Search Results - "van Krieken, Han J."

Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer by Van Cutsem, Eric, Lenz, Heinz-Josef, Köhne, Claus-Henning, Heinemann, Volker, Tejpar, Sabine, Melezínek, Ivan, Beier, Frank, Stroh, Christopher, Rougier, Philippe, van Krieken, J Han, Ciardiello, Fortunato

“…The phase III CRYSTAL study demonstrated that addition of cetuximab to fluorouracil, leucovorin, and irinotecan (FOLFIRI) significantly improved overall…”
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The tumour–stroma ratio in colon cancer: the biological role and its prognostic impact by Pelt, Gabi W, Sandberg, Tessa P, Morreau, Hans, Gelderblom, Hans, Krieken, J Han J M, Tollenaar, Rob A E M, Mesker, Wilma E

“…The tumour microenvironment consists of a complex mixture of non‐neoplastic cells, including fibroblasts, immune cells and endothelial cells embedded in the…”
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A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer by Weren, Robbert D A, Ligtenberg, Marjolijn J L, Kets, C Marleen, de Voer, Richarda M, Verwiel, Eugène T P, Spruijt, Liesbeth, van Zelst-Stams, Wendy A G, Jongmans, Marjolijn C, Gilissen, Christian, Hehir-Kwa, Jayne Y, Hoischen, Alexander, Shendure, Jay, Boyle, Evan A, Kamping, Eveline J, Nagtegaal, Iris D, Tops, Bastiaan B J, Nagengast, Fokko M, Geurts van Kessel, Ad, van Krieken, J Han J M, Kuiper, Roland P, Hoogerbrugge, Nicoline

“…Roland Kuiper and colleagues identify a homozygous germline nonsense mutation in the base-excision repair gene NTHL1 in three families with recessive…”
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Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma by Flucke, Uta, van Krieken, J Han JM, Mentzel, Thomas

“…Cellular angiofibroma represents a rare benign mesenchymal tumor, occurring mainly in the superficial soft tissue of the genital region. The involvement of…”
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Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1 by van Kessel, Ad Geurts, Hoenselaar, Eveline, Voorendt, Marsha, Kuiper, Roland P, Lee, Tracy Y H, Hendriks-Cornelissen, Sandra J B, Yuen, Siu Tsan, van Krieken, J Han J M, Leung, Suet Yi, Hoogerbrugge, Nicoline, Chan, Tsun Leung, Bodmer, Danielle, Ligtenberg, Marjolijn J L, Goossens, Monique, Hebeda, Konnie M, Tsui, Wai Yin, Brunner, Han G, Kong, Chi Kwan

“…Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to inactivating germline mutations in mismatch repair genes, including MSH2…”
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Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients by van de Weerd, Simone, Smit, Marloes A, Roelands, Jessica, Mesker, Wilma E, Bedognetti, Davide, Kuppen, Peter J K, Putter, Hein, Tollenaar, Rob A E M, Roodhart, Jeanine M L, Hendrickx, Wouter, Medema, Jan Paul, van Krieken, J Han J M

“…The purpose of this study was to evaluate the association between four distinct histopathological features: (1) tumor infiltrating lymphocytes, (2) mucinous…”
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Tumour-stroma ratio outperforms tumour budding as biomarker in colon cancer: a cohort study by Smit, Marloes A., van Pelt, Gabi W., Terpstra, Valeska, Putter, Hein, Tollenaar, Rob A. E. M., Mesker, Wilma E., van Krieken, J. Han J. M.

