Search Results - "van Laar, Jacob M."

Mycophenolate mofetil, azathioprine and tacrolimus: mechanisms in rheumatology by Broen, Jasper C. A., van Laar, Jacob M.

“…The introduction of biologic DMARDs into rheumatology has resulted in a substantial reduction of the burden of many rheumatic diseases. In the slipstream of…”
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Editorial: Stem cell transplantation in autoimmune diseases (AID) by Schmalzing, Marc, Henes, Joerg, van Laar, Jacob M, Sullivan, Keith M

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Severe thrombotic microangiopathy after autologous stem cell transplantation in systemic sclerosis: a case report by Sharif, Maryam O., Leavis, Helen L., van Paassen, Pieter, van Rhenen, Anna, Timmermans, Sjoerd A. M. E. G., Ton, Evelien, Laar, Jacob M. van, Spierings, Julia

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Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies by Pouw, Juliëtte N., Olde Nordkamp, Michel A. M., van Kempen, Tessa, Concepcion, Arno N., van Laar, Jacob M., van Wijk, Femke, Spierings, Julia, Leijten, Emmerik F. A., Boes, Marianne

“…In psoriatic arthritis (PsA), predisposing class I HLA alleles, the presence of synovial clonally proliferated CD8 + T cells and autoantibodies all point…”
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Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial by Khanna, Dinesh, Prof, Denton, Christopher P, Prof, Jahreis, Angelika, MD, van Laar, Jacob M, Prof, Frech, Tracy M, MD, Anderson, Marina E, FRCP, Baron, Murray, MD, Chung, Lorinda, MD, Fierlbeck, Gerhard, MD, Lakshminarayanan, Santhanam, MD, Allanore, Yannick, Prof, Pope, Janet E, MD, Riemekasten, Gabriela, Prof, Steen, Virginia, Prof, Müller-Ladner, Ulf, Prof, Lafyatis, Robert, MD, Stifano, Giuseppina, MD, Spotswood, Helen, PhD, Chen-Harris, Haiyin, PhD, Dziadek, Sebastian, PhD, Morimoto, Alyssa, PhD, Sornasse, Thierry, PhD, Siegel, Jeffrey, MD, Furst, Daniel E, Prof

“…Summary Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment options. The efficacy and safety of tocilizumab, an interleukin…”
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T cells in systemic sclerosis: a reappraisal by O'REILLY, Steven, HÜGLE, Thomas, LAAR, Jacob M. Van

“…SSc is an autoimmune disease characterized by inflammation and extracellular matrix deposition that ultimately leads to loss of organ function. T cells appear…”
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The clinical utility of bone marker measurements in osteoporosis by Wheater, Gillian, Elshahaly, Mohsen, Tuck, Stephen P, Datta, Harish K, van Laar, Jacob M

“…Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, resulting in increased fragility and susceptibility to fracture…”
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MiR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis by Ciechomska, Marzena, O'Reilly, Steven, Suwara, Monika, Bogunia-Kubik, Katarzyna, van Laar, Jacob M

“…Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by skin and internal organs fibrosis due to accumulation of extra cellular…”
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Characteristics of difficult-to-treat rheumatoid arthritis: results of an international survey by Roodenrijs, Nadia M T, de Hair, Maria J H, van der Goes, Marlies C, Jacobs, Johannes W G, Welsing, Paco M J, van der Heijde, Désirée, Aletaha, Daniel, Dougados, Maxime, Hyrich, Kimme L, McInnes, Iain B, Mueller-Ladner, Ulf, Senolt, Ladislav, Szekanecz, Zoltan, van Laar, Jacob M, Nagy, György

“…Patients with difficult-to-treat rheumatoid arthritis (RA) remain symptomatic despite treatment according to current European League Against Rheumatism (EULAR)…”
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Stem cells in the treatment of inflammatory arthritis by Tyndall, Alan, MD, van Laar, Jacob M., MD, PhD

“…Autologous haematopoietic stem cell transplantation in patients with rheumatoid arthritis (RA) resulted in a positive short-term outcome clinically with low…”
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Involvement of functional autoantibodies against vascular receptors in systemic sclerosis by Riemekasten, Gabriela, Philippe, Aurélie, Näther, Melanie, Slowinski, Torsten, Müller, Dominik N, Heidecke, Harald, Matucci-Cerinic, Marco, Czirják, László, Lukitsch, Ivo, Becker, Mike, Kill, Angela, van Laar, Jacob M, Catar, Rusan, Luft, Friedrich C, Burmester, Gerd R, Hegner, Björn, Dragun, Duska

