Search Results - "van Ijcken, W."

Inflammatory conditions affect gene expression and function of human adipose tissue‐derived mesenchymal stem cells by Crop, M.J, Baan, C.C, Korevaar, S.S, IJzermans, J.N.M, Pescatori, M, Stubbs, A.P, Van IJcken, W.F.J, Dahlke, M.H, Eggenhofer, E, Weimar, W, Hoogduijn, M.J

“…There is emerging interest in the application of mesenchymal stem cells (MSC) for the prevention and treatment of autoimmune diseases, graft‐versus‐host…”
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miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells by van Jaarsveld, M T M, Helleman, J, Boersma, A W M, van Kuijk, P F, van IJcken, W F, Despierre, E, Vergote, I, Mathijssen, R H J, Berns, E M J J, Verweij, J, Pothof, J, Wiemer, E A C

“…Epithelial ovarian cancer is the most lethal gynecological malignancy in the Western world. A major impediment for the successful treatment is the development…”
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Hemolysis in the spleen drives erythrocyte turnover by Klei, T.R.L, Dalimot, J., Nota, B., Veldthuis, M., Mul, F.P.J, Rademakers, T., Hoogenboezem, M., Nagelkerke, S.Q., van IJcken, W.F.J, Oole, E., Svendsen, P., Moestrup, S.K., van Alphen, F.P.J, Meijer, A.B., Kuijpers, T.W., van Zwieten, R., van Bruggen, R.

“…Red pulp macrophages (RPMs) of the spleen mediate turnover of billions of senescent erythrocytes per day. However, the molecular mechanisms involved in…”
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Bio-distribution and longevity of mesenchymal stromal cell derived membrane particles by Vos, J., Tejeda-Mora, H., Merino, A., Wu, L., Woud, W.W., Demmers, J.A.A., van IJcken, W.F.J., Reinders, M.E.J., Hoogduijn, M.J.

“…Vesicle-based medicines hold great promise for therapy development but essential knowledge on the bio-distribution and longevity of vesicles after…”
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Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms by Amin, N, Jovanova, O, Adams, H H H, Dehghan, A, Kavousi, M, Vernooij, M W, Peeters, R P, de Vrij, F M S, van der Lee, S J, van Rooij, J G J, van Leeuwen, E M, Chaker, L, Demirkan, A, Hofman, A, Brouwer, R W W, Kraaij, R, Willems van Dijk, K, Hankemeier, T, van Ijcken, W F J, Uitterlinden, A G, Niessen, W J, Franco, O H, Kushner, S A, Ikram, M A, Tiemeier, H, van Duijn, C M

“…Despite a substantial genetic component, efforts to identify common genetic variation underlying depression have largely been unsuccessful. In the current…”
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The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins by Edel, G. G, van Kempen, M, Munck, A. Boerema-de, Huisman, C. N, Naalden, C. A. P, Brouwer, R. W. W, Koornneef, S, van IJcken, W. F. J, Wijnen, R. M. H, Rottier, R. J

“…Abstract Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly associated with…”
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Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia by Schotte, D, Moqadam, F Akbari, Lange-Turenhout, E A M, Chen, C, van IJcken, W F J, Pieters, R, den Boer, M L

“…MicroRNAs (miRNAs) relevant to acute lymphoblastic leukemia (ALL) in children are hypothesized to be largely unknown as most miRNAs have been identified in…”
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A rare missense variant in RCL1 segregates with depression in extended families by Amin, N, de Vrij, F M S, Baghdadi, M, Brouwer, R W W, van Rooij, J G J, Jovanova, O, Uitterlinden, A G, Hofman, A, Janssen, H L A, Darwish Murad, S, Kraaij, R, Stedehouder, J, van den Hout, M C G N, Kros, J M, van IJcken, W F J, Tiemeier, H, Kushner, S A, van Duijn, C M

“…Depression is the most prevalent psychiatric disorder with a complex and elusive etiology that is moderately heritable. Identification of genes would greatly…”
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MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours by Gits, C M M, van Kuijk, P F, Jonkers, M B E, Boersma, A W M, van IJcken, W F, Wozniak, A, Sciot, R, Rutkowski, P, Schöffski, P, Taguchi, T, Mathijssen, R H J, Verweij, J, Sleijfer, S, Debiec-Rychter, M, Wiemer, E A C

“…Background: Gastrointestinal stromal tumours (GIST) are characterised by high expression of KIT and ETV1, which cooperate in GIST oncogenesis. Our aim was to…”
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Progression of ductal carcinoma in situ to invasive breast cancer: comparative genomic sequencing by Doebar, S. C., Krol, N. M., van Marion, R., Brouwer, R. W. W., van Ijcken, W. F. J., Martens, J. M., Dinjens, W. N. M., van Deurzen, C. H. M.

