Search Results - "van Leeuwen, Ester MM"

A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency by Volpi, Stefano, Cicalese, Maria Pia, Tuijnenburg, Paul, Tool, Anton T.J., Cuadrado, Eloy, Abu-Halaweh, Marwan, Ahanchian, Hamid, Alzyoud, Raed, Akdemir, Zeynep Coban, Barzaghi, Federica, Blank, Alexander, Boisson, Bertrand, Bottino, Cristina, Brigida, Immacolata, Caorsi, Roberta, Casanova, Jean-Laurent, Chiesa, Sabrina, Chinn, Ivan Kingyue, Dückers, Gregor, Enders, Anselm, Erichsen, Hans Christian, Forbes, Lisa R., Gambin, Tomasz, Gattorno, Marco, Karimiani, Ehsan Ghayoor, Giliani, Silvia, Gold, Michael S., Jacobsen, Eva-Maria, Jansen, Machiel H., King, Jovanka R., Laxer, Ronald M., Lupski, James R., Mace, Emily, Marcenaro, Stefania, Maroofian, Reza, Meijer, Alexander B., Niehues, Tim, Notarangelo, Luigi D., Orange, Jordan, Pannicke, Ulrich, Pearson, Chris, Picco, Paolo, Quinn, Patrick J., Schulz, Ansgar, Seeborg, Filiz, Stray-Pedersen, Asbjørg, Tawamie, Hasan, van Leeuwen, Ester M.M., Aiuti, Alessandro, Yeung, Rae, Schwarz, Klaus, Kuijpers, Taco W.

“…To the Editor: Recently, a novel syndrome of combined immunodeficiency, allergy, and “auto”inflammation caused by mutations in the ARPC1B gene has been…”
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High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells by Tuijnenburg, Paul, aan de Kerk, Daan J., Jansen, Machiel H., Morris, Ben, Lieftink, Cor, Beijersbergen, Roderick L., Leeuwen, Ester M.M., Kuijpers, Taco W.

“…Antibody production by the B cell compartment is a crucial part of the adaptive immune response. Dysregulated antibody production in the form of autoantibodies…”
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Generation and maintenance of memory CD4+ T Cells by van Leeuwen, Ester MM, Sprent, Jonathan, Surh, Charles D

“…In the course of an immune response to an infectious microbe, pathogen-specific naïve CD4+ T cells proliferate extensively and differentiate into effector…”
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Does COVID-19 impact the prevalence of myositis specific antibodies in the Netherlands? A comparative nationwide study by Kamperman, Renske G, van Leeuwen, Ester MM, Willems, Myrthe, van der Kooi, Anneke J, Gelderman, Kyra A, Hamann, Dörte, van Lochem, Ellen G, Meek, Bob, van der Molen, Renate G, Platteel, Anouk CM, Otten, Henny G, Schreurs, Marco WJ, Raaphorst, Joost

“…•Study with nationwide data on MSAs (n=4962 samples) from a pre-COVID-19 year and a year within the pandemic.•Three MSAs (PL7, SRP and MDA5) are more prevalent…”
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Long-term pneumococcal vaccine immunogenicity following allogeneic hematopoietic stem cell transplantation by Langedijk, Annefleur C., van Aalst, Mariëlle, Meek, Bob, van Leeuwen, Ester M.M., Zeerleder, Sacha, Meijer, Ellen, Hazenberg, Mette D., Grobusch, Martin P., Goorhuis, Abraham

“…•We recommend a new pneumococcal vaccination scheme after allo-HSCT.•This scheme combines the benefits of early (≤6 months) and late (>1 year)…”
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Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia by Beurskens, Charlotte J, Horn, Janneke, de Boer, Anita M Tuip, Schultz, Marcus J, van Leeuwen, Ester Mm, Vroom, Margreeth B, Juffermans, Nicole P

“…Induced hypothermia is increasingly applied as a therapeutic intervention in ICUs. One of the underlying mechanisms of the beneficial effects of hypothermia is…”
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B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses by Verhoeven, Dorit, Grinwis, Lucas, Marsman, Casper, Jansen, Machiel H, Van Leeuwen, Ester Mm, Kuijpers, Taco W

“…B cell-targeted therapies, such as CD20-targeting mAbs, deplete B cells but do not target the autoantibody-producing plasma cells (PCs). PC-targeting therapies…”
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Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling by Alves, Nuno L, van Leeuwen, Ester M M, Derks, Ingrid A M, van Lier, René A W

“…IL-7Ralpha is essential for the development and homeostatic maintenance of mature T cells. Studies in humans and mice have shown that IL-7Ralpha expression is…”
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Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function by Remmerswaal, Ester B M, Klarenbeek, Paul L, Alves, Nuno L, Doorenspleet, Marieke E, van Schaik, Barbera D C, Esveldt, Rebecca E E, Idu, Mirza M, van Leeuwen, Ester M M, van der Bom-Baylon, Nelly, van Kampen, Antoine H C, Koch, Sven D, Pircher, Hanspeter, Bemelman, Frederike J, Ten Brinke, Anja, Baas, Frank, Ten Berge, Ineke J M, van Lier, Rene A W, de Vries, Niek

