Search Results - "van Kesteren, Petra C.E."

DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance? by van Kesteren, Petra C.E., Beems, Rudolf B., Luijten, Mirjam, Robinson, Joke, de Vries, Annemieke, van Steeg, Harry

“…The DNA repair-deficient Xpa−/−p53+/− (Xpa/p53) mouse is a potent model for carcinogenicity testing, representing increased sensitivity toward genotoxic but…”
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Overview of potential adverse health effects of oral exposure to nanocellulose by Brand, Walter, van Kesteren, Petra C. E., Swart, Elmer, Oomen, Agnes G.

“…Nanocellulose is an emerging material for which several food-related applications are foreseen, for example, novel food, functional food, food additive or in…”
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Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure by Brand, Walter, van Kesteren, Petra C. E., Peters, Ruud J. B., Oomen, Agnes G.

“…Synthetic amorphous silica (SAS) is applied in food products as food additive E 551. It consists of constituent amorphous silicon dioxide (SiO 2 )…”
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Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food by van Kesteren, Petra C. E., Cubadda, Francesco, Bouwmeester, Hans, van Eijkeren, Jan C. H., Dekkers, Susan, de Jong, Wim H., Oomen, Agnes G.

“…Abstract This study presents novel insights in the risk assessment of synthetic amorphous silica (SAS) in food. SAS is a nanostructured material consisting of…”
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The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials by Bos, Peter M J, Gottardo, Stefania, Scott-Fordsmand, Janeck J, van Tongeren, Martie, Semenzin, Elena, Fernandes, Teresa F, Hristozov, Danail, Hund-Rinke, Kerstin, Hunt, Neil, Irfan, Muhammad-Adeel, Landsiedel, Robert, Peijnenburg, Willie J G M, Sánchez Jiménez, Araceli, van Kesteren, Petra C E, Oomen, Agnes G

“…An engineered nanomaterial (ENM) may actually consist of a population of primary particles, aggregates and agglomerates of various sizes. Furthermore, their…”
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Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene by van Kesteren, Petra C E, Zwart, P Edwin, Pennings, Jeroen L A, Gottschalk, W H Ralph, Kleinjans, Jos C S, van Delft, Joost H, van Steeg, Harry, Luijten, Mirjam

“…The current method to predict carcinogenicity of chemicals or drugs is the chronic 2-year rodent bioassay, which has disadvantages in duration, animal use, and…”
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Implementation of toxicokinetics in toxicity studies – Toxicokinetics of 4-methylanisole and its metabolites in juvenile and adult rats by Brandon, Esther F.A., van Kesteren, Petra C.E., van Eijkeren, Jan C.H., Tienstra, Marc, Sanchez, Patricia Lopez, Tonk, Elisa C.M., Piersma, Aldert H., Bos, Peter M.J.

“…The current risk assessment of compounds is generally based on external exposure and effect relationships. External doses are often not representative for…”
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