Search Results - "van Kuijk, K."

Smaller intercondylar notch size and smaller ACL volume increase posterior cruciate ligament rupture risk by van Kuijk, K. S. R., Reijman, M., Bierma-Zeinstra, S. M. A., Meuffels, D. E.

“…Purpose Little is known about risk factors for sustaining a posterior cruciate ligament (PCL) rupture. Identifying risk factors is the first step in preventing…”
Get full text

Posterior cruciate ligament injury is influenced by intercondylar shape and size of tibial eminence by K S R van Kuijk, Reijman, M, Bierma-Zeinstra, S M A, Waarsing, J H, Meuffels, D E

“…AimsLittle is known about the risk factors that predispose to a rupture of the posterior cruciate ligament (PCL). Identifying risk factors is the first step in…”
Get full text

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease by Demandt, J. A. F., Dubois, L. J., van Kuijk, K., Zaťovičová, M., Jin, H., Parkkila, S., van der Laan, S. W., Jelenska, L., Mees, B. M. E., Reutelingsperger, C. P. M., Cleutjens, K. B. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., van Greevenbroek, M. M. J., Biessen, E. A. L., Pasterkamp, G., Pastoreková, S., Stehouwer, C. D. A., Sluimer, J. C.

“…Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic…”
Get full text

Effect of Interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells by Shi, Q, Boots, A.W, Maas, L, Veith, C, van Kuijk, K, Haenen, G.R, Godschalk, R.W, Van Schooten, F.J

“…Abstract It has been well established that inflammation and concurrent mutagenic exposures drive the carcinogenic process in a synergistic way. To elucidate…”
Get full text

Knee shape might predict clinical outcome after an anterior cruciate ligament rupture by Eggerding, V, van Kuijk, K S R, van Meer, B L, Bierma-Zeinstra, S M A, van Arkel, E R A, Reijman, M, Waarsing, J H, Meuffels, D E

“…We have investigated whether shape of the knee can predict the clinical outcome of patients after an anterior cruciate ligament rupture. We used statistical…”
Get more information

Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing by van Kuijk, Kim, Kuppe, Christoph, Betsholtz, Christer, Vanlandewijck, Michael, Kramann, Rafael, Sluimer, Judith C

“…Abstract Cellular characteristics and their adjustment to a state of disease have become more evident due to recent advances in imaging, fluorescent reporter…”
Get full text

Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling by van Kuijk, Kim, Demandt, Jasper A F, Perales-Patón, Javier, Theelen, Thomas L, Kuppe, Christoph, Marsch, Elke, de Bruijn, Jenny, Jin, Han, Gijbels, Marion J, Matic, Ljubica, Mees, Barend M E, Reutelingsperger, Chris P M, Hedin, Ulf, Biessen, Erik A L, Carmeliet, Peter, Baker, Andrew H, Kramann, Rafael K, Schurgers, Leon J, Saez-Rodriguez, Julio, Sluimer, Judith C

“…Abstract Aims Atherosclerotic plaque hypoxia is detrimental for macrophage function. Prolyl hydroxylases (PHDs) initiate cellular hypoxic responses, possibly…”
Get full text

Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling by Van Kuijk, K., Demandt, J.A., Perales-Paton, J., Theelen, T., Marsch, E., De Bruijn, J., Kuppe, C., Mees, B., Gijbels, M.J.J., Matic, L., Hedin, U., Biessen, E., Kramann, R., Carmeliet, P., Schurgers, L.J., Saez-Rodriguez, J., Sluimer, J.

Get full text

Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype by Rademakers, Timo, Manca, Marco, Jin, Han, Orban, Tanguy, Perisic, Ljubica Matic, Frissen, Hubertus J. M., Rühle, Frank, Hautvast, Petra, van Rijssel, Jos, van Kuijk, Kim, Mees, Barend M. E., Peutz-Kootstra, Carine J., Heeneman, Sylvia, Daemen, Mat J. A. P., Pasterkamp, Gerard, Stoll, Monika, van Zandvoort, Marc A. M. J., Hedin, Ulf, Dequiedt, Franck, van Buul, Jaap D., Sluimer, Judith C., Biessen, Erik A. L.

“…The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of these…”
Get full text

The value of a standard CT of the spine, chest and abdomen after blunt trauma preliminary results of a prospective evaluation by Deunk, J, Brink, M, Edwards, M.J.R, Dekker, H.M, van Kuijk, K, van Vugt, A.B

Get full text

In-situ lipid alterations of aortic atherosclerosis in LDLR-deficient mice using mass spectrometry imaging by Martin-Lorenzo, M., Cao, J., Van Kuijk, K., Gijbels, M.J., Claes, B.S.R., Heeren, R.M.A., Sluimer, J., Alvarez-Llamas, G., Balluff, B.

