Search Results - "van Heemst, Diana"

Natriuretic peptides in the central nervous system: Novel targets for cognitive impairment by Mahinrad, Simin, de Craen, Anton J M, Yasar, Sevil, van Heemst, Diana, Sabayan, Behnam

“…Natriuretic peptides (NPs) are traditionally known as cardiac hormones with diuretic, natriuretic and blood pressure lowering properties. Evidence indicates…”
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Comparing Methods for Measurement Error Detection in Serial 24-h Hormonal Data by van der Spoel, Evie, Choi, Jungyeon, Roelfsema, Ferdinand, Cessie, Saskia le, van Heemst, Diana, Dekkers, Olaf M.

“…Measurement errors commonly occur in 24-h hormonal data and may affect the outcomes of such studies. Measurement errors often appear as outliers in such data…”
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Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion by Opstal, Anna M. van, Akintola, Abimbola A., Elst, Marjan van der, Westendorp, Rudi G., Pijl, Hanno, Heemst, Diana van, Grond, Jeroen van der

“…The hypothalamus is a crucial structure in the brain that responds to metabolic cues and regulates energy homeostasis. Patients with type 2 diabetes…”
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Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults by Roelfsema, Ferdinand, van Heemst, Diana, Iranmanesh, Ali, Takahashi, Paul, Yang, Rebecca, Veldhuis, Johannes D

“…Context Studies on 24-h cortisol secretion are rare. The impact of sex, age and adiposity on cortisol levels, often restricted to one or a few samples, are…”
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Mental Performance in Old Age Dependent on Cortisol and Genetic Variance in the Mineralocorticoid and Glucocorticoid Receptors by KUNINGAS, Maris, DE RIJK, Roel H, WESTENDORP, Rudi G. J, JOLLES, Jelle, SLAGBOOM, P. Eline, HEEMST, Diana Van

“…Depression and cognitive decline have been associated with changes in circulating cortisol concentrations. Cortisol exerts its functions through…”
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Lifestyle‐Intervention‐Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter by Beekman, Marian, Schutte, Bianca A.M., Akker, Erik B. van den, Noordam, Raymond, Dibbets‐Schneider, Petra, Geus‐Oei, Lioe‐Fee, Deelen, Joris, Rest, Ondine van de, Heemst, Diana van, Feskens, Edith J.M., Slagboom, P. Eline

“…Scope Abdominal obesity is one of the main modifiable risk factors of age‐related cardiometabolic disease. Cardiometabolic disease risk and its associated high…”
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High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes by Noordam, Raymond, Huurman, Neline C, Wijsman, Carolien A, Akintola, Abimbola A, Jansen, Steffy W M, Stassen, Stephanie, Beekman, Marian, van de Rest, Ondine, Slagboom, P Eline, Mooijaart, Simon P, van Heemst, Diana

“…It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the…”
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ApoE plasma levels and risk of cardiovascular mortality in old age by Mooijaart, Simon P, Berbée, Jimmy F P, van Heemst, Diana, Havekes, Louis M, de Craen, Anton J M, Slagboom, P Eline, Rensen, Patrick C N, Westendorp, Rudi G J

“…The epsilon2, epsilon3, and epsilon4 alleles of the apolipoprotein E gene (APOE) encode three isoforms, apoE2, E3, and E4, respectively. The apoE isoforms…”
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Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction by Victorelli, Stella, Lagnado, Anthony, Halim, Jessica, Moore, Will, Talbot, Duncan, Barrett, Karen, Chapman, James, Birch, Jodie, Ogrodnik, Mikolaj, Meves, Alexander, Pawlikowski, Jeff S, Jurk, Diana, Adams, Peter D, van Heemst, Diana, Beekman, Marian, Slagboom, P Eline, Gunn, David A, Passos, João F

“…Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that…”
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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals by Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
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Different types of V(D)J recombination and end‐joining defects in DNA double‐strand break repair mutant mammalian cells by Verkaik, Nicole S., Esveldt‐van Lange, Rebecca E. E., Heemst, Diana van, Brüggenwirth, Hennie T., Hoeijmakers, Jan H. J., Zdzienicka, Malgorzata Z., Gent, Dik C. van

“…The end‐joining pathway of DNA double‐strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation…”
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Association of a composite trait for anthropometrics, adiposity and energy expenditure with cardiometabolic diseases: An age‐stratified cohort and genetic risk score analysis by Meulmeester, Fleur L., Dijk, Ko Willems, Heemst, Diana, Noordam, Raymond

“…Aim Various anthropometric measures capture distinct as well as overlapping characteristics of an individual's body composition. To characterize independent…”
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The impact of sociodemographic status on the association of classical cardiovascular risk factors with coronary artery disease: a stratified Mendelian randomization study by Martens, Leon G., van Hamersveld, Daan, le Cessie, Saskia, Willems van Dijk, Ko, van Heemst, Diana, Noordam, Raymond

“…Low socioeconomic status (SES) is associated with cardiovascular risk factors and increased coronary artery disease (CAD) risk. We tested whether SES is an…”
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Within-Person Variation in Serum Thyrotropin Concentrations: Main Sources, Potential Underlying Biological Mechanisms, and Clinical Implications by van der Spoel, Evie, Roelfsema, Ferdinand, van Heemst, Diana

“…Individuals exhibit fluctuations in the concentration of serum thyroid-stimulating hormone (TSH) over time. The scale of these variations ranges from minutes…”
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Thyroid Signaling, Insulin Resistance, and 2 Diabetes Mellitus: A Mendelian Randomization Study by Bos, Maxime M, Smit, Roelof A J, Trompet, Stella, van Heemst, Diana, Noordam, Raymond

“…Increasing evidence suggests an association between thyroid-stimulating hormone (TSH), free thyroxine (fT4), and deiodinases with insulin resistance and type 2…”
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Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease by Surowiec, Izabella, Noordam, Raymond, Bennett, Kate, Beekman, Marian, Slagboom, P. Eline, Lundstedt, Torbjörn, van Heemst, Diana

“…Background We aimed to identify novel metabolite and lipid signatures connected with the metabolic syndrome in a Dutch middle-aged population. Methods 115…”
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Functional Changes of T-Cell Subsets with Age and CMV Infection by Hassouneh, Fakhri, Goldeck, David, Pera, Alejandra, van Heemst, Diana, Slagboom, P. Eline, Pawelec, Graham, Solana, Rafael

“…Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that…”
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Genetically Determined Higher TSH Is Associated With a Lower Risk of Diabetes Mellitus in Individuals With Low BMI by Bos, Maxime M, van Vliet, Nicolien A, Mooijaart, Simon P, Noordam, Raymond, van Heemst, Diana

“…Abstract Context Thyroid status is hypothesized to be causally related with the risk of diabetes mellitus (DM), but previous results were conflicting possibly…”
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Marked heterogeneity in growth characteristics of myoblast clonal cultures and myoblast mixed cultures obtained from the same individual by Maier, Andrea B, Cohen, Ron, Blom, Joke, van Heemst, Diana, Westendorp, Rudi G J

“…Sarcopenia is defined as an age-related decrease in skeletal muscle mass and function while adjacent satellite cells are unable to compensate for this loss…”
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No evidence linking sleep traits with white blood cell counts: Multivariable‐adjusted and Mendelian randomization analyses by Noordam, Raymond, Ao, Linjun, Stroo, Jasmijn F., Willems van Dijk, Ko, Heemst, Diana

“…Background Disturbances in habitual sleep have been associated with multiple age‐associated diseases. However, the biological mechanisms underpinning these…”
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