Epithelial cells in bone marrow: do they matter?

Patients with breast cancer frequently develop clinically manifest bone marrow metastases and in these patients detection of this type of micrometastatic disease has been shown to have prognostic impact. 1, 2 Gastrointestinal cancers, however, relatively rarely develop overt bone marrow metastases a...

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Bibliographic Details
Published in:	Gut Vol. 54; no. 12; pp. 1821 - 1822
Main Authors:	Marsman, W A, Westerterp, M, van Heek, N J, ten Kate, F J, Izbicki, J R, van Lanschot, J J B
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01-12-2005 BMJ Publishing Group LTD Copyright 2005 by Gut
Subjects:	Adenocarcinoma - secondary Adenoma - pathology Bone marrow Bone Marrow Cells - pathology Bone Marrow Neoplasms - secondary Cancer colorectal adenoma epithelial cells Epithelial Cells - pathology Esophageal Neoplasms - pathology Humans Letter Metastasis Morphology Phosphatase Tumors Germany
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Summary:	Patients with breast cancer frequently develop clinically manifest bone marrow metastases and in these patients detection of this type of micrometastatic disease has been shown to have prognostic impact. 1, 2 Gastrointestinal cancers, however, relatively rarely develop overt bone marrow metastases and also the clinical impact of the detection of bone marrow micrometastases in these patients is less clear. Studies that have examined negative control patients have also reported positive bone marrow staining for Ber-EP4 cells in up to 10% of patients. 3, 4 One study focused on the methodology of the alkaline phosphatase-antialkaline phosphatase staining and reported positive staining in up to 42% of patients without cancer.
Bibliography:	ark:/67375/NVC-X04TC2DC-5 local:0541821a Correspondence to:  Dr W A Marsman  Department of Gastroenterology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; w.a.marsman@amc.uva.nl istex:65E058B59DDC13F43F0FEAEBD120FBEE8D3D703B href:gutjnl-54-1821-2.pdf PMID:16284299 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2 Conflict of interest: None declared. Correspondence to: Dr W A Marsman Department of Gastroenterology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; w.a.marsman@amc.uva.nl
ISSN:	0017-5749 1468-3288 1458-3288
DOI:	10.1136/gut.2005.078774