Get full text

Partial Inhibition Of The Key Glycolytic Enzyme Pfkfb3 In Myeloid Cells Impacts Whole-Body Immune Cell And Liver Metabolism, But Not Atherogenesis by De Bruijn, J., van Kuijk, K., Bijnen, M., Gijbels, M., Wouters, K., Carmeliet, P., Sluimer, J.

Get full text

Single Cell Sequencing Reveals Heterogeneity Of Adventitial Mesenchymal Cells In Healthy Mice by van Kuijk, K., Dobie, R., Ramachandran, P., Taylor, R., Baker, A., Henderson, N., Sluimer, J.

Get full text

Pdgf-B Retention Motif Deletion Has Mural Cell-Independent Effects Including Leukocytosis And Increased Murine Atherosclerotic Plaque Stability Due To Macrophage Apoptosis And Decreased Mmp Activity by Tillie, R., Theelen, T., van Kuijk, K., Gijbels, M., Betsholtz, C., Daemen, M., Sluimer, J.

Get full text

Partial myeloid inhibition of key glycolytic enzyme PFKFB3 increases hepatic steatosis and inflammation, but does not affect atherosclerosis by Tillie, R., De Bruijn, J., Dobie, R., Perales-Patón, J., Van Kuijk, K., Gijbels, M., Temmerman, L., Ghosheh, Y., Goossens, G., Carmeliet, P., Ley, K., Henderson, N., Saez-Rodriguez, J., Wouters, K., Sluimer, J.

Get full text

Human and murine single-cell RNA-sequencing reveal fibroblast heterogeneity in healthy and diseased vasculature and differential regulation by ageing and serum cholesterol by Van Kuijk, K., Mccracken, I., Tillie, R., Asselberghs, S., Kheder, D., Muitjens, S., Jin, H., Taylor, R., Schreur, R. Wichers, Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M., Temmerman, L., Kirkwood, P., Luyten, J., Li, Y., Noels, H., Goossens, P., Wilson-Kanamori, J., Schurgers, L., Shen, Y., Mees, B., Biessen, E., Henderson, N., Kramann, R., Baker, A., Sluimer, J.

Get full text

Single cell sequencing reveals fibroblast heterogeneity in healthy and diseased vasculature by Van Kuijk, K., Mccracken, I., Tillie, R., Schreur, R. Wichers, Taylor, R., Dobie, R., Temmerman, L., Ramachamdran, P., Noels, H., Owens, G., Jin, H., Wilson-Kanamori, J., Mees, B., Biessen, E., Henderson, N., Baker, A., Sluimer, J.

Get full text

Myeloid Phd2 Knockdown Drives Macrophage Apoptosis And Paracrine Fibroblast/Smooth Muscle Cell Collagen Secretion Leading To Atherosclerotic Plaque Fibrosis by Van Kuijk, K., Theelen, T., Demandt, J., Marsch, E., Gijbels, M., Jin, H., Reutelingsperger, C., Cosemans, J., Schurgers, L., Carmeliet, P., Biessen, E., Daemen, M., Sluimer, J.

Get full text

Deficiency of myeloid prolyl hydroxylase domain proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling by Sluimer, J, Van Kuijk, K, Demandt, J A F, Perales-Paton, J, Kuppe, C, Jin, H, Matic, L, Mees, B, Hedin, U, Biessen, E A L, Carmeliet, P, Baker, A H, Kramann, R K, Schurgers, L J, Saez-Rodriguez, J

“…Abstract Background Atherosclerotic plaque hypoxia is detrimental for macrophage function. Prolyl hydroxylases (PHDs) initiate cellular hypoxic responses,…”
Get full text

Integrative multiomics analysis of human atherosclerosis reveals a serum response factor‐driven network associated with intraplaque hemorrhage by Jin, Han, Goossens, Pieter, Juhasz, Peter, Eijgelaar, Wouter, Manca, Marco, Karel, Joël M. H., Smirnov, Evgueni, Sikkink, Cornelis J. J. M., Mees, Barend M. E., Waring, Olivia, van Kuijk, Kim, Fazzi, Gregorio E., Gijbels, Marion J. J., Kutmon, Martina, Evelo, Chris T. A., Hedin, Ulf, Daemen, Mat J. A. P., Sluimer, Judith C., Matic, Ljubica, Biessen, Erik A. L.

“…Background While single‐omics analyses on human atherosclerotic plaque have been very useful to map stage‐ or disease‐related differences in expression, they…”
Get full text