Zinc Trisulfophthalocyanines: Role of Plasma Membrane Damage by Cauchon, Nicole, Nader, Moni, Bkaily, Ghassan, van Lier, Johan E., Hunting, Darel

“…We recently reported that variations in cellular phototoxicity among a series of alkynyl-substituted zinc trisulfophthalocyanines (ZnPcS3Cn) correlates with…”
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Synthesis and spectral properties of estrogen- and androgen-BODIPY conjugates by Osati, Samira, Ali, Hasrat, Guerin, Brigitte, van Lier, Johan E.

“…[Display omitted] •BODIPY and aza-BODIPY are attached to substituted estradiol, testosterone and 19-nortestoterone.•Pd-catalyzed Sonogashira and…”
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BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities by Osati, Samira, Ali, Hasrat, Marques, Fernanda, Paquette, Michel, Beaudoin, Simon, Guerin, Brigitte, Leyton, Jeffrey V., van Lier, Johan E.

“…[Display omitted] In vivo imaging of estrogen receptor (ER) densities in human breast cancer is a potential tool to stage disease, guide treatment protocols…”
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(68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine conjugates as fluorescent/PET bimodal imaging probes by Ranyuk, Elena, Lebel, Réjean, Bérubé-Lauzière, Yves, Klarskov, Klaus, Lecomte, Roger, van Lier, Johan E, Guérin, Brigitte

“…In this paper, we describe the synthesis and characterization of a series of new bimodal probes combining water-soluble sulfonated zinc phthalocyanine (ZnPc)…”
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Synthesis of phthalocyanine dimers, trimers, and oligomers bridged via phenyl groups by Ali, Hasrat, van Lier, Johan E.

“…Several phthalocyanine dimers, trimers, and oligomers bridged via aryl (phenyl) groups were prepared using the Suzuki–Miyaura cross coupling reaction of…”
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