Search Results - "van Leeuwen, Johannes P.T.M."

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia by Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J., Adisty, Maria N., Van Strien, Paulina M.H., van der Leije, Cindy S., Westers, Theresia M., Cremers, Eline M.P., Milanese, Chiara, Mastroberardino, Pier G., van Leeuwen, Johannes P.T.M., van der Eerden, Bram C.J., Touw, Ivo P., Kuijpers, Taco W., Kanaar, Roland, van de Loosdrecht, Arjan A., Vogl, Thomas, Raaijmakers, Marc H.G.P.

“…Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and…”
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Pro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells by Doorn, Joyce, van de Peppel, Jeroen, van Leeuwen, Johannes P.T.M, Groen, Nathalie, van Blitterswijk, Clemens A, de Boer, Jan

“…Abstract Human mesenchymal stromal cells (hMSCs) are able to differentiate into a wide variety of cell types, which makes them an interesting source for tissue…”
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Relation of Alleles of the Collagen Type Iα1 Gene to Bone Density and the Risk of Osteoporotic Fractures in Postmenopausal Women by Uitterlinden, André G, Burger, Huibert, Huang, Qiuju, Yue, Fang, McGuigan, Fiona E.A, Grant, Struan F.A, Hofman, Albert, van Leeuwen, Johannes P.T.M, Pols, Huibert A.P, Ralston, Stuart H

“…Osteoporosis is a common disorder characterized by reduced bone mineral density, deterioration of the microarchitecture of bone tissue, and increased risk of…”
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Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells by Bruedigam, Claudia, Eijken, Marco, Koedam, Marijke, Chiba, Hideki, van Leeuwen, Johannes P.T.M

“…Abstract Arteriosclerotic vascular disease is a major cardiac health problem in westernized countries and the primary cause of mortality in diabetic patients…”
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A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells by Barradas, Ana M.C, Fernandes, Hugo A.M, Groen, Nathalie, Chai, Yoke Chin, Schrooten, Jan, van de Peppel, Jeroen, van Leeuwen, Johannes P.T.M, van Blitterswijk, Clemens A, de Boer, Jan

“…Abstract The response of osteoprogenitors to calcium (Ca2+ ) is of primary interest for both normal bone homeostasis and the clinical field of bone…”
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Preliminary validation of assays to measure parameters of calcium metabolism in captive Asian and African elephants in western Europe by Sonsbeek, Gerda R. van, Kolk, Johannes H. van der, Leeuwen, Johannes P.T.M. van, Schaftenaar, Willem

“…Hypocalcemia is a well known cause of dystocia in animals, including elephants in captivity. In order to study calcium metabolism in elephants, it is of utmost…”
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Genetics and biology of vitamin D receptor polymorphisms by Uitterlinden, André G., Fang, Yue, van Meurs, Joyce B.J., Pols, Huibert A.P., van Leeuwen, Johannes P.T.M.

“…The vitamin D endocrine system is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and…”
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Decreased oxygen tension lowers reactive oxygen species and apoptosis and inhibits osteoblast matrix mineralization through changes in early osteoblast differentiation by Nicolaije, Claudia, Koedam, Marijke, van Leeuwen, Johannes P.T.M.

“…Accumulating data show that oxygen tension can have an important effect on cell function and fate. We used the human pre‐osteoblastic cell line SV‐HFO, which…”
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Activin A Suppresses Osteoblast Mineralization Capacity by Altering Extracellular Matrix (ECM) Composition and Impairing Matrix Vesicle (MV) Production by Alves, Rodrigo D.A.M., Eijken, Marco, Bezstarosti, Karel, Demmers, Jeroen A.A., van Leeuwen, Johannes P.T.M.

