Search Results - "van Laar, T."

Deswelling and deformation of microgels in concentrated packings by Bouhid de Aguiar, I., van de Laar, T., Meireles, M., Bouchoux, A., Sprakel, J., Schroën, K.

“…Increasing the particle density of a suspension of microgel colloids above the point of random-close packing, must involve deformations of the particle to…”
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A Method for Automatic and Objective Scoring of Bradykinesia Using Orientation Sensors and Classification Algorithms by Martinez-Manzanera, O., Roosma, E., Beudel, M., Borgemeester, R. W. K., van Laar, T., Maurits, N. M.

“…Correct assessment of bradykinesia is a key element in the diagnosis and monitoring of Parkinson's disease. Its evaluation is based on a careful assessment of…”
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Transition-state theory predicts clogging at the microscale by Laar, T. van de, Klooster, S. ten, Schroën, K., Sprakel, J.

“…Clogging is one of the main failure mechanisms encountered in industrial processes such as membrane filtration. Our understanding of the factors that govern…”
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Study protocol of the GRoningen early-PD Ambroxol treatment (GREAT) trial: a randomized, double-blind, placebo-controlled, single center trial with ambroxol in Parkinson patients with a GBA mutation by Siemeling, O, Slingerland, S, van der Zee, S, van Laar, T

“…To date, no disease modifying therapies are available for Parkinson's disease (PD). Since PD is the second most prevalent neurodegenerative disorder, there is…”
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The Personalized Parkinson Project: examining disease progression through broad biomarkers in early Parkinson's disease by Bloem, B R, Marks, Jr, W J, Silva de Lima, A L, Kuijf, M L, van Laar, T, Jacobs, B P F, Verbeek, M M, Helmich, R C, van de Warrenburg, B P, Evers, L J W, intHout, J, van de Zande, T, Snyder, T M, Kapur, R, Meinders, M J

“…Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression of Parkinson's disease has stagnated. Consequently, patients do not…”
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Gonadotrophins or clomiphene citrate in women with normogonadotropic anovulation and CC failure: does the endometrium matter? by Bordewijk, E M, Weiss, N S, Nahuis, M J, Kwee, J, Lambeek, A F, van Unnik, G A, Vrouenraets, F P J, Cohlen, B J, van de Laar-van Asseldonk, T A M, Lambalk, C B, Goddijn, M, Hompes, P G, van der Veen, F, Mol, B W J, van Wely, M

“…Abstract STUDY QUESTION Is endometrial thickness (EMT) a biomarker to select between women who should switch to gonadotropins and those who could continue…”
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Gonadotrophins versus clomiphene citrate with or without IUI in women with normogonadotropic anovulation and clomiphene failure: a cost-effectiveness analysis by Bordewijk, E M, Weiss, N S, Nahuis, M J, Bayram, N, van Hooff, M H A, Boks, D E S, Perquin, D A M, Janssen, C A H, van Golde, R J T, Lambalk, C B, Goddijn, M, Hompes, P G, van der Veen, F, Mol, B W J, van Wely, M

“…Abstract STUDY QUESTION Are six cycles of ovulation induction with gonadotrophins more cost-effective than six cycles of ovulation induction with clomiphene…”
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Comparison of the Performance of the PanBio COVID-19 Antigen Test in SARS-CoV-2 B.1.1.7 (Alpha) Variants versus non-B.1.1.7 Variants by van Ogtrop, M L, van de Laar, T J W, Eggink, D, Vanhommerig, J W, van der Reijden, W A

“…This study evaluates the performance of the PanBio COVID-19 antigen (Ag) test as part of a hospital infection control policy. Hospital staff was encouraged to…”
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Lower Incidence of Parvovirus-B19 Infections in Dutch Blood Donors during SARS-CoV-2 Pandemic by Molenaar-de Backer, M W, Hogema, B M, Koppelman, M H, van de Laar, T J, Slot, E, Zaaijer, H L

“…During the SARS-CoV-2 pandemic, several studies reported a lower incidence of respiratory infections other than COVID-19 compared to previous years, but bias…”
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From cooperative to uncorrelated clogging in cross-flow microfluidic membranes by van Zwieten, R., van de Laar, T., Sprakel, J., Schroën, K.