“…The tumour-stroma ratio (TSR) and tumour budding (TB) are two high-risk factors with potential to be implemented in the next TNM classification. The aim of the…”
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Clonality assessment and detection of clonal diversity in classic Hodgkin lymphoma by next-generation sequencing of immunoglobulin gene rearrangements by van Bladel, Diede A.G., van den Brand, Michiel, Rijntjes, Jos, Pamidimarri Naga, Samhita, Haacke, Demi L.C.M., Luijks, Jeroen A.C.W., Hebeda, Konnie M., van Krieken, J. Han J.M., Groenen, Patricia J.T.A., Scheijen, Blanca

“…Clonality analysis in classic Hodgkin lymphoma (cHL) is of added value for correctly diagnosing patients with atypical presentation or histology reminiscent of…”
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External Quality Assessment Unravels Interlaboratory Differences in Quality of RAS Testing for Anti‐EGFR Therapy in Colorectal Cancer by Tack, Véronique, Ligtenberg, Marjolijn J.L., Tembuyser, Lien, Normanno, Nicola, Vander Borght, Sara, Han van Krieken, J., Dequeker, Elisabeth M.C.

“…Background. Regulations for the selection of patients with metastatic colorectal cancer for anti‐EGFR treatment changed at the end of 2013. The set of…”
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Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation by JONGMANS, Marjolijn C. J, VAN DER BURGT, Ineke, KIEMENEY, Lambertus A. L. M, HOOGERBRUGGE, Nicoline, HOOGERBRUGGE, Peter M, NOORDAM, Kees, YNTEMA, Helger G, NILLESEN, Willy M, KUIPER, Roland P, LIGTENBERG, Marjolijn J. L, VAN KESSEL, Ad Geurts, VAN KRIEKEN, J. Han J. M

“…Noonan syndrome (NS) is characterized by short stature, facial dysmorphisms and congenital heart defects. PTPN11 mutations are the most common cause of NS…”
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Confirmation of a metastasis-specific microRNA signature in primary colon cancer by Coebergh van den Braak, Robert R. J, Sieuwerts, Anieta M., Lalmahomed, Zarina S., Smid, Marcel, Wilting, Saskia M., Bril, Sandra I., Xiang, Shanshan, van der Vlugt-Daane, Michelle, de Weerd, Vanja, van Galen, Anne, Biermann, Katharina, van Krieken, J. Han J. M, Kloosterman, Wigard P., Foekens, John A., Martens, John W. M., IJzermans, Jan N. M.

“…The identification of patients with high-risk stage II colon cancer who may benefit from adjuvant therapy may allow the clinical approach to be tailored for…”
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Role of germline aberrations affecting CTNNA1 , MAP3K6 and MYD88 in gastric cancer susceptibility by Weren, Robbert D A, van der Post, Rachel S, Vogelaar, Ingrid P, van Krieken, J Han, Spruijt, Liesbeth, Lubinski, Jan, Jakubowska, Anna, Teodorczyk, Urszula, Aalfs, Cora M, van Hest, Liselotte P, Oliveira, Carla, Kamping, Eveline J, Schackert, Hans K, Ranzani, Guglielmina N, Gómez García, Encarna B, Hes, Frederik J, Holinski-Feder, Elke, Genuardi, Maurizio, Ausems, Margreet G E M, Sijmons, Rolf H, Wagner, Anja, van der Kolk, Lizet E, Cats, Annemieke, Bjørnevoll, Inga, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J L

“…In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline mutation; however, in…”
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Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteria by van der Post, Rachel S., MD, van Dieren, Jolanda, MD, PhD, Grelack, Anna, MD, Hoogerbrugge, Nicoline, MD, PhD, van der Kolk, Lizet E., MD, PhD, Snaebjornsson, Petur, MD, PhD, Lansdorp-Vogelaar, Iris, PhD, van Krieken, J. Han, MD, PhD, Bisseling, Tanya M., MD, PhD, Cats, Annemieke, MD, PhD

“…Background and Aims The aim of this study was to determine the yield of endoscopic screening in first-degree relatives (FDRs) of CDH1 -negative hereditary…”
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RAS testing in metastatic colorectal cancer: advances in Europe by Van Krieken, J Han JM, Rouleau, Etienne, Ligtenberg, Marjolijn J. L., Normanno, Nicola, Patterson, Scott D., Jung, Andreas

