Search Results - "van Groningen, Tim"

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma by van Groningen, Tim, Akogul, Nurdan, Westerhout, Ellen M., Chan, Alvin, Hasselt, Nancy E., Zwijnenburg, Danny A., Broekmans, Marloes, Stroeken, Peter, Haneveld, Franciska, Hooijer, Gerrit K. J., Savci-Heijink, C. Dilara, Lakeman, Arjan, Volckmann, Richard, van Sluis, Peter, Valentijn, Linda J., Koster, Jan, Versteeg, Rogier, van Nes, Johan

“…Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly…”
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Analysis of CRISPR‐Cas9 screens identifies genetic dependencies in melanoma by Christodoulou, Eirini, Rashid, Mamunur, Pacini, Clare, Droop, Alastair, Robertson, Holly, Groningen, Tim van, Teunisse, Amina F. A. S., Iorio, Francesco, Jochemsen, Aart G., Adams, David J., Doorn, Remco van

“…Targeting the MAPK signaling pathway has transformed the treatment of metastatic melanoma. CRISPR‐Cas9 genetic screens provide a genome‐wide approach to…”
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Neuroblastoma is composed of two super-enhancer-associated differentiation states by van Groningen, Tim, Koster, Jan, Valentijn, Linda J, Zwijnenburg, Danny A, Akogul, Nurdan, Hasselt, Nancy E, Broekmans, Marloes, Haneveld, Franciska, Nowakowska, Natalia E, Bras, Johannes, van Noesel, Carel J M, Jongejan, Aldo, van Kampen, Antoine H, Koster, Linda, Baas, Frank, van Dijk-Kerkhoven, Lianne, Huizer-Smit, Margriet, Lecca, Maria C, Chan, Alvin, Lakeman, Arjan, Molenaar, Piet, Volckmann, Richard, Westerhout, Ellen M, Hamdi, Mohamed, van Sluis, Peter G, Ebus, Marli E, Molenaar, Jan J, Tytgat, Godelieve A, Westerman, Bart A, van Nes, Johan, Versteeg, Rogier

“…Rogier Versteeg, Johan van Nes and colleagues report that neuroblastomas comprise two cell types, mesenchymal and adrenergic, that have different responses to…”
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A NOTCH3 Transcriptional Module Induces Cell Motility in Neuroblastoma by VAN NES, Johan, CHAN, Alvin, VAN GRONINGEN, Tim, VAN SLUIS, Peter, KOSTER, Jan, VERSTEEG, Rogier

“…Neuroblastoma is a childhood tumor of the peripheral sympathetic nervous system with an often lethal outcome due to metastatic disease. Migration and…”
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Therapeutic Strategies for Targeting CDKN2A Loss in Melanoma by Kreuger, Inger Z.M., Slieker, Roderick C., van Groningen, Tim, van Doorn, Remco

“…Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event driving melanoma progression. Therefore, therapeutic strategies aimed at…”
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Abstract SY24-02: Neuroblastoma: A developmental twist by Versteeg, Rogier, Valentijn, Linda, Koster, Jan, Groningen, Tim van, Hamdi, Mohamed, Westerhout, Ellen, Nes, Johan van

“…Abstract Intra-tumor heterogeneity is considered as a source of drug-resistant cells that can escape therapy and form relapses. Several tumor types display a…”
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Abstract IA10: Neuroblastoma is a biphasic tumor by Versteeg, Rogier, Groningen, Tim van, Koster, Jan, Valentijn, Linda J., Nes, Johan van

“…Abstract Neuroblastoma is a pediatric tumor of the peripheral adrenergic lineage, which is neural crest derived. During embryogenesis cells delaminate from the…”
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Abstract 3662: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors by Nes, Johan van, Groningen, Tim van, Valentijn, Linda, Zwijnenburg, Danny, Westerhout, Ellen M., Hamdi, Mohamed, Koster, Jan, Versteeg, Rogier

“…Abstract Background: Cellular identity in development and disease is driven by Core Regulatory Circuitries (CRCs) of lineage transcription factors that…”
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Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors by Westerhout, Ellen M, Hamdi, Mohamed, Stroeken, Peter, Nowakowska, Natalia E, Lakeman, Arjan, van Arkel, Jennemiek, Hasselt, Nancy E, Bleijlevens, Boris, Akogul, Nurdan, Haneveld, Franciska, Chan, Alvin, van Sluis, Peter, Zwijnenburg, Danny, Volckmann, Richard, van Noesel, Carel J M, Adameyko, Igor, van Groningen, Tim, Koster, Jan, Valentijn, Linda J, van Nes, Johan, Versteeg, Rogier

“…Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in…”
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Abstract 3876: Active enhancers delineate intra-tumor heterogeneity of developmental states in neuroblastoma by Nes, Johan van, Groningen, Tim van, Valentijn, Linda J., Zwijnenburg, Danny, Molenaar, Jan J., Westerman, Bart A., Westerhout, Ellen M., Hamdi, Mohamed, Tytgat, Godelieve A., Koster, Jan, Versteeg, Rogier

“…Abstract Background: Cellular heterogeneity within tumors is increasingly recognized as a source of therapeutic failure. However, the cis-regulatory landscapes…”
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Abstract PR08: Neuroblastoma is biphasic and includes classical neuroepithelial cells and chemoresistant mesenchymal cells by Versteeg, Rogier, Groningen, Tim van, Westerman, Bart A., Molenaar, Jan J., Westerhout, Ellen M., Hamdi, Mohamed, Tytgat, Godelieve A., Koster, Jan, Nes, Johan van

“…Abstract Introduction: Most high stage neuroblastoma initially respond to chemotherapy, but ultimately relapse as therapy-resistant tumor. The mechanisms…”
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Abstract LB-209: Neuroblastoma is biphasic with classical neuro-epithelial cells and chemoresistant mesenchymal cells controlled by PRRX1-NOTCH signaling by Groningen, Tim van, Nowakowska, Natalia E., Akogul, Nurdan, Broekmans, Marloes, Bras, Johannes, Booij, Jan, Ebus, Marli E., Molenaar, Jan J., Westerhout, Ellen M., Hamdi, Mohamed, Sluis, Peter van, Koster, Jan, Westerman, Bart A., Tytgat, Godelieve A., Versteeg, Rogier, Nes, Johan van

“…Abstract Most high stage neuroblastoma initially respond to chemotherapy, but ultimately relapse as therapy-resistant tumor. The mechanisms driving relapse and…”
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Abstract 2453: Neuroblastoma is bi-phasic and includes classical neuro-epithelial cells and chemo-resistant mesenchymal cells by Versteeg, Rogier, Groningen, Tim van, Valentijn, Linda J., Westerman, Bart A., Molenaar, Jan J., Westerhout, Ellen M., Hamdi, Mohamed, Tytgat, Godelieve A., Koster, Jan, Nes, Johan van

“…Abstract Introduction Most high stage neuroblastoma initially respond to chemotherapy, but ultimately relapse as therapy-resistant tumor. The mechanisms…”
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Mutation spectrum and pathway signatures mark neuroblastoma cells reflecting multiple developmental stages by Versteeg, Rogier, van Groningen, Tim, Molenaar, Jan, Westerman, Bart, Koster, Jan, van Nes, Johan

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