“…The operational lifetime of filtration membranes is reduced by the clogging of pores and subsequent build-up of a fouling or cake layer. Designing membrane…”
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The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α by Gort, E H, van Haaften, G, Verlaan, I, Groot, A J, Plasterk, R H A, Shvarts, A, Suijkerbuijk, K P M, van Laar, T, van der Wall, E, Raman, V, van Diest, P J, Tijsterman, M, Vooijs, M

“…Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that play a crucial role in oxygen homeostasis. Intratumoral hypoxia and genetic…”
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Radiation of parotid or submandibular glands is effective for drooling in patients with parkinsonism; a randomised double-blind placebo-controlled trial by Steenbakkers, R.J.H.M., van Doornik, S.P., Vissink, A., Kerdijk, W., van Laar, T.

“…Drooling is a common symptom in patients with parkinsonism, causing physical and emotional distress. It is unknown which major salivary glands are the best…”
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Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer by Suijkerbuijk, K.P.M., Fackler, M.J., Sukumar, S., van Gils, C.H., van Laar, T., van der Wall, E., Vooijs, M., van Diest, P.J.

“…Promoter methylation is a common epigenetic mechanism to silence tumor suppressor genes during breast cancer development. We investigated whether…”
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Case study of the diurnal variability of chemically active species with respect to boundary layer dynamics during DOMINO by van Stratum, B. J. H, Vilà-Guerau de Arellano, J, Ouwersloot, H. G, van den Dries, K, van Laar, T. W, Martinez, M, Lelieveld, J, Diesch, J.-M, Drewnick, F, Fischer, H, Hosaynali Beygi, Z, Harder, H, Regelin, E, Sinha, V, Adame, J. A, Sörgel, M, Sander, R, Bozem, H, Song, W, Williams, J, Yassaa, N

“…We study the interactions between atmospheric boundary layer (ABL) dynamics and atmospheric chemistry using a mixed-layer model coupled to chemical reaction…”
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Discontinuous nature of the repulsive-to-attractive colloidal glass transition by van de Laar, T., Higler, R., Schroën, K., Sprakel, J.

“…In purely repulsive colloidal systems a glass transition can be reached by increasing the particle volume fraction beyond a certain threshold. The resulting…”
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From highly specialised to generally available modelling of shear induced particle migration for flow segregation based separation technology by Drijer, I., van de Laar, T., Vollebregt, H.M., Schroën, C.G.P.H.

“…•Commercial CFD software (STAR-CCM+) is used to describe particle migration in flow.•Shear induced diffusion (SID) can be described by this accessible…”
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Protocol of a randomised delayed-start double-blind placebo-controlled multi-centre trial for Levodopa in EArly Parkinson's disease: the LEAP-study by Verschuur, Constant V M, Suwijn, S R, Post, B, Dijkgraaf, M, Bloem, B R, van Hilten, J J, van Laar, T, Tissingh, G, Deuschl, G, Lang, A E, de Haan, R J, de Bie, R M A

“…The aim of this study is to investigate if early treatment with levodopa has a beneficial disease modifying effect on Parkinson's disease (PD) symptoms and…”
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Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries by Hamers, F P, Lankhorst, A J, van Laar, T J, Veldhuis, W B, Gispen, W H

“…Analysis of locomotion is an important tool in the study of peripheral and central nervous system damage. Most locomotor scoring systems in rodents are based…”
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Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease by Verschuur, Constant V.M, Suwijn, Sven R, Boel, Judith A, Post, Bart, Bloem, Bas R, van Hilten, Johannes J, van Laar, Teus, Tissingh, Gerrit, Munts, Alexander G, Deuschl, Guenther, Lang, Anthony E, Dijkgraaf, Marcel G.W, de Haan, Rob J, de Bie, Rob M.A

“…In a randomized, delayed-start trial of levodopa in Parkinson’s disease, with one group receiving the drug for 80 weeks and the other starting at 40 weeks, the…”
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Hypoxia-inducible factor-1α expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas by GORT, E. H, GROOT, A. J, DERKS VAN DE VEN, T. L. P, VAN DER GROEP, P, VERLAAN, I, VAN LAAR, T, VAN DIEST, P. J, VAN DER WALL, E, SHVARTS, A

“…Hypoxia-inducible factor-1 alpha (HIF-1α) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response to…”
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