“…Personalized medicine shows promise for maximizing efficacy and minimizing toxicity of anti-cancer treatment. KRAS exon 2 mutations are predictive of…”
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Gene-Expression and Immunohistochemical Study of Specific T-Cell Subsets and Accessory Cell Types in the Transformation and Prognosis of Follicular Lymphoma by GLAS, Annuska M, KNOOPS, Laurent, KLUIN, Philip M, VAN 'T VEER, Laura J, DE JONG, Daphne, DELAHAYE, Leonie, KERSTEN, Marie José, KIBBELAAR, Robby E, WESSELS, Lodewyk A, VAN LAAR, Ryan, VAN KRIEKEN, J. Han J. M, BAARS, Joke W, RAEMAEKERS, John

“…Despite the generally favorable clinical course in follicular lymphoma (FL), a minority of patients have a poor prognosis-with death within 3 years of…”
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Germline Mutations in the Spindle Assembly Checkpoint Genes BUB1 and BUB3 Are Risk Factors for Colorectal Cancer by de Voer, Richarda M, Geurts van Kessel, Ad, Weren, Robbert D.A, Ligtenberg, Marjolijn J.L, Smeets, Dominique, Fu, Lei, Vreede, Lilian, Kamping, Eveline J, Verwiel, Eugène T.P, Hahn, Marc–Manuel, Ariaans, Maayke, Spruijt, Liesbeth, van Essen, Ton, Houge, Gunnar, Schackert, Hans K, Sheng, Jian Q, Venselaar, Hanka, van Ravenswaaij–Arts, Conny M.A, van Krieken, J. Han J.M, Hoogerbrugge, Nicoline, Kuiper, Roland P

“…The spindle assembly checkpoint controls proper chromosome segregation during mitosis and prevents aneuploidy—an important feature of cancer cells. We…”
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Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review by van den Brand, Michiel, van Krieken, J Han J M

“…The diagnosis of nodal marginal zone lymphoma is one of the remaining problem areas in hematopathology. Because no established positive markers exist for this…”
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Novel Approaches in Molecular Characterization of Classical Hodgkin Lymphoma by van Bladel, Diede A. G., Stevens, Wendy B. C., van den Brand, Michiel, Kroeze, Leonie I., Groenen, Patricia J. T. A., van Krieken, J. Han J. M., Hebeda, Konnie M., Scheijen, Blanca

“…Classical Hodgkin lymphoma (cHL) represents a B-cell lymphoproliferative disease characterized by clonal immunoglobulin gene rearrangements and recurrent…”
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Circumferential Margin Involvement Is the Crucial Prognostic Factor after Multimodality Treatment in Patients with Locally Advanced Rectal Carcinoma by GOSENS, Marleen J. E. M, KLAASSEN, René A, TAN-GO, Ivonne, RUTTEN, Harm J. T, MARTIJN, Hendrik, VAN DEN BRULE, Adriaan J. C, NIEUWENHUIJZEN, Grard A. P, VAN KRIEKEN, J. Han J. M, NAGTEGAAL, Iris D

“…Purpose: After preoperative (radio)chemotherapy, histologic determinants for prognostification have changed. It is unclear which variables, including…”
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Identification of candidate predisposing copy number variants in familial and early‐onset colorectal cancer patients by Venkatachalam, Ramprasath, Verwiel, Eugène T.P., Kamping, Eveline J., Hoenselaar, Eveline, Görgens, Heike, Schackert, Hans K., van Krieken, J. Han J.M., Ligtenberg, Marjolijn J.L., Hoogerbrugge, Nicoline, van Kessel, Ad Geurts, Kuiper, Roland P.

“…In the majority of colorectal cancers (CRCs) under clinical suspicion for a hereditary cause, the disease‐causing genetic factors are still to be discovered…”
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