Search Results - "van Gorp, J P"

Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice by de Winther, Menno P.J., Gijbels, Marion J.J., van Dijk, Ko Willems, van Gorp, Patrick J.J., Suzuki, Hiroshi, Kodama, Tatsuhiko, Frants, Rune R., Havekes, Louis M., Hofker, Marten H.

“…Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the…”
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In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway by Jong, M C, Dahlmans, V E, van Gorp, P J, van Dijk, K W, Breuer, M L, Hofker, M H, Havekes, L M

“…To study the role of apoC1 in lipoprotein metabolism, we have generated transgenic mice expressing the human APOC1 gene. On a sucrose-rich diet, male…”
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Both Lipolysis and Hepatic Uptake of VLDL Are Impaired in Transgenic Mice Coexpressing Human Apolipoprotein E3Leiden and Human Apolipoprotein C1 by Jong, Miek C, Dahlmans, Vivian E.H, van Gorp, Patrick J.J, Breuer, Marco L, Mol, Marc J.T.M, van der Zee, Andre, Frants, Rune R, Hofker, Marten H, Havekes, Louis M

“…Transgenic mice overexpressing human APOE*3Leiden are highly susceptible to diet-induced hyperlipoproteinemia and atherosclerosis due to a defect in hepatic…”
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Double-blind comparison of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid suppositories in patients with idiopathic proctitis by van Hogezand, R A, van Hees, P A, van Gorp, J P, van Lier, H J, Bakker, J H, Wesseling, P, van Haelst, U J, van Tongeren, J H

“…Suppositories containing 300 mg 5-aminosalicylic acid (1.96 mmol) or 425 mg acetyl-5-aminosalicylic acid (1.96 mmol) were used in 40 patients with idiopathic…”
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Cathepsin D regulates lipid metabolism in murine steatohepatitis by Houben, Tom, Oligschlaeger, Yvonne, Hendrikx, Tim, Bitorina, Albert V., Walenbergh, Sofie M. A., van Gorp, Patrick J., Gijbels, Marion J. J., Friedrichs, Silvia, Plat, Jogchum, Schaap, Frank G., Lütjohann, Dieter, Hofker, Marten H., Shiri-Sverdlov, Ronit

“…Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the…”
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Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates by Shiri-Sverdlov, Ronit, Wouters, Kristiaan, Gorp, Patrick J. van, Gijbels, Marion J., Noel, Benoit, Buffat, Laurent, Staels, Bart, Maeda, Nobuyo, Bilsen, Marc van, Hofker, Marten H.

“…The molecular mechanisms leading to Non-Alcoholic Steatohepatitis (NASH) are not fully understood. In mice, NASH can be inhibited by fenofibrate, a synthetic…”
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Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice by Wouters, Kristiaan, Shiri-Sverdlov, Ronit, van Gorp, Patrick J, van Bilsen, Marc, Hofker, Marten H

“…Hyperlipidemia is the most important risk factor for atherosclerosis, which is the major cause of cardiovascular disease. The etiology of hyperlipidemia and…”
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Genomic analysis of the response of mouse models to high-fat feeding shows a major role of nuclear receptors in the simultaneous regulation of lipid and inflammatory genes by Kreeft, Arja J., Moen, Corina J.A., Porter, Gordon, Kasanmoentalib, Soemini, Sverdlov, Ronit, van Gorp, Patrick J., Havekes, Louis M., Frants, Rune R., Hofker, Marten H.

“…The mechanisms of diet induced hyperlipidemia and atherosclerosis have been widely studied by delineating the role of candidate genes in transgenic and gene…”
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In the Absence of Endogenous Mouse Apolipoprotein E, Apolipoprotein E2(Arg-158 → Cys) Transgenic Mice Develop More Severe Hyperlipoproteinemia than Apolipoprotein E3-Leiden Transgenic Mice by van Vlijmen, Bart J.M., van Dijk, Ko Willems, van't Hof, H. Belinda, van Gorp, Patrick J.J., van der Zee, André, van der Boom, Hans, Breuer, Marco L., Hofker, Marten H., Havekes, Louis M.

“…Apolipoprotein E*2(Arg-158 → Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3-Leiden (APOE*3-Leiden)…”
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