Search Results - "van Hinsbergh, Victor W.M."

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin by Juni, Rio P., PhD, Kuster, Diederik W.D., PhD, Goebel, Max, MSc, Helmes, Michiel, PhD, Musters, René J.P., PhD, van der Velden, Jolanda, PhD, Koolwijk, Pieter, PhD, Paulus, Walter J., MD, PhD, van Hinsbergh, Victor W.M., PhD

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Endothelial Progenitors: A Consensus Statement on Nomenclature by Medina, Reinhold J., Barber, Chad L., Sabatier, Florence, Dignat‐George, Francoise, Melero‐Martin, Juan M., Khosrotehrani, Kiarash, Ohneda, Osamu, Randi, Anna M., Chan, Jerry K.Y., Yamaguchi, Teruhide, Van Hinsbergh, Victor W.M., Yoder, Mervin C., Stitt, Alan W.

“…Summary Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct…”
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Pericellular Proteases in Angiogenesis and Vasculogenesis by van Hinsbergh, Victor W.M, Engelse, Marten A, Quax, Paul H.A

“…Pericellular proteases play an important role in angiogenesis and vasculogenesis. They comprise (membrane-type) matrix metalloproteinases [(MT-)MMPs], serine…”
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Traction force dynamics predict gap formation in activated endothelium by Valent, Erik T., van Nieuw Amerongen, Geerten P., van Hinsbergh, Victor W.M., Hordijk, Peter L.

“…In many pathological conditions the endothelium becomes activated and dysfunctional, resulting in hyperpermeability and plasma leakage. No specific therapies…”
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Involvement of RhoA/Rho Kinase Signaling in VEGF-Induced Endothelial Cell Migration and Angiogenesis In Vitro by van Nieuw Amerongen, Geerten P, Koolwijk, Pieter, Versteilen, Amanda, van Hinsbergh, Victor W.M

“…OBJECTIVE—Growth factor-induced angiogenesis involves migration of endothelial cells (ECs) into perivascular areas and requires active remodeling of the…”
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ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension by Beckers, Cora M.L, Knezevic, Nebojsa, Valent, Erik T, Tauseef, Mohammad, Krishnan, Ramaswamy, Rajendran, Kavitha, Hardin, C. Corey, Aman, Jurjan, van Bezu, Jan, Sweetnam, Paul, van Hinsbergh, Victor W.M, Mehta, Dolly, van Nieuw Amerongen, Geerten P

“…Abstract Rho kinase mediates the effects of inflammatory permeability factors by increasing actomyosin-generated traction forces on endothelial adherens…”
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Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries by BAKKER, Wineke, SIPKEMA, Pieter, STEHOUWER, Coen D. A, SERNE, Erik H, SMULDERS, Yvo M, VAN HINSBERGH, Victor W. M, ERINGA, Etto C

“…Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries Wineke Bakker 1 , Pieter Sipkema 1 , Coen D.A. Stehouwer 2 ,…”
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Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability by Kupreishvili, Koba, MD, Fuijkschot, Wessel W., MD, Vonk, Alexander B.A., MD, PhD, Smulders, Yvo M., MD, PhD, Stooker, Wim, MD, PhD, Van Hinsbergh, Victor W.M., MD, PhD, Niessen, Hans W.M., MD, PhD, Krijnen, Paul A.J., PhD

“…Abstract Objectives Mast cells (MCs) may play an important role in plaque destabilization and atherosclerotic coronary complications. Here, we have studied the…”
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Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System by van Nieuw Amerongen, Geerten P, van Hinsbergh, Victor W.M

“…Abstract —Rho-like small GTPases, with their main representatives (Rho, Rac, and Cdc42), have been recognized in the past decade as key regulators of the…”
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Hypercholesterolemia Reduces Collateral Artery Growth More Dominantly Than Hyperglycemia or Insulin Resistance in Mice by van Weel, Vincent, de Vries, Margreet, Voshol, Peter J, Verloop, Robert E, Eilers, Paul H.C, van Hinsbergh, Victor W.M, van Bockel, J Hajo, Quax, Paul H.A

“…OBJECTIVE—Collateral artery development (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease, may be deregulated by…”
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Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells by Uthman, Laween, Homayr, Anna, Juni, Rio P, Spin, Eva L, Kerindongo, Raphaela, Boomsma, Marleen, Hollmann, Markus W, Preckel, Benedikt, Koolwijk, Pieter, van Hinsbergh, Victor W M, Zuurbier, Coert J, Albrecht, Martin, Weber, Nina C

