Search Results - "van Heertum, Ronald L."

Effect of a Triallelic Functional Polymorphism of the Serotonin-Transporter-Linked Promoter Region on Expression of Serotonin Transporter in the Human Brain by Parsey, Ramin V., Hastings, Ramin S., Oquendo, Maria A., Hu, Xianzhang, Goldman, David, Huang, Yung-yu, Simpson, Norman, Arcement, Julie, Huang, Yiyun, Ogden, R. Todd, Van Heertum, Ronald L., Arango, Victoria, Mann, J. John

“…OBJECTIVE: The authors examined effects of a triallelic functional polymorphism of the human serotonin-transporter-linked promoter region (5-HTTLPR) on in vivo…”
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Epilepsy duration impacts on brain glucose metabolism in temporal lobe epilepsy: Results of voxel-based mapping by Akman, Cigdem I, Ichise, Masonori, Olsavsky, Aviva, Tikofsky, Ronald S, Heertum, Ronald L. Van, Gilliam, Frank

“…Abstract Objective [18 F]Fluorodeoxyglucose positron emission tomography ([18 F]FDG-PET) is a valuable method for detecting focal brain dysfunction associated…”
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Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia by Kegeles, Lawrence S, Abi-Dargham, Anissa, Zea-Ponce, Yolanda, Rodenhiser-Hill, Janine, Mann, J.John, Van Heertum, Ronald L, Cooper, Thomas B, Carlsson, Arvid, Laruelle, Marc

“…Background: Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum…”
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Imaging the metabolic footprint of Glut1 deficiency on the brain by Pascual, Juan M., van Heertum, Ronald L., Wang, Dong, Engelstad, Kristin, De Vivo, Darryl C.

“…Cerebral 18F‐fluorodeoxyglucose positron emission tomography in 14 patients with microcephaly, developmental delay, seizures, and mutations of the glucose…”
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Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety by SULLIVAN, Gregory M, OQUENDO, Maria A, SIMPSON, Norman, VAN HEERTUM, Ronald L, MANN, J. John, PARSEY, Ramin V

“…The anxious phenotype of the 5-HT1A receptor knockout mouse and the anxiolytic properties of 5-HT1A agonists suggest that the 5-HT1A receptor modulates…”
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Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates by Kumar, J S Dileep, Prabhakaran, Jaya, Majo, Vattoly J, Milak, Matthew S, Hsiung, Shu-Chi, Tamir, Hadassah, Simpson, Norman R, Van Heertum, Ronald L, Mann, J John, Parsey, Ramin V

“…Serotonin1A (5-HT1A) receptors exist in high- and low-affinity states, and agonist ligands bind preferentially to the high-affinity state of the receptor and…”
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A general method for the synthesis of aryl [ 11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression by Majo, Vattoly J., Prabhakaran, Jaya, Simpson, Norman R., Van Heertum, Ronald L., Mann, J. John, Dileep Kumar, J.S.

“…A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled…”
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Interventional Nuclear Brain Imaging by Leung, David K., MD, PhD, Van Heertum, Ronald L., MD

“…Interventional nuclear brain imaging incorporates a variety of radiopharmaceutical techniques to enhance the functional assessment of the central nervous…”
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Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials by Van Heertum, Ronald L, Scarimbolo, Robert, Wolodzko, John G, Klencke, Barbara, Messmann, Richard, Tunc, Feza, Sokol, Levi, Agarwal, Rajan, Strafaci, James A, O'Neal, Michael

“…An operationalized workflow paradigm is presented and validated with pilot subject data. This approach is reproducible with a high concordance rate between…”
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NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans by Kegeles, Lawrence S., Martinez, Diana, Kochan, Lisa D., Hwang, Dah-Ren, Huang, Yiyun, Mawlawi, Osama, Suckow, R. F., Van Heertum, Ronald L., Laruelle, Marc

