Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function

Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase i...

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Bibliographic Details
Published in:	Frontiers in cell and developmental biology Vol. 8; p. 619079
Main Authors:	Pham, Tan Phát, Bink, Diewertje I, Stanicek, Laura, van Bergen, Anke, van Leeuwen, Esmee, Tran, Yvonne, Matic, Ljubica, Hedin, Ulf, Wittig, Ilka, Dimmeler, Stefanie, Boon, Reinier A
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 11-01-2021
Subjects:	aging cardiovascular disease Cell and Developmental Biology DNA damage endothelial cell LncRNA – long non-coding RNA Medicin och hälsovetenskap cardiovascular disease aging LncRNA – long non-coding RNA DNA damage endothelial cell
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Summary:	Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase in DNA damage is one of the hallmarks of aging and can be repaired by the DNA signaling and repair system. In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. This study identifies Aerrie as a novel factor in genomic stability and as a binding partner of YBX1 in responding to DNA damage.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Maarten M. G. van den Hoogenhof, Heidelberg University Hospital, Germany Reviewed by: Kewal Asosingh, Cleveland Clinic, United States; Leon J. De Windt, Maastricht University, Netherlands This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:	2296-634X 2296-634X
DOI:	10.3389/fcell.2020.619079