“…Several models have been described as potential mechanisms for the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC). The aim of…”
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Exploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis by Tyc, Olaf, Kulkarni, Purva, Ossowicki, Adam, Tracanna, Vittorio, Medema, Marnix H, van Baarlen, Peter, van IJcken, W F J, Verhoeven, Koen J F, Garbeva, Paolina

“…Microbial community analysis of aquatic environments showed that an important component of its microbial diversity consists of bacteria with cell sizes of ~0.1…”
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Regulated genes in psoriatic skin during treatment with fumaric acid esters by Onderdijk, A.J., Balak, D.M.W., Baerveldt, E.M., Florencia, E.F., Kant, M., Laman, J.D., van IJcken, W.F.J., Racz, E., de Ridder, D., Thio, H.B., Prens, E.P.

“…Summary Background Fumaric acid esters (FAEs) are widely used in Europe for the treatment of psoriasis because of their clinical efficacy and favourable safety…”
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Nimbus: a design-driven analyses suite for amplicon-based NGS data by Brouwer, R W W, van den Hout, M C G N, Kockx, C E M, Brosens, E, Eussen, B, de Klein, A, Sleutels, F, van IJcken, W F J

“…Abstract Motivation PCR-based DNA enrichment followed by massively parallel sequencing is a straightforward and cost effective method to sequence genes up to…”
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NARWHAL, a primary analysis pipeline for NGS data by Brouwer, R. W. W., van den Hout, M. C. G. N., Grosveld, F. G., van IJcken, W. F. J.

“…The NARWHAL software pipeline has been developed to automate the primary analysis of Illumina sequencing data. This pipeline combines a new and flexible…”
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Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue by Weerts, M. J. A., Timmermans, E. C., Vossen, R. H. A. M., van Strijp, D., Van den Hout–van Vroonhoven, M. C. G. N., van IJcken, W. F. J., van der Zaag, P. J., Anvar, S. Y., Sleijfer, S., Martens, J. W. M.

“…Large variation exists in mitochondrial DNA (mtDNA) not only between but also within individuals. Also in human cancer, tumor-specific mtDNA variation exists…”
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Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort by Amin, N, de Vrij, F M S, Baghdadi, M, Brouwer, R W W, van Rooij, J G J, Jovanova, O, Uitterlinden, A G, Hofman, A, Janssen, H L A, Murad, S Darwish, Kraaij, R, Stedehouder, J, van den Hout, M C G N, Kros, J M, van IJcken, W F J, Tiemeier, H, Kushner, S A, van Duijn, C M

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An interaction network of mental disorder proteins in neural stem cells by Moen, M J, Adams, H H H, Brandsma, J H, Dekkers, D H W, Akinci, U, Karkampouna, S, Quevedo, M, Kockx, C E M, Ozgür, Z, van IJcken, W F J, Demmers, J, Poot, R A

“…Mental disorders (MDs) such as intellectual disability (ID), autism spectrum disorders (ASD) and schizophrenia have a strong genetic component. Recently, many…”
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Germline variant in MSX1 identified in a Dutch family with clustering of Barrett’s esophagus and esophageal adenocarcinoma by van Nistelrooij, A. M. J., van Marion, R., van Ijcken, W. F. J., de Klein, A., Wagner, A., Biermann, K., Spaander, M. C. W., van Lanschot, J. J. B., Dinjens, W. N. M., Wijnhoven, B. P. L.

“…The vast majority of esophageal adenocarcinoma cases are sporadic and caused by somatic mutations. However, over the last decades several families have been…”
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CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer by van Agthoven, T, Sieuwerts, A M, Veldscholte, J, Meijer-van Gelder, M E, Smid, M, Brinkman, A, den Dekker, A T, Leroy, I M, van IJcken, W F J, Sleijfer, S, Foekens, J A, Dorssers, L C J

“…Background: Endocrine therapies of breast cancer are effective but ultimately fail because of the development of treatment resistance. We have previously…”
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Pandemic 2009 H1N1 Influenza Virus Causes Diffuse Alveolar Damage in Cynomolgus Macaques by Herfst, S., van den Brand, J. M. A., Schrauwen, E. J. A., de Wit, E., Munster, V. J., van Amerongen, G., Linster, M., Zaaraoui, F., van Ijcken, W. F. J., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., Fouchier, R. A. M., Andeweg, A. C., Kuiken, T.

“…The pathogenesis of lower respiratory tract disease from the pandemic 2009 H1N1 (H1N1v) influenza A virus is poorly understood. Therefore, either H1N1v virus…”
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