Search Results - "van Leeuwen, Inge"
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Increased Risk of Cancer Other Than Melanoma in CDKN2A Founder Mutation (p16-Leiden)-Positive Melanoma Families
Published in Clinical cancer research (01-11-2008)“…Purpose: We report the largest study to date analyzing the risk of cancers other than melanoma in melanoma families positive for the same CDKN2A mutation…”
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Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis
Published in Human mutation (1997)“…Germline mutations of the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant predisposition…”
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Characterization of Familial Non-BRCA1/2 Breast Tumors by Loss of Heterozygosity and Immunophenotyping
Published in Clinical cancer research (15-03-2006)“…Purpose: Since the identification of BRCA1 and BRCA2 , there has been no major breast cancer susceptibility gene discovered by linkage analysis in breast…”
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Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5;10)(q22;q25) responsible for familial adenomatous polyposis in a Dutch pedigree
Published in Genes chromosomes & cancer (01-07-1995)“…Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer caused by germline mutations in the adenomatous polyposis coli (APC)…”
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Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families
Published in European journal of human genetics : EJHG (01-09-2008)“…In most Dutch melanoma families, a founder deletion in the melanoma susceptibility gene CDKN2A (which encodes p16) is present. This founder deletion…”
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Hereditary cancer registries improve the care of patients with a genetic predisposition to cancer: contributions from the Dutch Lynch syndrome registry
Published in Familial cancer (01-07-2016)“…The Dutch Hereditary Cancer Registry was established in 1985 with the support of the Ministry of Health (VWS). The aims of the registry are: (1) to promote the…”
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Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families
Published in European journal of human genetics : EJHG (01-08-2008)Get full text
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Erratum: Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families
Published in European journal of human genetics : EJHG (24-07-2008)Get full text
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Mutant BRCA1 alleles transmission: Different approaches and different biases
Published in International journal of cancer (01-01-2005)“…Recently, a non‐random transmission of BRCA1 mutant alleles to the off‐spring of carriers has been suggested. If confirmed by further studies, the finding will…”
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Clinical Findings with Implications for Genetic Testing in Families with Clustering of Colorectal Cancer
Published in The New England journal of medicine (20-08-1998)“…The lifetime risk of colorectal cancer among whites in the Western world is approximately 4 percent. The cause of colorectal cancer is multifactorial,…”
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Hereditary Nonpolyposis Colorectal Cancer Families Not Complying with the Amsterdam Criteria Show Extremely Low Frequency of Mismatch-Repair-Gene Mutations
Published in American journal of human genetics (01-08-1997)“…Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant cancer-susceptibility condition characterized by early onset colorectal…”
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Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16
Published in American journal of human genetics (01-02-1996)“…Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant cancer susceptibility condition. Inherited mutations in at least four DNA…”
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Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis
Published in American journal of human genetics (01-05-1995)“…Hereditary nonpolyposis colorectal cancer (HNPCC) is a relatively common autosomal dominant cancer-susceptibility condition. The recent isolation of the DNA…”
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Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis
Published in Genomics (San Diego, Calif.) (01-08-1992)“…Familial adenomatous polyposis (FAP) is a dominantly inherited condition predisposing to colorectal cancer. The recent isolation of the responsible gene…”
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Presymptomatic, prenatal, and exclusion testing for Huntington disease using seven closely linked DNA markers
Published in American journal of medical genetics (01-05-1991)“…Presymptomatic, testing, prenatal diagnosis, or exclusion testing are now available for persons at risk for Huntington disease. These tests will reduce…”
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Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis
Published in American journal of medical genetics (15-07-1992)“…Turcot syndrome (TS) is a rare genetic disease in which brain tumors occur in association with colonic polyposis. Since Turcot's original description in 1959,…”
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