“…Heart failure is characterized by chronic low-grade vascular inflammation, which in itself can lead to endothelial dysfunction. Clinical trials showed…”
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Vascular Endothelial Growth Factor Overexpression in Ischemic Skeletal Muscle Enhances Myoglobin Expression In Vivo by van Weel, Vincent, Deckers, Martine M.L, Grimbergen, Jos M, van Leuven, Kees J.M, Lardenoye, JanWillem H.P, Schlingemann, Reinier O, van Nieuw Amerongen, Geerten P, van Bockel, J Hajo, van Hinsbergh, Victor W.M, Quax, Paul H.A

“…Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease…”
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Thin-Walled Microvessels in Human Coronary Atherosclerotic Plaques Show Incomplete Endothelial Junctions : Relevance of Compromised Structural Integrity for Intraplaque Microvascular Leakage by SLUIMER, Judith C, KOLODGIE, Frank D, DAEMEN, Mat J. A. P, BIJNENS, Ann P. J. J, MAXFIELD, Kimberly, PACHECO, Erica, KUTYS, Bob, DUIMEL, Hans, FREDERIK, Peter M, VAN HINSBERGH, Victor W. M, VIRMANI, Renu

“…This study sought to examine the ultrastructure of microvessels in normal and atherosclerotic coronary arteries and its association with plaque phenotype…”
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Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue by Eringa, Etto C, Bakker, Wineke, van Hinsbergh, Victor W.M

“…Abstract A small amount of adipose tissue associated with small arteries and arterioles is encountered both in mice and man. This perivascular adipose tissue…”
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Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice by Meijer, Rick I, Bakker, Wineke, Alta, Caro-Lynn A F, Sipkema, Pieter, Yudkin, John S, Viollet, Benoit, Richter, Erik A, Smulders, Yvo M, van Hinsbergh, Victor W M, Serné, Erik H, Eringa, Etto C

“…Microvascular recruitment in muscle is a determinant of insulin sensitivity. Whether perivascular adipose tissue (PVAT) is involved in disturbed…”
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Thin-Walled Microvessels in Human Coronary Atherosclerotic Plaques Show Incomplete Endothelial Junctions by Sluimer, Judith C., PhD, Kolodgie, Frank D., PhD, Bijnens, Ann P.J.J., PhD, Maxfield, Kimberly, BSc, Pacheco, Erica, MSc, Kutys, Bob, MSc, Duimel, Hans, BSc, Frederik, Peter M., PhD, van Hinsbergh, Victor W.M., PhD, Virmani, Renu, MD, PhD, Daemen, Mat J.A.P., MD, PhD

“…Objectives This study sought to examine the ultrastructure of microvessels in normal and atherosclerotic coronary arteries and its association with plaque…”
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Role of Fibrin Matrix in Angiogenesis by van HINSBERGH, VICTOR W.M., COLLEN, ANNEMIE, KOOLWIJK, PIETER

“…: Angiogenesis, the formation of new blood vessels from existing vessels, plays an important role during development. In the adult, it is limited to the female…”
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Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2 by de Boer, Michiel P, Meijer, Rick I, Richter, Erik A, van Nieuw Amerongen, Geerten P, Sipkema, Pieter, van Poelgeest, Erik M, Aman, Jurjan, Kokhuis, Tom J.A, Koolwijk, Pieter, van Hinsbergh, Victor W.M, Smulders, Yvo M, Serné, Erik H, Eringa, Etto C

“…Abstract Decreased tissue perfusion increases the risk of developing insulin resistance and cardiovascular disease in obesity, and decreased levels of globular…”
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Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton by Bijman, Marcel N A, van Nieuw Amerongen, Geerten P, Laurens, Nancy, van Hinsbergh, Victor W M, Boven, Epie

“…Conventional anticancer agents may display antiangiogenic effects, but the underlying mechanism is poorly understood. We determined the antiangiogenic…”
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Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin by Draijer, Richard, Vaandrager, Arie B, Nolte, Christine, de Jonge, Hugo R, Walter, Ulrich, van Hinsbergh, Victor W.M

“…Previous studies demonstrated that the thrombin-induced permeability of endothelial cell monolayers is reduced by the elevation of cGMP. In the present study,…”
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