“…Previous brain imaging studies with [11C]raclopride have suggested that the psychotogenic effects of the noncompetitive N‐methyl‐D‐aspartate antagonist…”
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Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors by DILEEP KUMAR, J. S, MAJO, Vattoly J, SULLIVAN, Gregory M, PRABHAKARAN, Jaya, SIMPSON, Norman R, VAN HEERTUM, Ronald L, MANN, J. John, PARSEY, Ramin V

“…Synthesis and evaluation of [O-methyl-11C](4-methoxy-2-methylphenyl)[1-(1-methoxymethylpropyl)-6-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-4-yl]amine or…”
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Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study by Parsey, Ramin V., Oquendo, Maria A., Ogden, R. Todd, Olvet, Doreen M., Simpson, Norman, Huang, Yung-yu, Van Heertum, Ronald L., Arango, Victoria, Mann, J. John

“…Serotonin 1A receptors (5-HT 1A) are implicated in the pathophysiology of major depressive disorder (MDD) and in the action of selective serotonin reuptake…”
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Synthesis of [11C]celecoxib: a potential PET probe for imaging COX-2 expression by Prabhakaran, Jaya, Majo, Vattoly J., Simpson, Norman R., Van Heertum, Ronald L., Mann, J. John, Kumar, J. S. Dileep

“…[11C]Labeling of celecoxib, a COX‐2 selective inhibitor and prescription drug for arthritis and pain has been achieved. The precursor molecule for the…”
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F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis by Provenzano, Frank Anthony, Jordan, Barry, Tikofsky, Ronald S, Saxena, Chitra, Van Heertum, Ronald L, Ichise, Masanori

“…PURPOSEThe participation in concussive susceptible sports such as boxing may cause chronic traumatic brain injury. The objective of this study was to determine…”
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In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter by Severance, Alin J, Milak, Matthew S, Kumar, J S Dileep, Prabhakaran, Jaya, Majo, Vattoly J, Simpson, Norman R, Van Heertum, Ronald L, Arango, Victoria, Mann, J John, Parsey, Ramin V

“…Antagonism of norepinephrine reuptake is now an important pharmacological strategy in the treatment of anxiety and depressive disorders, and many…”
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Increased baseline occupancy of D2 receptors by dopamine in schizophrenia by Abi-Dargham, A, Rodenhiser, J, Printz, D, Zea-Ponce, Y, Gil, R, Kegeles, L S, Weiss, R, Cooper, T B, Mann, J J, Van Heertum, R L, Gorman, J M, Laruelle, M

“…The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of dopaminergic transmission at the D 2 receptor. We measured in vivo occupancy…”
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Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptors by Kumar, J S Dileep, Prabhakaran, Jaya, Arango, Victoria, Parsey, Ramin V, Underwood, Mark D, Simpson, Norman R, Kassir, Suham A, Majo, Vattoly J, Van Heertum, Ronald L, Mann, J John

“…Synthesis and in vitro evaluation of [O-methyl-(11)C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide…”
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Regional Heterogeneity of 5-HT1A Receptors in Human Cerebellum as Assessed by Positron Emission Tomography by Parsey, Ramin V, Arango, Victoria, Olvet, Doreen M, Oquendo, Maria A, Van Heertum, Ronald L, Mann, J John

“…Two measures used in brain imaging are binding potential (BP) and the specific to nonspecific equilibrium partition coefficient (V3“). V3” determined using the…”
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Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials by Van Heertum, Ronald L, Scarimbolo, Robert, Ford, Robert, Berdougo, Eli, O'Neal, Michael

“…In the era of personalized medicine, diagnostic approaches are helping pharmaceutical and biotechnology sponsors streamline the clinical trial process…”
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Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects by Scarmeas, Nikolaos, Zarahn, Eric, Anderson, Karen E, Hilton, John, Flynn, Joseph, Van Heertum, Ronald L, Sackeim, Harold A, Stern, Yaakov

“…Cognitive reserve (CR) is the ability of an individual to cope with advancing brain pathology so that he remains free of symptomatology. Epidemiological…”
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