Search Results - "van Heck, Ruben G. A"
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More than just a gut feeling: constraint-based genome-scale metabolic models for predicting functions of human intestinal microbes
Published in Microbiome (14-07-2017)“…The human gut is colonized with a myriad of microbes, with substantial interpersonal variation. This complex ecosystem is an integral part of the…”
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The revisited genome of Pseudomonas putida KT2440 enlightens its value as a robust metabolic chassis
Published in Environmental microbiology (01-10-2016)“…Summary By the time the complete genome sequence of the soil bacterium Pseudomonas putida KT2440 was published in 2002 (Nelson et al., ) this bacterium was…”
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Green genes: bioinformatics and systems-biology innovations drive algal biotechnology
Published in Trends in biotechnology (Regular ed.) (01-12-2014)“…Highlights • Microalgae are potential hosts for industrial biosynthesis of valuable compounds. • Genome sequences of many microalgae are available, but…”
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Efficient Reconstruction of Predictive Consensus Metabolic Network Models
Published in PLoS computational biology (01-08-2016)“…Understanding cellular function requires accurate, comprehensive representations of metabolism. Genome-scale, constraint-based metabolic models (GSMs) provide…”
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In silico-guided engineering of Pseudomonas putida towards growth under micro-oxic conditions
Published in Microbial cell factories (22-10-2019)“…Pseudomonas putida is a metabolically versatile, genetically accessible, and stress-robust species with outstanding potential to be used as a workhorse for…”
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Consistency, Inconsistency, and Ambiguity of Metabolite Names in Biochemical Databases Used for Genome-Scale Metabolic Modelling
Published in Metabolites (06-02-2019)“…Genome-scale metabolic models (GEMs) are manually curated repositories describing the metabolic capabilities of an organism. GEMs have been successfully used…”
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A multi-platform flow device for microbial (co-) cultivation and microscopic analysis
Published in PloS one (14-05-2012)“…Novel microbial cultivation platforms are of increasing interest to researchers in academia and industry. The development of materials with specialized…”
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Toolkit for Visualization of the Cellular Structure and Organelles in Aspergillus niger
Published in ACS synthetic biology (19-12-2014)“…Aspergillus niger is a filamentous fungus that is extensively used in industrial fermentations for protein expression and the production of organic acids…”
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Comparison of 432 Pseudomonas strains through integration of genomic, functional, metabolic and expression data
Published in Scientific reports (06-12-2016)“…Pseudomonas is a highly versatile genus containing species that can be harmful to humans and plants while others are widely used for bioengineering and…”
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Comparative proteomics of Rhizopus delemar ATCC 20344 unravels the role of amino acid catabolism in fumarate accumulation
Published in PeerJ (San Francisco, CA) (30-03-2017)“…The filamentous fungus naturally accumulates relatively high amounts of fumarate. Although the culture conditions that increase fumarate yields are well…”
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Metabolic Modeling to Understand and Redesign Microbial Systems
Published 01-01-2017“…The goals of this thesis are to increase the understanding of microbial metabolism and to functionally (re-)design microbial systems using Genome- Scale…”
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Dissertation -
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A Multi-Platform Flow Device for Microbial
Published in PloS one (14-05-2012)“…Novel microbial cultivation platforms are of increasing interest to researchers in academia and industry. The development of materials with specialized…”
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Design and analysis of a tunable synchronized oscillator
Published in Journal of biological engineering (18-11-2013)“…The use of in silico simulations as a basis for designing artificial biological systems (and experiments to characterize them) is one of the tangible…”
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Erratum: Green genes: bioinformatics and systems-biology innovations drive algal biotechnology
Published in Trends in biotechnology (Regular ed.) (01-05-2015)“…Species Genome sizea (Mb) Available proteinsb Reported industrially relevant characteristicsa Refs Chlamydomonas reinhardtii 120 15 144 Model system for…”
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