“…Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice,…”
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Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model by De Jong, Hanna K, Achouiti, Ahmed, Koh, Gavin C K W, Parry, Christopher M, Baker, Stephen, Faiz, Mohammed Abul, van Dissel, Jaap T, Vollaard, Albert M, van Leeuwen, Ester M M, Roelofs, Joris J T H, de Vos, Alex F, Roth, Johannes, van der Poll, Tom, Vogl, Thomas, Wiersinga, Willem Joost

“…Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide…”
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Hyposplenism: Comparison of different methods for determining splenic function by Lammers, A.J. Jolanda, de Porto, Alexander P.N.A., Bennink, Roelof J., van Leeuwen, Ester M.M., Biemond, Bart J., Goslings, J. Carel, van Marle, Jan, ten Berge, Ineke J.M., Speelman, Peter, Hoekstra, Joost B.L.

“…Asplenic patients are at risk for pneumococcal sepsis. Patients with hyposplenic function, such as associated with sickle cell disease (SCD), are also at risk…”
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Identification of B cell defects using age-defined reference ranges for in vivo and in vitro B cell differentiation by aan de Kerk, Daan J, Jansen, Machiel H, ten Berge, Ineke J M, van Leeuwen, Ester M M, Kuijpers, Taco W

“…Primary immunodeficiencies consist to a large extent of B cell defects, as indicated by inadequate Ab levels or response upon immunization. Many B cell defects…”
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Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis by aan de Kerk, Daan J, van Leeuwen, Ester M.M, Jansen, Machiel H, van den Berg, J. Merlijn, Alders, Marielle, Vermont, Clementine L, van Lier, René A.W, Pals, Steven T, Kuijpers, Taco W

“…Abstract Mutations in the DOCK8 gene define the most common form of autosomal-recessive Hyper-IgE-syndrome (AR-HIES/OMIM#243700). In a patient with extensive…”
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The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines by Gamadia, Laila E, van Leeuwen, Ester M. M, Remmerswaal, Ester B. M, Yong, Si-La, Surachno, Sugianto, Wertheim-van Dillen, Pauline M. E, ten Berge, Ineke J. M, van Lier, Rene A. W

“…Based on the expression of the TNFR SFP CD27, two Ag-primed CD8(+) T cell subsets can be discerned in the circulation of healthy individuals: CD27(+) T cells…”
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A New Subset of Human Naive CD8 super(+) T Cells Defined by Low Expression of IL-7R alpha by Alves, Nuno L, van Leeuwen, Ester MM, Remmerswaal, Ester BM, Vrisekoop, Nienke, Tesselaar, Kiki, Roosnek, Eddy, ten Berge, Ineke JM, van Lier, Rene AW

“…Concomitant with an increased number of memory-type cells, the amount of naive T cells steadily declines with age. Although the regulatory mechanisms behind…”
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Human virus-specific CD8 super(+) T cells: diversity specialists by van Leeuwen, Ester MM, de Bree, Godelieve J, ten Berge, Ineke JM, van Lier, Rene AW

“…Human viruses elicit functionally highly diverse CD8 super(+) T-cell responses. This variation, which manifests in the memory or latency stage, includes…”
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Selective accumulation of differentiated CD8 super(+) T cells specific for respiratory viruses in the human lung by de Bree, Godelieve J, van Leeuwen, Ester MM, Out, Theo A, Jansen, Henk M, Jonkers, Rene E, van Lier, Rene AW

“…The lungs are frequently challenged by viruses, and resident CD8 super(+) T cells likely contribute to the surveillance of these pathogens. To obtain insight…”
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Differential Usage of Cellular Niches by Cytomegalovirus versus EBV- and Influenza Virus-Specific CD8 super(+) T Cells by van Leeuwen, Ester MM, Koning, Jasper J, Remmerswaal, Ester BM, van Baarle, Debbie, van Lier, Rene AW, ten Berge, Ineke JM

“…Immunological memory provides long-term protection against reinfection or reactivation of pathogens. Murine memory T cell populations may be compressed…”
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Emergence of a CD4 super(+)CD28 super(-) Granzyme B super(+), Cytomegalovirus-Specific T Cell Subset after Recovery of Primary Cytomegalovirus Infection by Van Leeuwen, Ester MM, Remmerswaal, Ester BM, Vossen, Mireille TM, Rowshani, Ajda T, Wertheim-Van Dillen, Pauline ME, Van Lier, Rene AW, Ten Berge, Ineke JM

“…Cytotoxic CD4 super(+)CD28 super(-) T cells form a rare subset in human peripheral blood. The presence of CD4 super(+)CD28 super(-) cells has been associated…”
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Functional re-expression of CCR7 on CMV-specific CD8 super(+) T cells upon antigenic stimulation by van Leeuwen, Ester MM, van Buul, Jaap D, Remmerswaal, Ester BM, Hordijk, Peter L, ten Berge, Ineke JM, van Lier, Rene AW

“…During latency circulating human cytomegalovirus (CMV)-specific CD8 super(+) T cells do not express the chemokine receptor CCR7. We here show that…”
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