Search Results - "van Leuven, F"

GSK3ß, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at Serine-9 by Dewachter, I, Ris, L, Jaworski, T, Seymour, C.M, Kremer, A, Borghgraef, P, De Vijver, H, Godaux, E, Van Leuven, F

“…Abstract Accumulating evidence implicates deregulation of GSK3ß as a converging pathological event in Alzheimer's disease and in neuropsychiatric disorders,…”
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Small cysteine-rich antifungal proteins from radish: their role in host defense by Terras, F.R.G. (Katholieke Universiteit Leuven, Heverlee, Belgium.), Eggermont, K, Kovaleva, V, Raikhel, N.V, Osborn, R.W, Kester, A, Rees, S.B, Torrekens, S, Leuven, F. van, Vanderleyden, J

“…Radish seeds have previously been shown to contain two homologous, 5-kD cysteine-rich proteins designated Raphanus sativus-antifungal protein 1 (Rs-AFP1) and…”
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Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin by Ochs, S M, Dorostkar, M M, Aramuni, G, Schön, C, Filser, S, Pöschl, J, Kremer, A, Van Leuven, F, Ovsepian, S V, Herms, J

“…Central nervous glycogen synthase kinase 3β (GSK3β) is implicated in a number of neuropsychiatric diseases, such as bipolar disorder, depression,…”
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Expression in brain of amyloid precursor protein mutated in the alpha‐secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice by Moechars, D., Lorent, K., De Strooper, B., Dewachter, I., Van Leuven, F.

“…A double mutation in the alpha‐secretase site in the betaA4 region of mouse amyloid precursor protein (APP) reduced its secretion from COS cells, polarized…”
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Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice by Van den Haute, C., Spittaels, K., Van Dorpe, J., Lasrado, R., Vandezande, K., Laenen, I., Geerts, H., Van Leuven, F.

“…The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated…”
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Alpha-2 Macroglobulin Controls Trophoblast Positioning in Mouse Implantation Sites by Esadeg, S, He, H, Pijnenborg, R, Van Leuven, F, Croy, B.A

“…In humans, functional deficiency of α-2M is not known, implying α2M is essential for gestational success. Mice, deficient in two members of the α-2…”
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Production of intracellular amyloid‐containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence by De Strooper, B., Simons, M., Multhaup, G., Van Leuven, F., Beyreuther, K., Dotti, C. G.

“…A distinguishing feature of Alzheimer's disease (AD) is the deposition of amyloid plaques in brain parenchyma. These plaques arise by the abnormal accumulation…”
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Increased Trypanosoma cruzi Invasion and Heart Fibrosis Associated with High Transforming Growth Factor β Levels in Mice Deficient in α2-Macroglobulin by WAGHABI, M. C, COUTINHO, C. M. L. M, SOEIRO, M. N. C, PEREIRA, M. C. S, FEIGE, J.-J, KERAMIDAS, M, COSSON, A, MINOPRIO, P, VAN LEUVEN, F, ARAUJO-JORGE, T. C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein by Lorent, K., Overbergh, L., Moechars, D., de Strooper, B., van Leuven, F., van den Berghe, H.

“…We have analysed by northern blotting and by in situ hybridization the expression patterns of eight different genes during the second half of mouse embryonic…”
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The beta‐amyloid domain is essential for axonal sorting of amyloid precursor protein by Tienari, P. J., De Strooper, B., Ikonen, E., Simons, M., Weidemann, A., Czech, C., Hartmann, T., Ida, N., Multhaup, G., Masters, C. L., Van Leuven, F., Beyreuther, K., Dotti, C. G.

“…We have analysed the axonal sorting signals of amyloid precursor protein (APP). Wild‐type and mutant versions of human APP were expressed in hippocampal…”
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Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice by Dewachter, I, Filipkowski, R.K, Priller, C, Ris, L, Neyton, J, Croes, S, Terwel, D, Gysemans, M, Devijver, H, Borghgraef, P, Godaux, E, Kaczmarek, L, Herms, J, Van Leuven, F

“…Abstract Evidence is accumulating for a role for amyloid peptides in impaired synaptic plasticity and cognition, while the underlying mechanisms remain…”
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Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease by Vanhoutte, G., Dewachter, I., Borghgraef, P., Van Leuven, F., Van der Linden, A.

“…Transgenic mice overexpressing the London mutant of human amyloid precursor protein (APP[V717I]) in neurons develop amyloid plaques in the brain, thus…”
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Impact of genetic defects on atherosclerosis in patients suspected of familial hypercholesterolaemia by Descamps, O. S., Gilbeau, J-P., Leysen, X., Van Leuven, F., Heller, F. R.

“…Among patients with severe hypercholesterolaemia and a family history of early cardiovascular disease, we assessed whether patients with mutations of…”
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Cloning, sequencing, and phenotypic analysis of laf1, encoding the flagellin of the lateral flagella of Azospirillum brasilense Sp7 by Moens, S, Michiels, K, Keijers, V, Van Leuven, F, Vanderleyden, J

“…Azospirillum brasilense can display a single polar flagellum and several lateral flagella. The A. brasilense Sp7 gene laf1, encoding the flagellin of the…”
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5‐HT 4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice by Cachard‐Chastel, M, Lezoualc'h, F, Dewachter, I, Deloménie, C, Croes, S, Devijver, H, Langlois, M, Van Leuven, F, Sicsic, S, Gardier, A M

“…Background and purpose: A strategy to treat Alzheimer's disease (AD) is to increase the soluble form of amyloid precursor protein (sAPPα), a promnesic protein,…”
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Coexpression of GSK-3β Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau by Nuydens, R., Van Den Kieboom, G., Nolten, C., Verhulst, C., Van Osta, P., Spittaels, K., Van den Haute, C., De Feyter, E., Geerts, H., Van Leuven, F.

“…Coexpression of constitutively active GSK-3β[S9A] rescued the axonal pathology induced by overexpression of human tau in transgenic mice (Spittaels et al.,…”
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Synthesis of F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [C]PIB by Serdons, K, Verduyckt, T, Vanderghinste, D, Cleynhens, J, Borghgraef, P, Vermaelen, P, Terwinghe, C, Van Leuven, F, Van Laere, K, Kung, H, Bormans, G, Verbruggen, A

“…2-(4'-[18F]fluorophenyl)-1,3-benzothiazole was synthesized as a fluorine-18 labelled derivative of the Pittsburg Compound-B (PIB), which has known affinity for…”
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5‐HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice by Cachard‐Chastel, M, Lezoualc'h, F, Dewachter, I, Deloménie, C, Croes, S, Devijver, H, Langlois, M, Leuven, F, Sicsic, S, Gardier, A M

“…Background and purpose: A strategy to treat Alzheimer's disease (AD) is to increase the soluble form of amyloid precursor protein (sAPPα), a promnesic protein,…”
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Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1 by Dewachter, I, Ris, L, Croes, S, Borghgraef, P, Devijver, H, Voets, T, Nilius, B, Godaux, E, Van Leuven, F

“…Abstract The function of presenilin1 (PS1) in intra-membrane proteolysis is undisputed, as is its role in neurodegeneration in FAD, in contrast to its exact…”
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Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice by Tesseur, Ina, Van Dorpe, Jo, Spittaels, Kurt, Van den Haute, Chris, Moechars, Dieder, Van Leuven, Fred

“…Epidemiological studies have established that the epsilon 4 allele of the ApoE gene ( ApoE4) constitutes an important risk factor for Alzheimer's disease and…”
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