“…During bone formation, osteoblasts deposit an extracellular matrix (ECM) that is mineralized via a process involving production and secretion of highly…”
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Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map by Zhang, Shuang, Lyons, Nicholas, Koedam, Marijke, van de Peppel, Jeroen, van Leeuwen, Johannes P T M, van der Eerden, Bram C J

“…Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone…”
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Zika virus infection perturbs osteoblast function by Mumtaz, Noreen, Koedam, Marijke, van den Doel, Petra B., van Leeuwen, Johannes P. T. M., Koopmans, Marion P. G., van der Eerden, Bram C. J., Rockx, Barry

“…Zika virus (ZIKV) infection is typically characterized by a mild self-limiting disease presenting with fever, rash, myalgia and arthralgia and severe fetal…”
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Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling by Ratsma, Danielle M.A., Muller, Max, Koedam, Marijke, van Leeuwen, Johannes P.T.M., Zillikens, M. Carola, van der Eerden, Bram C.J.

“…One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic…”
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Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5 by Hoenderop, Joost G J, van Leeuwen, Johannes P T M, van der Eerden, Bram C J, Kersten, Ferry F J, van der Kemp, Annemiete W C M, Mérillat, Anne-Marie, Waarsing, Jan H, Rossier, Bernard C, Vallon, Volker, Hummler, Edith, Bindels, René J M

“…Ca2+ ions play a fundamental role in many cellular processes, and the extracellular concentration of Ca2+ is kept under strict control to allow the proper…”
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Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation by Dashti, Parisa, Lewallen, Eric A., Gordon, Jonathan A.R., Montecino, Martin A., van Leeuwen, Johannes P.T.M., Stein, Gary S., van der Eerden, Bram C.J., Davie, James R., van Wijnen, Andre J.

“…Osteogenic differentiation of mesenchymal cells is controlled by epigenetic enzymes that regulate post-translational modifications of histones. Compared to…”
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activin A-follistatin system: potent regulator of human extracellular matrix mineralization by Eijken, Marco, Swagemakers, Sigrid, Koedam, Marijke, Steenbergen, Cobie, Derkx, Pieter, Uitterlinden, André G, van der Spek, Peter J, Visser, Jenny A, de Jong, Frank H, Pols, Huibert A.P, van Leeuwen, Johannes P.T.M

“…Bone quality is an important determinant of osteoporosis, and proper osteoblast differentiation plays an important role in the control and maintenance of bone…”
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Oxygen-induced transcriptional dynamics in human osteoblasts are most prominent at the onset of mineralization by Nicolaije, Claudia, van de Peppel, Jeroen, van Leeuwen, Johannes P.T.M.

“…Oxygen tension plays an important role in the regulation of cellular processes. During hematopoietic stem cell (HSC) differentiation, HSCs migrate from one…”
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Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio by Tudpor, Kukiat, van der Eerden, Bram C.J, Jongwattanapisan, Prapaporn, Roelofs, Joris J.T.H, van Leeuwen, Johannes P.T.M, Bindels, René J.M, Hoenderop, Joost G.J

“…Abstract Thrombin and its receptor (TR) are, respectively, expressed in osteoclasts and osteoblasts. However, their physiological roles on bone metabolism have…”
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Sorting living mesenchymal stem cells using a TWIST1 RNA-based probe depends on incubation time and uptake capacity by Voskamp, Chantal, van de Peppel, Jeroen, Gasparini, Simona, Giannoni, Paolo, van Leeuwen, Johannes P. T. M., van Osch, Gerjo J. V. M., Narcisi, Roberto

“…Bone marrow derived mesenchymal stromal cells (BMSCs) are multipotent progenitors of particular interest for cell-based tissue engineering therapies. However,…”
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Tensin-3 oppositely regulates bone mesenchymal stromal cell-derived osteogenesis and adipogenesis by Zhang, Shuang, Koedam, Marijke, van de Peppel, Jeroen, van Leeuwen, Johannes P.T.M., van der Eerden, Bram

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A small molecule approach to engineering vascularized tissue by Doorn, Joyce, Fernandes, Hugo A.M, Le, Bach Q, van de Peppel, Jeroen, van Leeuwen, Johannes P.T.M, De Vries, Margreet R, Aref, Zeen, Quax, Paul H.A, Myklebost, Ola, Saris, Daniel B.F, van Blitterswijk, Clemens A, de Boer, Jan

“…Abstract The repertoire of growth factors determines the biological engagement of human mesenchymal stromal cells (hMSCs) in processes such as immunomodulation…”
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