Search Results - "van Kleef, Nadine D"

S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation by Sprenkeler, Evelien G G, Zandstra, Judith, van Kleef, Nadine D, Goetschalckx, Ines, Verstegen, Bibian, Aarts, Cathelijn E M, Janssen, Hans, Tool, Anton T J, van Mierlo, Gerard, van Bruggen, Robin, Jongerius, Ilse, Kuijpers, Taco W

“…Neutrophils are the most abundant innate immune cells in the circulation and they are the first cells recruited to sites of infection or inflammation. Almost…”
Get full text

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy by Lischer, Christopher, Eberhardt, Martin, Flamann, Cindy, Berges, Johannes, Güse, Esther, Wessely, Anja, Weich, Adrian, Retzlaff, Jimmy, Dörrie, Jan, Schaft, Niels, Wiesinger, Manuel, März, Johannes, Schuler-Thurner, Beatrice, Knorr, Harald, Gupta, Shailendra, Singh, Krishna Pal, Schuler, Gerold, Heppt, Markus Vincent, Koch, Elias Andreas Thomas, van Kleef, Nadine D, Freen-van Heeren, Julian J, Turksma, Annelies W, Wolkenhauer, Olaf, Hohberger, Bettina, Berking, Carola, Bruns, Heiko, Vera, Julio

“…BackgroundTumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer…”
Get full text

Nanomedicine platform for targeting activated neutrophils and neutrophil–platelet complexes using an α1-antitrypsin-derived peptide motif by Cruz, Michelle A., Bohinc, Dillon, Andraska, Elizabeth A., Alvikas, Jurgis, Raghunathan, Shruti, Masters, Nicole A., van Kleef, Nadine D., Bane, Kara L., Hart, Kathryn, Medrow, Kathryn, Sun, Michael, Liu, Haitao, Haldeman, Shannon, Banerjee, Ankush, Lessieur, Emma M., Hageman, Kara, Gandhi, Agharnan, de la Fuente, Maria, Nieman, Marvin T., Kern, Timothy S., Maas, Coen, de Maat, Steven, Neeves, Keith B., Neal, Matthew D., Sen Gupta, Anirban, Stavrou, Evi X.

“…Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune…”
Get full text

A reactive center loop–based prediction platform to enhance the design of therapeutic SERPINs by Sanrattana, Wariya, Sefiane, Thibaud, Smits, Simone, van Kleef, Nadine D., Fens, Marcel H., Lenting, Peter J., Maas, Coen, de Maat, Steven

“…Serine proteases are essential for many physiological processes and require tight regulation by serine protease inhibitors (SERPINs). A disturbed…”
Get full text

Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis by de Maat, Steven, Clark, Chantal C., Barendrecht, Arjan D., Smits, Simone, van Kleef, Nadine D., El Otmani, Hinde, Waning, Manon, van Moorsel, Marc, Szardenings, Michael, Delaroque, Nicolas, Vercruysse, Kristof, Urbanus, Rolf T., Sebastian, Silvie, Lenting, Peter J., Hagemeyer, Christoph, Renné, Thomas, Vanhoorelbeke, Karen, Tersteeg, Claudia, Maas, Coen

“…Thrombotic microangiopathies are hallmarked by attacks of disseminated microvascular thrombosis. In thrombotic thrombocytopenic purpura (TTP), this is caused…”
Get full text

Targeted SERPIN (TaSER): A dual‐action antithrombotic agent that targets platelets for SERPIN delivery by Sanrattana, Wariya, Smits, Simone, Barendrecht, Arjan D., Kleef, Nadine D., El Otmani, Hinde, Zivkovic, Minka, Roest, Mark, Renné, Thomas, Clark, Chantal C., Maat, Steven, Maas, Coen

“…Background Occlusive thrombi are not homogeneous in composition. The core of a thrombus is rich in activated platelets and fibrin while the outer shell…”
Get full text

VhH anti‐thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow by van Moorsel, Marc V. A., Poolen, Geke C., Koekman, Cornelis A., Verhoef, Sandra, de Maat, Steven, Barendrecht, Arjan, van Kleef, Nadine D., Meijers, Joost C. M., Schiffelers, Raymond M., Maas, Coen, Urbanus, Rolf T.

“…Background Thrombomodulin on endothelial cells can form a complex with thrombin. This complex has both anticoagulant properties, by activating protein C, and…”
Get full text

Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID‐19, not entirely explaining the increased risk of thrombosis by Vries, Judith J., Visser, Chantal, Geers, Lotte, Slotman, Johan A., van Kleef, Nadine D., Maas, Coen, Bax, Hannelore I., Miedema, Jelle R., Gorp, Eric C. M., Goeijenbier, Marco, Akker, Johannes P. C., Endeman, Henrik, Rijken, Dingeman C., Kruip, Marieke J. H. A., Maat, Moniek P. M.

“…Background Severe acute respiratory syndrome coronavirus 2 infection is associated with an increased incidence of thrombosis. Objectives By studying the fibrin…”
Get full text

Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α 1 -antitrypsin-derived peptide motif by Cruz, Michelle A, Bohinc, Dillon, Andraska, Elizabeth A, Alvikas, Jurgis, Raghunathan, Shruti, Masters, Nicole A, van Kleef, Nadine D, Bane, Kara L, Hart, Kathryn, Medrow, Kathryn, Sun, Michael, Liu, Haitao, Haldeman, Shannon, Banerjee, Ankush, Lessieur, Emma M, Hageman, Kara, Gandhi, Agharnan, de la Fuente, Maria, Nieman, Marvin T, Kern, Timothy S, Maas, Coen, de Maat, Steven, Neeves, Keith B, Neal, Matthew D, Sen Gupta, Anirban, Stavrou, Evi X

“…Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune…”
Get full text