Search Results - "van Hinsbergh, V. W. M."

Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients by van der Heijden, M, van Nieuw Amerongen, G P, Koolwijk, P, van Hinsbergh, V W M, Groeneveld, A B J

“…Angiopoietin-2 and vascular endothelial growth factor (VEGF) may impair vascular barrier function while angiopoietin-1 may protect it. It was hypothesised that…”
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A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity by Amado-Azevedo, J., Reinhard, N. R., van Bezu, J., de Menezes, R. X., van Beusechem, V. W., van Nieuw Amerongen, G. P., van Hinsbergh, V. W. M., Hordijk, P. L.

“…Endothelial barrier function is carefully controlled to protect tissues from edema and damage inflicted by extravasated leukocytes. RhoGTPases, in conjunction…”
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Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis by van Nieuw Amerongen, G P, Musters, R J P, Eringa, E C, Sipkema, P, van Hinsbergh, V W M

“…Endothelial hyperpermeability is regulated by a myosin light chain-2 (MLC2) phosphorylation-dependent contractile mechanism. Thrombin is a potent inducer of…”
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Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function by Boa, B C S, Yudkin, J S, Hinsbergh, V W M, Bouskela, E, Eringa, E C

“…Obesity is a global epidemic, accompanied by increased risk of type 2 diabetes and cardiovascular disease. Adipose tissue hypertrophy is associated with…”
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Pulmonary embolism causes endomyocarditis in the human heart by Begieneman, M P V, van de Goot, F R W, van der Bilt, I A C, Vonk Noordegraaf, A, Spreeuwenberg, M D, Paulus, W J, van Hinsbergh, V W M, Visser, F C, Niessen, H W M

“…Pulmonary embolism (PE) is a significant cause of morbidity and mortality. In a recent study in patients with PE, an increased level of macrophages was found…”
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Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications by Naaijkens, B. A, Niessen, H. W. M, Prins, H-J, Krijnen, P. A. J, Kokhuis, T. J. A, de Jong, N, van Hinsbergh, V. W. M, Kamp, O, Helder, M. N, Musters, R. J. P, van Dijk, A, Juffermans, L. J. M

“…Adipose-derived stromal cells (ASC) are promising candidates for cell therapy, for example to treat myocardial infarction. Commonly, fetal bovine serum (FBS)…”
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Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil by MOUCHAERS, K. T. B, SCHALIJ, I, DE BOER, M. A, POSTMUS, P. E, VAN HINSBERGH, V. W. M, VAN NIEUW AMERONGEN, G. P, VONK NOORDEGRAAF, A, VAN DER LAARSE, W. J

“…Pulmonary arterial hypertension (PAH) still cannot be cured, warranting the search for novel treatments. Fasudil (a Rho kinase inhibitor) was compared with…”
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Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions by Plaisier, M., Dennert, I., Rost, E., Koolwijk, P., van Hinsbergh, V.W.M., Helmerhorst, F.M.

“…BACKGROUND Decidual vascular development is important for implantation. This study analysed decidual vascular adaptation to implantation in correlation with…”
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Involvement of Rho Kinase in Endothelial Barrier Maintenance by van Nieuw Amerongen, G P, Beckers, C M.L, Achekar, I D, Zeeman, S, Musters, R J.P, van Hinsbergh, V W.M

“…OBJECTIVE—Rho kinase mediates vascular leakage caused by many vasoactive agents including thrombin. Enhanced Rho kinase activity induces endothelial barrier…”
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Angiotensin converting enzyme inhibiting therapy is associated with lower vitreous vascular endothelial growth factor concentrations in patients with proliferative diabetic retinopathy by HOGEHOOM VAN BUGGENUM, I. M, POLAK, B. C. P, REICHERT-THOEN, J. W. M, DE VRIES-KNOPPERT, W. A. E. J, VAN HINSBERGH, V. W. M, TANGELDER, G. J

