Search Results - "van Kempen, Léon C. L. T."

Pelvic organ prolapse and collagen-associated disorders by Lammers, Karin, Lince, Sabrina L., Spath, Marian A., van Kempen, Léon C. L. T., Hendriks, Jan C. M., Vierhout, Mark E., Kluivers, Kirsten B.

“…Introduction and hypothesis Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes…”
Get full text

Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue by van de Nieuwenhof, Hedwig P., de Hullu, Joanne A., Kaanders, Johannes H. A. M., Bulten, Johan, Massuger, Leon F. A. G., van Kempen, Léon C. L. T.

“…Intratumoral hypoxia has been associated with poor prognosis in several solid tumors. The aim of this study was to determine whether the hypoxia-associated…”
Get full text

Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma by van Kempen, Léon C.L.T., Rijntjes, Jos, Mamor‐Cornelissen, Ine, Vincent‐Naulleau, Silvia, Gerritsen, Marie‐Jeanne P., Ruiter, Dirk J., van Dijk, Marcory C.R.F., Geffrotin, Claudine, van Muijen, Goos N.P.

“…Tumors are complex tissues composed of neoplastic cells, soluble and insoluble matrix components and stromal cells. Here we report that in melanoma, turn‐over…”
Get full text

Modulation of Activated Leukocyte Cell Adhesion Molecule–Mediated Invasion Triggers an Innate Immune Gene Response in Melanoma by van Kilsdonk, Jeroen W.J., Takahashi, Nozomi, Weidle, Ulrich, Burtscher, Helmut, Jarry, Jonathan, Daha, Mohamed R., Swart, Guido W.M., van Kempen, Léon C.L.T.

“…Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a progression marker of a variety of cancers, including melanoma, and is a marker for mesenchymal…”
Get full text

Truncation of Activated Leukocyte Cell Adhesion Molecule: A Gateway to Melanoma Metastasis by van Kempen, Léon C.L.T., Meier, Friedegund, Egeblad, Mikala, Kersten-Niessen, Monique J.F., Garbe, Claus, Weidle, Ulrich H., van Muijen, Goos N.P., Herlyn, Meenhard, Bloemers, Henri P.J., Swart, Guido W.M.

“…Progression of human cutaneous primary melanoma is, among others, accompanied by de novo expression of activated leukocyte cell adhesion molecule (ALCAM/CD166)…”
Get full text

Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma by van de Nieuwenhof, Hedwig P, Bulten, Johan, Hollema, Harrie, Dommerholt, Rianne G, Massuger, Leon F A G, van der Zee, Ate G J, de Hullu, Joanne A, van Kempen, Leon C L T

“…Lichen sclerosus is considered to be the precursor lesion of vulvar squamous cell carcinoma, of which only 2–5% progress to squamous cell carcinoma…”
Get full text

Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age by van de Nieuwenhof, Hedwig P, Massuger, Leon F.A.G, van der Avoort, Irene A.M, Bekkers, Ruud L.M, Casparie, Mariel, Abma, Wim, van Kempen, Léon C.L.T, de Hullu, Joanne A

“…Abstract Objective The purpose of the present study is to investigate the trends in incidence of both usual (u) and differentiated (d) vulvar intraepithelial…”
Get full text

The Etiologic Role of HPV in Vulvar Squamous Cell Carcinoma Fine Tuned by VAN DE NIEUWENHOF, Hedwig P, VAN KEMPEN, Léon C. L. T, DE HULLU, Joanne A, BEKKERS, Ruud L. M, BULTEN, Johan, MELCHERS, Willem J. G, MASSUGER, Leon F. A. G

“…Purpose: High-risk human papilloma virus (HPV) plays a role in the development of a subset of vulvar squamous cell carcinomas. Uncertainty exists about the…”
Get full text

The tumor microenvironment: a critical determinant of neoplastic evolution by van Kempen, Léon C.L.T., Ruiter, Dirk J., van Muijen, Goos N.P., Coussens, Lisa M.

“…Evolution of neoplastic cells has generally been regarded as a cumulative intrinsic process resulting in altered cell characteristics enabling enhanced growth…”
Get full text

Activated leukocyte cell adhesion molecule (ALCAM/CD166): signaling at the divide of melanoma cell clustering and cell migration? by Swart, Guido W M, Lunter, Pim C, Kilsdonk, Jeroen W J van, Kempen, Leon C L T van

“…Orchestrated modulation of cell adhesion is essential for development and homeostasis in multicellular organisms. It optimizes embedding of the cell in its…”
Get full text

Activated Leukocyte Cell Adhesion Molecule/CD166, a Marker of Tumor Progression in Primary Malignant Melanoma of the Skin by van Kempen, Léon C.L.T., van den Oord, Joost J., van Muijen, Goos N.P., Weidle, Ulrich H., Bloemers, Henri P.J., Swart, Guido W.M.

