Search Results - "van Gool, Willem"

Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial by van Charante, Eric P Moll, MD, Richard, Edo, MD, Eurelings, Lisa S, MD, van Dalen, Jan-Willem, MSc, Ligthart, Suzanne A, MD, van Bussel, Emma F, MD, Hoevenaar-Blom, Marieke P, PhD, Vermeulen, Marinus, Prof, van Gool, Willem A, Prof

“…Summary Background Cardiovascular risk factors are associated with an increased risk of dementia. We assessed whether a multidomain intervention targeting…”
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Systemic infection and delirium: when cytokines and acetylcholine collide by van Gool, Willem A, Prof, van de Beek, Diederik, MD, Eikelenboom, Piet, Prof

“…Summary Systemic infection and drugs with anticholinergic effects are well-recognised and prevalent risk factors for delirium in elderly people. Experimental…”
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Systemic inflammation and microglial activation: systematic review of animal experiments by Hoogland, Inge C M, Houbolt, Carin, van Westerloo, David J, van Gool, Willem A, van de Beek, Diederik

“…Animal studies show that peripheral inflammatory stimuli may activate microglial cells in the brain implicating an important role for microglia in…”
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Apathy in Parkinson's disease: A systematic review and meta-analysis by den Brok, Melina G.H.E., van Dalen, Jan Willem, van Gool, Willem A., Moll van Charante, Eric P., de Bie, Rob M.A., Richard, Edo

“…Apathy is a frequently reported neuropsychiatric symptom in Parkinson's disease (PD), but its prevalence and clinical correlates are debated. We aimed to…”
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Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial by van Eijk, Maarten MJ, MD, Roes, Kit CB, Prof, Honing, Marina LH, MD, Kuiper, Michael A, MD, Karakus, Attila, MD, van der Jagt, Mathieu, MD, Spronk, Peter E, MD, van Gool, Willem A, Prof, van der Mast, Roos C, Prof, Kesecioglu, Jozef, Prof, Slooter, Arjen JC, Dr

“…Summary Background Delirium is frequently diagnosed in critically ill patients and is associated with adverse outcome. Impaired cholinergic neurotransmission…”
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Haloperidol Prophylaxis for Elderly Hip-Surgery Patients at Risk for Delirium: A Randomized Placebo-Controlled Study by Kalisvaart, Kees J., De Jonghe, Jos F. M., Bogaards, Marja J., Vreeswijk, Ralph, Egberts, Toine C. G., Burger, Bart J., Eikelenboom, Piet, Van Gool, Willem A.

“…Objectives: To study the effectiveness of haloperidol prophylaxis on incidence, severity, and duration of postoperative delirium in elderly hip‐surgery…”
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Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data by van Bussel, Emma F, Richard, Edo, Arts, Derk L, Nooyens, Astrid C J, Coloma, Preciosa M, de Waal, Margot W M, van den Akker, Marjan, Biermans, Marion C J, Nielen, Markus M J, van Boven, Kees, Smeets, Hugo, Matthews, Fiona E, Brayne, Carol, Busschers, Wim B, van Gool, Willem A, Moll van Charante, Eric P

“…Recent reports have suggested declining age-specific incidence rates of dementia in high-income countries over time. Improved education and cardiovascular…”
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Neuroinflammation in Alzheimer's disease wanes with age by Hoozemans, Jeroen J M, Rozemuller, Annemieke J M, van Haastert, Elise S, Eikelenboom, Piet, van Gool, Willem A

“…Inflammation is a prominent feature in Alzheimer's disease (AD). It has been proposed that aging has an effect on the function of inflammation in the brain,…”
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Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease by Eikelenboom, Piet, Hoozemans, Jeroen Jm, Veerhuis, Rob, van Exel, Eric, Rozemuller, Annemieke Jm, van Gool, Willem A

“…Neuropathological studies have revealed the presence of a broad variety of inflammation-related proteins (complement factors, acute-phase proteins,…”
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Value of Neuropsychological Tests, Neuroimaging, and Biomarkers for Diagnosing Alzheimer's Disease in Younger and Older Age Cohorts by Schmand, Ben, Eikelenboom, Piet, van Gool, Willem A.