“…Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue fibrosis. The renin-angiotensin and endothelin systems have been implicated in…”
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Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, results from an exploratory, prospective study by Wheater, Gillian, Elshahaly, Mohsen, Naraghi, Kamran, Tuck, Stephen P, Datta, Harish K, van Laar, Jacob M

“…Data describing the effect of in vivo B cell depletion on general bone loss in patients with rheumatoid arthritis (RA) are limited. Given the pathogenetic role…”
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Pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat rheumatoid arthritis: a systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis by Roodenrijs, Nadia M T, Hamar, Attila, Kedves, Melinda, Nagy, György, van Laar, Jacob M, van der Heijde, Désirée, Welsing, Paco M J

“…ObjectivesTo summarise, by a systematic literature review (SLR), the evidence regarding pharmacological and non-pharmacological therapeutic strategies in…”
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Design of TOLERANT: phase I/II safety assessment of intranodal administration of HSP70/mB29a self-peptide antigen-loaded autologous tolerogenic dendritic cells in patients with rheumatoid arthritis by Stoppelenburg, Arie Jan, Schreibelt, Gerty, Koeneman, Bouke, Welsing, Paco, Breman, Evert-Jan, Lammers, Laureen, de Goede, Anna, Duiveman-de Boer, Tjitske, van Eden, Willem, Leufkens, Paul, de Vries, I Jolanda M, Broere, Femke, van Laar, Jacob M

“…IntroductionIn rheumatoid arthritis (RA), immunosuppressive therapies may achieve symptomatic relief, but do not induce long-term, drug-free remission…”
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Identification and prediction of difficult-to-treat rheumatoid arthritis patients in structured and unstructured routine care data: results from a hackathon by Messelink, Marianne A, Roodenrijs, Nadia M. T, van Es, Bram, Hulsbergen-Veelken, Cornelia A. R, Jong, Sebastiaan, Overmars, L. Malin, Reteig, Leon C, Tan, Sander C, Tauber, Tjebbe, van Laar, Jacob M, Welsing, Paco M. J, Haitjema, Saskia

“…Abstract Background The new concept of difficult-to-treat rheumatoid arthritis (D2T RA) refers to RA patients who remain symptomatic after several lines of…”
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Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology by Teitsma, Xavier M, Yang, Wei, Jacobs, Johannes W G, Pethö-Schramm, Attila, Borm, Michelle E A, Harms, Amy C, Hankemeier, Thomas, van Laar, Jacob M, Bijlsma, Johannes W J, Lafeber, Floris P J G

“…We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with…”
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Author Correction: Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies by Pouw, Juliëtte N., Olde Nordkamp, Michel A. M., van Kempen, Tessa, Concepcion, Arno N., van Laar, Jacob M., van Wijk, Femke, Spierings, Julia, Leijten, Emmerik F. A., Boes, Marianne

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Optical spectral transmission to assess inflammation in hand and wrist joints of rheumatoid arthritis patients by Besselink, Nick J, van der Meijde, Patricia, Rensen, Wouter H J, Meijer, Peter B L, Marijnissen, Anne C A, van Laar, Jacob M, Lafeber, Floris P J G, Jacobs, Johannes W G

“…Abstract Objective To develop an optical spectral transmission (OST) model to measure joint inflammation, and thus disease activity, as well as to evaluate…”
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Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis by van Eden, Willem, Jansen, Manon A A, Ludwig, Irene S, Leufkens, Paul, van der Goes, Marlies C, van Laar, Jacob M, Broere, Femke

“…Technologies that enable induction of therapeutic tolerance may revolutionize the treatment of autoimmune diseases by their supposed potential to induce…”
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Automated CT quantification methods for the assessment of interstitial lung disease in collagen vascular diseases: A systematic review by van Royen, Florien S., Moll, Sofia A., van Laar, Jacob M., van Montfrans, Joris M., de Jong, Pim A., Mohamed Hoesein, Firdaus A.A.

“…•Interstitial lung disease (ILD) is common in collagen vascular disease patients.•ILD can be automatically quantified on CT using a histogram or texture…”
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