“…Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am…”
Get full text

High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva by van der Avoort, Irene A.M., MD, MSc, van de Nieuwenhof, Hedwig P., MD, Otte-Höller, Irene, MSc, Nirmala, Ella, BSc, Bulten, Johan, MD, PhD, Massuger, Leon F.A.G., MD, PhD, van der Laak, Jeroen A.W.M., PhD, Slootweg, Piet J., MD, PhD, de Hullu, Joanne A., MD, PhD, van Kempen, Léon C.L.T., PhD

“…Summary The molecular pathogenesis of human papilloma virus–unrelated vulvar squamous cell carcinoma is not well known. Whether malignant progression of lichen…”
Get full text

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity by Conde-Perez, Alejandro, Gros, Gwendoline, Longvert, Christine, Pedersen, Malin, Petit, Valérie, Aktary, Zackie, Viros, Amaya, Gesbert, Franck, Delmas, Véronique, Rambow, Florian, Bastian, Boris C., Campbell, Andrew D., Colombo, Sophie, Puig, Isabel, Bellacosa, Alfonso, Sansom, Owen, Marais, Richard, Van Kempen, Leon C. L. T., Larue, Lionel

“…Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN…”
Get full text

The prognostic value of blood and lymph vessel parameters in lichen sclerosus for vulvar squamous cell carcinoma development: an immunohistochemical and electron microscopy study by van der Avoort, Irene A.M., MD, MSc, van der Laak, Jeroen A.W.M., PhD, Otte-Höller, Irene, MSc, van de Nieuwenhof, Hedwig P., MD, MSc, Massuger, Leon F.A.G., MD, PhD, de Hullu, Joanne A., MD, PhD, van Kempen, Léon C.L.T., PhD

“…Objective The objective of the study was to quantify vessel type and density in lichen sclerosus (LS) to find a marker for its malignant potential. Study…”
Get full text

Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma by van Kempen, Léon CLT, Rijntjes, Jos, Claes, An, Blokx, Willeke AM, Gerritsen, Marie-Jeanne P, Ruiter, Dirk J, van Muijen, Goos NP

“…Neoplastic progression of solid tumours is often characterized by a simultaneous increase in matrix protein (eg collagen) synthesis and degradation, and…”
Get full text

Reactive oxygen species in melanoma and its therapeutic implications by Wittgen, Hanneke G M, van Kempen, Léon C L T

“…Oxidative phosphorylation in the mitochondria is an important energy-producing process for eukaryotic cells, but this process can also result in producing…”
Get full text

Serous Tubal Intraepithelial Carcinoma After Neoadjuvant Chemotherapy: A Report of 2 Cases by Stroot, Iris A S, Smit, Leonie, de Bock, Geertruida H, Wagner, Marise M, Jalving, Mathilde, van Kempen, Léon C L T, Bart, Joost, Mourits, Marian J E

“…Serous tubal intraepithelial carcinoma (STIC) is regarded as the origin of most high-grade serous carcinomas (HGSC). After a diagnosis of isolated STIC, risk…”
Get full text

Soluble adhesion molecules in human cancers: Sources and fates by van Kilsdonk, Jeroen W.J., van Kempen, Léon C.L.T., van Muijen, Goos N.P., Ruiter, Dirk J., Swart, Guido W.M.

“…Adhesion molecules endow tumor cells with the necessary cell-cell contacts and cell-matrix interactions. As such, adhesion molecules are involved in cell…”
Get full text

Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule by van Kilsdonk, Jeroen W J, Wilting, Roel H, Bergers, Mieke, van Muijen, Goos N P, Schalkwijk, Joost, van Kempen, Léon C L T, Swart, Guido W M

“…Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is involved in melanoma metastasis. We…”
Get full text

Keratinocytes drive melanoma invasion in a reconstructed skin model by Van Kilsdonk, Jeroen W J, Bergers, Mieke, Van Kempen, Léon C L T, Schalkwijk, Joost, Swart, Guido W M

“…Melanoma progression is a multistep progression from a common melanocytic nevus through the radial growth phase, the invasive vertical growth phase finally…”
Get full text