Use and Waste of Reconstituted Whole Blood Exchange Transfusions: An 11-year National Observational Study

To identify indications for exchange transfusions, assess the use and waste of exchange transfusion products (ie, reconstituted whole blood exchange transfusions), and determine nationwide distribution and prevalence of these transfusions in the Netherlands. All 9 neonatal intensive care units and 1...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of pediatrics Vol. 275; p. 114225
Main Authors:	de Winter, Derek P., Lopriore, Enrico, Hulzebos, Christian V., Lukens, Michaël V., Klinkspoor, J.H. (Harriët), van Bohemen, Michaela, den Besten, Gijs, de Vooght, Karen M.K., Vrancken, Sabine L.A.G., Trompenaars, Amanda M.P., Hoffmann-Haringsma, Angelique, Péquériaux, N.C.V. (Nathalie), Andriessen, Peter, Gijzen, Karlijn, van Hillegersberg, J.L.A.M. (Jacqueline), Zant, Janneke C., van Rossem, Maaike C., van Gammeren, A.J. Adriaan, Weerkamp, Floor, Counsilman, Clare E., Knol, F.R. (Rachel), Schiering, I.A.M. (Irene), Dubbink-Verheij, Gerdina H., Verweij, E.J.T. (Joanne), de Haas, Masja
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2024
Subjects:	Exchange transfusion hyperbilirubinemia pertussis prevalence Exchange transfusion prevalence NICU pertussis hyperbilirubinemia Pertussis Hyperbilirubinemia Prevalence
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To identify indications for exchange transfusions, assess the use and waste of exchange transfusion products (ie, reconstituted whole blood exchange transfusions), and determine nationwide distribution and prevalence of these transfusions in the Netherlands. All 9 neonatal intensive care units and 15 non-neonatal intensive care unit hospitals participated in this retrospective, observational, cohort study. We retrieved data on the indications for and use of all exchange transfusion products ordered by participating centers over an 11-year period. A total of 574 patients for whom 1265 products were ordered were included for analyses. Severe ABO (32.6%) and non-ABO (25.2%) immune hemolysis and subsequent hyperbilirubinemia were the most frequent indications. Rare indications were severe leukocytosis in Bordetella pertussis (2.1%) and severe anemia (1.5%). Approximately one-half of all ordered products remained unused. In 278 of 574 neonates (48.4%), ≥1 products were not used, of which 229 (82.7%) were due to the resolving of severe hyperbilirubinemia with further intensification of phototherapy. The overall prevalence of neonates who received an exchange transfusion was 14.6:100 000 liveborn neonates. A considerable proportion of products remained unused, and annually a limited number of patients are treated with an exchange transfusion in the Netherlands, highlighting the rarity of the procedure in the Netherlands.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0022-3476 1097-6833 1097-6833
DOI:	10.1016/j.jpeds.2024.114225