“…Vascular endothelial growth factor (VEGF) is thought to be instrumental in the progression of diabetic retinopathy. Indications exist that the…”
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Natural Killer Cells and CD4+ T-Cells Modulate Collateral Artery Development by van Weel, V, Toes, R E.M, Seghers, L, Deckers, M M.L, de Vries, M R, Eilers, P H, Sipkens, J, Schepers, A, Eefting, D, van Hinsbergh, V W.M, van Bockel, J H, Quax, P H.A

“…OBJECTIVE—The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients…”
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Accelerated Atherosclerosis by Placement of a Perivascular Cuff and a Cholesterol-Rich Diet in ApoE3Leiden Transgenic Mice by Lardenoye, J H. P, Delsing, D J. M, de Vries, M R, Deckers, M M. L, Princen, H M. G, Havekes, L M, van Hinsbergh, V W. M, van Bockel, J H, Quax, P H. A

“…Intimal hyperplasia after vascular injury is usually studied in animal models with healthy, normocholesterolemic animals. Here, we assess the effect of…”
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Impact of Apolipoprotein(a) on In Vitro Angiogenesis by Schulter, V, Koolwijk, P, Peters, E, Frank, S, Hrzenjak, A, Graier, W F, M. van Hinsbergh, V W, Kostner, G M

“…Abstract —Angiostatin, which consists of the kringle I–IV domains of plasminogen and which is secreted into urine, is an efficient inhibitor of angiogenesis…”
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Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality? by Becker, A., Van Hinsbergh, V. W. M., Jager, A., Kostense, P. J., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., Stehouwer, C. D. A.

“…Increased plasma levels of soluble adhesion molecules are associated with an increased risk of atherothrombosis. The pathophysiological mechanisms responsible…”
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Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction : evidence for chronic inflammation by SCHALKWIJK, C. G, POLAND, D. C. W, VAN DIJK, W, KOK, A, EMEIS, J. J, DRÄGER, A. M, DONI, A, VAN HINSBERGH, V. W. M, STEHOUWER, C. D. A

“…Moderately increased plasma concentrations of C-reactive protein are associated with an increased risk of cardiovascular disease. C-reactive protein, its…”
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Endothelial insulin receptor expression in human atherosclerotic plaques: Linking micro- and macrovascular disease in diabetes? by Rensing, K.L, von der Thüsen, J.H, Weijers, E.M, Houttuijn Bloemendaal, F.M, van Lammeren, G.W, Vink, A, van der Wal, A.C, van Hinsbergh, V.W.M, van der Loos, C.M, Stroes, E.S, Koolwijk, P, Twickler, Th.B

“…Highlights ► Insulin enhances capillary-like tube formation of human microvascular endothelial cells. ► Insulin receptors are highly expressed on endothelial…”
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In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI by LAMFERS, M. L. M, LARDENOYE, J. H. P, DE VRIES, M. R, AALDERS, M. C, ENGELSE, M. A, GRIMBERGEN, J. M, VAN HINSBERGH, V. W. M, QUAX, P. H. A

“…Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled…”
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Angiogenic growth factors and their receptors in first-trimester human decidua of pregnancies further complicated by preeclampsia or fetal growth restriction by Plaisier, M, Streefland, E, Koolwijk, P, van Hinsbergh, V W M, Helmerhorst, F M, Erwich, J J H M

“…Disturbances in decidual and placental vascular development may play a role in the pathogenesis of pregnancy complications. This study focused on the role of…”
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Effect of prior statin therapy on capillary permeability in the lungs after cardiac or vascular surgery by van de Visse, E. P, van der Heijden, M, Verheij, J, van Nieuw Amerongen, G. P, van Hinsbergh, V. W. M, Girbes, A. R. J, Groeneveld, A. B. J

“…Cholesterol-lowering statins can ameliorate severe forms of vascular hyperpermeability in experimental studies, and may thereby ameliorate acute lung injury…”
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The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity by Amado-Azevedo, J., Reinhard, N.R., van Bezu, J., van Nieuw Amerongen, G.P., van Hinsbergh, V.W.M., Hordijk, P.L.

“…Endothelial cells line the vasculature and act as gatekeepers that control the passage of plasma, macromolecules and cells from the circulation to the…”
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