“…OBJECTIVES: To examine the influence of age on the value of four techniques for diagnosing Alzheimer's disease (AD). DESIGN: Observational cohort study…”
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Risk Factors and Prediction of Postoperative Delirium in Elderly Hip-Surgery Patients: Implementation and Validation of a Medical Risk Factor Model by Kalisvaart, Kees J., Vreeswijk, Ralph, De Jonghe, Jos F. M., Van Der Ploeg, Tjeerd, Van Gool, Willem A., Eikelenboom, Piet

“…OBJECTIVES: To evaluate risk factors for postoperative delirium in a cohort of elderly hip‐surgery patients and to validate a medical risk stratification…”
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Microglia activation in sepsis: a case-control study by Lemstra, Afina W, Groen in't Woud, Jacqueline C M, Hoozemans, Jeroen J M, van Haastert, Elise S, Rozemuller, Annemiek J M, Eikelenboom, Piet, van Gool, Willem A

“…Infection induces an acute phase response that is accompanied by non-specific symptoms collectively named sickness behavior. Recent observations suggest that…”
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Human prion diseases in the Netherlands (1998-2009): clinical, genetic and molecular aspects by Jansen, Casper, Parchi, Piero, Capellari, Sabina, Ibrahim-Verbaas, Carla A, Schuur, Maaike, Strammiello, Rosaria, Corrado, Patrizia, Bishop, Matthew T, van Gool, Willem A, Verbeek, Marcel M, Baas, Frank, van Saane, Wesley, Spliet, Wim G M, Jansen, Gerard H, van Duijn, Cornelia M, Rozemuller, Annemieke J M

“…Prion diseases are rare and fatal neurodegenerative disorders that can be sporadic, inherited or acquired by infection. Based on a national surveillance…”
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Sex Differences in the Relation Between Subjective Memory Complaints, Impairments in Instrumental Activities of Daily Living, and Risk of Dementia by Abdulrahman, Herrer, Richard, Edo, van Gool, Willem A, Moll van Charante, Eric P, van Dalen, Jan Willem

“…Older people with subjective memory complaints (SMC) and Instrumental Activities of Daily Living impairments (IADL-I) have an increased risk of developing…”
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Unblinding in the lecanemab trial in Alzheimer’s disease by Van Gool, Willem A

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Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients by Westhoff, Dunja, Witlox, Joost, Koenderman, Leo, Kalisvaart, Kees J, de Jonghe, Jos F M, van Stijn, Mireille F M, Houdijk, Alexander P J, Hoogland, Inge C M, Maclullich, Alasdair M J, van Westerloo, David J, van de Beek, Diederik, Eikelenboom, Piet, van Gool, Willem A

“…Aging and neurodegenerative disease predispose to delirium and are both associated with increased activity of the innate immune system resulting in an…”
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Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial by Richard, Edo, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Coley, Nicola, Barbera, Mariagnese, van der Groep, Abraham, Meiller, Yannick, Mangialasche, Francesca, Beishuizen, Cathrien B, Jongstra, Susan, van Middelaar, Tessa, Van Wanrooij, Lennard L, Ngandu, Tiia, Guillemont, Juliette, Andrieu, Sandrine, Brayne, Carol, Kivipelto, Miia, Soininen, Hilkka, Van Gool, Willem A

“…Although web-based interventions have been promoted for cardiovascular risk management over the past decade, there is limited evidence for effectiveness of…”
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Improving Prediction of Dementia in Primary Care by Jongstra, Susan, MD, PhD, Gool, Willem A. van, MD, PhD, Charante, Eric P. Moll van, MD, PhD, Dalen, Jan-Willem van, MSc, PhD, Eurelings, Lisa S.M., MD, PhD, Richard, Edo, MD, PhD, Ligthart, Suzanne A., MD, PhD

“…Abstract Purpose The Mini-Mental State Examination (MMSE) is one of the most widely used instruments to screen for cognitive deficits; however, this instrument…”
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Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease by Eikelenboom, Piet, van Exel, Erik, Hoozemans, Jeroen J M, Veerhuis, Rob, Rozemuller, Annemieke J M, van Gool, Willem A

“…About hundred years ago, Oskar Fischer proposed that the senile plaques are the consequence of the deposition of a foreign substance that could induce an…”
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Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coli by Hoogland, Inge C M, Westhoff, Dunja, Engelen-Lee, Joo-Yeon, Melief, Jeroen, Valls Serón, Mercedes, Houben-Weerts, Judith H M P, Huitinga, Inge, van Westerloo, David J, van der Poll, Tom, van Gool, Willem A, van de Beek, Diederik

“…Microglial activation after systemic infection has been suggested to mediate sepsis-associated delirium. A systematic review of animal studies suggested…”
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