Minimal inhibitory concentration of omadacycline and doxycycline against bacterial isolates with known tetracycline resistance determinants

Omadacycline is an aminomethylcycline derived from the tetracycline class. The minimum inhibitory concentration of 115 Enterobacteriaceae and Staphylococcus aureus isolates with known tetracycline resistance determinants against omadacycline and doxycycline was determined by broth microdilution. Oma...

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Bibliographic Details
Published in:	Diagnostic microbiology and infectious disease Vol. 94; no. 1; pp. 78 - 80
Main Authors:	Fluit, Ad C., van Gorkum, Sjoukje, Vlooswijk, Judith
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-05-2019
Subjects:	Doxycycline MIC Omadacycline Resistance Resistance Omadacycline MIC Doxycycline
Online Access:	Get full text
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Summary:	Omadacycline is an aminomethylcycline derived from the tetracycline class. The minimum inhibitory concentration of 115 Enterobacteriaceae and Staphylococcus aureus isolates with known tetracycline resistance determinants against omadacycline and doxycycline was determined by broth microdilution. Omadacycline is, on a weight basis, more active than doxycycline for nearly all isolates, and differences in activity correlated with organism rather than resistance mechanism.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2018.11.010