Search Results - "van Lent, PL"

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis by Schelbergen, R F, Geven, E J, van den Bosch, M H J, Eriksson, H, Leanderson, T, Vogl, T, Roth, J, van de Loo, F A J, Koenders, M I, van der Kraan, P M, van den Berg, W B, Blom, A B, van Lent, P L E M

“…Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We…”
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Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis by Hofkens, W., Storm, G., van den Berg, W.B., van Lent, P.L.

“…Encapsulation of glucocorticoids into long-circulating liposomes provides targeting of these drugs to the inflamed synovium in experimental arthritis and…”
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FcγRI (CD64) Contributes Substantially to Severity of Arthritis, Hypersensitivity Responses, and Protection from Bacterial Infection by Ioan-Facsinay, A, de Kimpe, S.J, Hellwig, S.M.M, van Lent, P.L, Hofhuis, F.M.A, van Ojik, H.H, Sedlik, C, da Silveira, S.A, Gerber, J, de Jong, Y.F, Roozendaal, R, Aarden, L.A, van den Berg, W.B, Saito, T, Mosser, D, Amigorena, S, Izui, S, van Ommen, G-J.B, van Vugt, M, van de Winkel, J.G.J, Verbeek, J.S

“…The high-affinity receptor for IgG, FcγRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcγRIII and complement…”
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Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis by Mahler, EAM, Zweers, MC, van Lent, PL, Blom, AB, van den Hoogen, FH, van den Berg, WB, Roth, J, Vogl, T, Bijlsma, JWJ, van den Ende, CHM, den Broeder, AA

“…Objectives: To explore the association between S100A8/A9 serum levels with clinical and structural characteristics of patients with established knee, hip, or…”
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FcγRI Up-Regulation Induced by Local Adenoviral-Mediated Interferon-γ Production Aggravates Chondrocyte Death during Immune Complex-Mediated Arthritis by Nabbe, Karin C., van Lent, Peter L., Holthuysen, Astrid E., Kolls, Jay K., Verbeek, Sjef, van den Berg, Wim B.

“…Using various FcγR-deficient mice, we have obtained suggestive evidence that FcγRI on macrophages is responsible for severe cartilage destruction during…”
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Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA) by Blom, A B, van Lent, P L, van Vuuren, H, Holthuysen, A E, Jacobs, C, van de Putte, L B, van de Winkel, J G, van den Berg, W B

“…STATEMENT OF FINDINGS: We investigated the role of Fc gamma receptors (Fc gamma Rs) on synovial macrophages in immune-complex-mediated arthritis (ICA). ICA…”
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IL-13 overexpression during immune complex arthritis diminishes MMP-mediated VDIPEN expression by Nabbe, KC, van Lent, PL, Holthuysen, AE, Koch, AE, van den Berg, WB

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FcγRI up-regulation induced by local adenoviral-mediated IFN-γ production aggravates chondrocyte death during immune-complex-mediated arthritis by Nabbe, K, van Lent, PL, Holthuysen, AE, Sloetjes, AW, Kolls, J, Verbeek, JS, van den Berg, WB

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The inhibitory receptor FcγRII reduces joint inflammation in immune complex arthritis not only by inhibition of activatory FcγR but also by efficient clearance of immune complexes by van Lent, PL, Nabbe, K, Blom, AB, Holthuysen, AE, Verbeek, S, van den Berg, WB

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Role of interleukin 1 in antigen-induced exacerbations of murine arthritis by van de Loo, AA, Arntz, OJ, Bakker, AC, van Lent, PL, Jacobs, MJ, van den Berg, WB

“…The mechanism underlying the chronic and intermittent course of rheumatoid arthritis is not elucidated. In the present study, the role of interleukin 1 (IL-1)…”
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Fc[gamma]RI (CD64) Contributes Substantially to Severity of Arthritis, Hypersensitivity Responses, and Protection from Bacterial Infection by Ioan-Facsinay, A, de Kimpe, SJ, Hellwig, SMM, van Lent, PL, Hofhuis, FMA, van Ojik, HH, Sedlik, C, da Silveira, SA, Gerber, J, de Jong, YF, Roozendaal, R, Aarden, LA, van den Berg, WB, Saito, T, Mosser, D, Amigorena, S, Izui, S, van Ommen, G-JB, van Vugt, M, van de Winkel, JGJ, Verbeek, JS

“…The high-affinity receptor for IgG, FcγRI, shares its capacity to bind IgG2a immune complexes (IgG2a-IC) with the low-affinity receptor FcγRIII and complement…”
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In vivo role of phagocytic synovial lining cells in onset of experimental arthritis by Van Lent, PL, Van den Hoek, AE, Van den Bersselaar, LA, Spanjaards, MF, Van Rooijen, N, Dijkstra, CD, Van de Putte, LB, Van den Berg, WB

“…The in vivo role of phagocytic synovial lining cells (SLC) was studied in acute experimental arthritis in the mouse. SLCs were selectively depleted by…”
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Long-circulating liposomes for i.v. targeted delivery of glucocorticoids in arthritis by Metselaar, Josbert M, Wauben, Marca H M, Boerman, Otto C, Van Lent, Peter L, Storm, Gert

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Cationic immune complex arthritis in mice--a new model. Synergistic effect of complement and interleukin-1 by van Lent, PL, van den Bersselaar, LA, van den Hoek, AE, van de Loo, AA, van den Berg, WB

“…A novel cationic immune-complex-mediated arthritis (ICA) model was developed in mice. The highly cationic protein lysozyme was coupled to poly-L-lysine (PLL)…”
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Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leukocytes to articular cartilage by van Lent, PL, van den Bersselaar, L, van de Putte, LB, van den Berg, WB

“…The early and late effects of short-term immobilization on arthritic joints have been studied. Knee joints of mice in which an antigen-induced unilateral…”
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