Search Results - "van Gorp, Patrick J."

Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells by Bieghs, Veerle, Verheyen, Fons, van Gorp, Patrick J, Hendrikx, Tim, Wouters, Kristiaan, Lütjohann, Dieter, Gijbels, Marion J J, Febbraio, Maria, Binder, Christoph J, Hofker, Marten H, Shiri-Sverdlov, Ronit

“…Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation, which can further progress into fibrosis and cirrhosis. Recently, we…”
Get full text

Specific immunization strategies against oxidized low-density lipoprotein: A novel way to reduce nonalcoholic steatohepatitis in mice by Bieghs, Veerle, van Gorp, Patrick J., Walenbergh, Sofie M.A., Gijbels, Marion J., Verheyen, Fons, Buurman, Wim A., Briles, David E., Hofker, Marten H., Binder, Christoph J., Shiri-Sverdlov, Ronit

“…Nonalcoholic steatohepatitis (NASH) is characterized by hepatic lipid accumulation combined with inflammation, which can ultimately progress into cirrhosis…”
Get full text

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice by Wouters, Kristiaan, Bilsen, Marc van, Gorp, Patrick J. van, Bieghs, Veerle, Lütjohann, Dieter, Kerksiek, Anja, Staels, Bart, Hofker, Marten H., Shiri-Sverdlov, Ronit

“…Hepatic inflammation is the key factor in non-alcoholic steatohepatitis (NASH) and promotes progression to liver damage. We recently identified dietary…”
Get full text

Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans by Plat, Jogchum, Hendrikx, Tim, Bieghs, Veerle, Jeurissen, Mike L J, Walenbergh, Sofie M A, van Gorp, Patrick J, De Smet, Els, Konings, Maurice, Vreugdenhil, Anita C E, Guichot, Yasmin Dias, Rensen, Sander S, Buurman, Wim A, Greve, Jan Willem M, Lütjohann, Dieter, Mensink, Ronald P, Shiri-Sverdlov, Ronit

“…The inflammatory component of non-alcoholic steatohepatitis (NASH) can lead to irreversible liver damage. Therefore there is an urgent need to identify novel…”
Get full text

Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice by Hendrikx, Tim, Bieghs, Veerle, Walenbergh, Sofie M A, van Gorp, Patrick J, Verheyen, Fons, Jeurissen, Mike L J, Steinbusch, Mandy M F, Vaes, Nathalie, Binder, Christoph J, Koek, Ger H, Stienstra, Rinke, Netea, Mihai G, Hofker, Marten H, Shiri-Sverdlov, Ronit

“…While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are…”
Get full text

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis by Wouters, Kristiaan, van Gorp, Patrick J., Bieghs, Veerle, Gijbels, Marion J., Duimel, Hans, Lütjohann, Dieter, Kerksiek, Anja, van Kruchten, Roger, Maeda, Nobuyo, Staels, Bart, van Bilsen, Marc, Shiri‐Sverdlov, Ronit, Hofker, Marten H.

“…Nonalcoholic steatohepatitis (NASH) involves liver lipid accumulation (steatosis) combined with hepatic inflammation. The transition towards hepatic…”
Get full text

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease by Bieghs, Veerle, Van Gorp, Patrick J, Wouters, Kristiaan, Hendrikx, Tim, Gijbels, Marion J, van Bilsen, Marc, Bakker, Jaap, Binder, Christoph J, Lütjohann, Dieter, Staels, Bart, Hofker, Marten H, Shiri-Sverdlov, Ronit

“…Non-alcoholic steatohepatitis (NASH) involves steatosis combined with inflammation, which can progress into fibrosis and cirrhosis. Exploring the molecular…”
Get full text

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis by Hamers, Anouk A.J, Vos, Mariska, Rassam, Fadi, Marinković, Goran, Kurakula, Kondababu, van Gorp, Patrick J, de Winther, Menno P.J, Gijbels, Marion J.J, de Waard, Vivian, de Vries, Carlie J.M

“…RATIONALE:Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in human atherosclerotic lesions in macrophages, endothelial cells, T cells…”
Get full text

Role of Scavenger Receptor A and CD36 in Diet-Induced Nonalcoholic Steatohepatitis in Hyperlipidemic Mice by Bieghs, Veerle, Wouters, Kristiaan, van Gorp, Patrick J, Gijbels, Marion J.J, de Winther, Menno P.J, Binder, Christoph J, Lütjohann, Dieter, Febbraio, Maria, Moore, Kathryn J, van Bilsen, Marc, Hofker, Marten H, Shiri–Sverdlov, Ronit

“…Background & Aims Nonalcoholic steatohepatitis (NASH) is a disorder that consists of steatosis and hepatic inflammation. It is not known why only some people…”
Get full text

Cathepsin D regulates lipid metabolism in murine steatohepatitis by Houben, Tom, Oligschlaeger, Yvonne, Hendrikx, Tim, Bitorina, Albert V., Walenbergh, Sofie M. A., van Gorp, Patrick J., Gijbels, Marion J. J., Friedrichs, Silvia, Plat, Jogchum, Schaap, Frank G., Lütjohann, Dieter, Hofker, Marten H., Shiri-Sverdlov, Ronit

“…Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the…”
Get full text

Bone marrow‐specific caspase‐1/11 deficiency inhibits atherosclerosis development in Ldlr−/− mice by Hendrikx, Tim, Jeurissen, Mike L. J, Gorp, Patrick J, Gijbels, Marion J, Walenbergh, Sofie M. A, Houben, Tom, Gorp, Rick, Pöttgens, Chantal C, Stienstra, Rinke, Netea, Mihai G, Hofker, Marten H, Donners, Marjo M. P. C, Shiri‐Sverdlov, Ronit

“…Recent investigations have suggested that inflammasome activation plays an important role during atherosclerosis. Upon activation, the inflammasome induces…”
Get full text

Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation by Bieghs, Veerle, Walenbergh, Sofie M. A., Hendrikx, Tim, van Gorp, Patrick J., Verheyen, Fons, Olde Damink, Steven W., Masclee, Ad A., Koek, Ger H., Hofker, Marten H., Binder, Christoph J., Shiri-Sverdlov, Ronit

“…Background & Aims Non‐alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation. The transition from steatosis towards NASH represents a…”
Get full text

Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr −/− mice by Jeurissen, Mike L.J, Walenbergh, Sofie M.A, Houben, Tom, Gijbels, Marion J.J, Li, Jieyi, Hendrikx, Tim, Oligschlaeger, Yvonne, van Gorp, Patrick J, Binder, Christoph J, Donners, Marjo M.P.C, Shiri-Sverdlov, Ronit

“…Abstract Background and aims Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant…”
Get full text

Plasma cathepsin D levels: a novel tool to predict pediatric hepatic inflammation by Walenbergh, Sofie M A, Houben, Tom, Hendrikx, Tim, Jeurissen, Mike L J, van Gorp, Patrick J, Vreugdenhil, Anita C E, Adriaanse, Marlou P, Buurman, Wim A, Hofker, Marten H, Mosca, Antonella, Lindsey, Patrick J, Alisi, Anna, Liccardo, Daniela, Panera, Nadia, Koek, Ger H, Nobili, Valerio, Shiri-Sverdlov, Ronit

“…Nonalcoholic steatohepatitis (NASH) is the most severe form of a hepatic condition known as nonalcoholic fatty liver disease (NAFLD). NASH is histologically…”
Get full text

Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr−/− mice by Hendrikx, Tim, Jeurissen, Mike L.J, Bieghs, Veerle, Walenbergh, Sofie M.A, van Gorp, Patrick J, Verheyen, Fons, Houben, Tom, Guichot, Yasmin Dias, Gijbels, Marion J.J, Leitersdorf, Eran, Hofker, Marten H, Lütjohann, Dieter, Shiri-Sverdlov, Ronit

“…Graphical abstract…”
Get full text

Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women by van Vliet-Ostaptchouk, Jana V, Onland-Moret, N Charlotte, Shiri-Sverdlov, Ronit, van Gorp, Patrick J J, Custers, Anne, Peeters, Petra H M, Wijmenga, Cisca, Hofker, Marten H, van der Schouw, Yvonne T

“…The TUB gene, encoding an evolutionary conserved protein, is highly expressed in the hypothalamus and might act as a transcription factor. Mutations in TUB…”
Get full text

SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production by Franke, Katka, Pillai, Saravanan Y, Hoogenboezem, Mark, Gijbels, Marion J J, Matlung, Hanke L, Geissler, Judy, Olsman, Hugo, Pottgens, Chantal, van Gorp, Patrick J, Ozsvar-Kozma, Maria, Saito, Yasuyuki, Matozaki, Takashi, Kuijpers, Taco W, Hendriks, Rudi W, Kraal, Georg, Binder, Christoph J, de Winther, Menno P J, van den Berg, Timo K

“…The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an…”
Get full text

Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates by Shiri-Sverdlov, Ronit, Wouters, Kristiaan, Gorp, Patrick J. van, Gijbels, Marion J., Noel, Benoit, Buffat, Laurent, Staels, Bart, Maeda, Nobuyo, Bilsen, Marc van, Hofker, Marten H.

“…The molecular mechanisms leading to Non-Alcoholic Steatohepatitis (NASH) are not fully understood. In mice, NASH can be inhibited by fenofibrate, a synthetic…”
Get full text

Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model by Li, Jieyi, Chanda, Dipanjan, van Gorp, Patrick J, Jeurissen, Mike L J, Houben, Tom, Walenbergh, Sofie M A, Debets, Jacques, Oligschlaeger, Yvonne, Gijbels, Marion J J, Neumann, Dietbert, Shiri-Sverdlov, Ronit

“…Non-alcoholic steatohepatitis (NASH) is a common liver disease characterized by hepatic lipid accumulation (steatosis) and inflammation. Currently, therapeutic…”
Get full text

Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet by Schröder, Katrin, Vecchione, Carmine, Jung, Oliver, Schreiber, Judith G., Shiri-Sverdlov, Ronit, van Gorp, Patrick J., Busse, Rudi, Brandes, Ralf P.

“…Hyperlipidemia enhances xanthine oxidase (XO) activity. XO is an important source of reactive oxygen species (ROS). Since ROS are thought to promote…”
Get full text