Search Results - "van Golen, Rowan F"

Protective Mechanisms of Hypothermia in Liver Surgery and Transplantation by Olthof, Pim B, Reiniers, Megan J, Dirkes, Marcel C, Gulik, Thomas M van, Golen, Rowan F van

“…Hepatic ischemia/reperfusion (I/R) injury is a side effect of major liver surgery that often cannot be avoided. Prolonged periods of ischemia put a metabolic…”
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Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury by van Golen, Rowan F., van Gulik, Thomas M., Heger, Michal

“…Endothelial cells are covered by a delicate meshwork of glycoproteins known as the glycocalyx. Under normophysiological conditions the glycocalyx plays an…”
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Hypothermic perfusion with retrograde outflow during right hepatectomy is safe and feasible by Reiniers, Megan J., MD, Olthof, Pim. B., MD, van Golen, Rowan F., MD, Heger, Michal, PhD, van Beek, Adriaan A., PhD, Meijer, Ben, PhD, Leen, René, BS, van Kuilenburg, André B.P., PhD, Mearadji, Banafsche, MD, PhD, Bennink, Roelof J., MD, PhD, Verheij, Joanne, MD, PhD, van Gulik, Thomas M., MD, PhD

“…Background In situ hypothermic perfusion during liver resection performed under vascular inflow occlusion decreases hepatic ischemia-reperfusion injury, but…”
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Preparation and Practical Applications of 2′,7′-Dichlorodihydrofluorescein in Redox Assays by Reiniers, Megan J, van Golen, Rowan F, Bonnet, Sylvestre, Broekgaarden, Mans, van Gulik, Thomas M, Egmond, Maarten R, Heger, Michal

“…Oxidative stress, a state in which intra- or extracellular oxidant production outweighs the antioxidative capacity, lies at the basis of many diseases…”
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Sterile inflammation in hepatic ischemia/reperfusion injury: Present concepts and potential therapeutics by van Golen, Rowan F, Reiniers, Megan J, Olthof, Pim B, van Gulik, Thomas M, Heger, Michal

“…Ischemia and reperfusion (I/R) injury is an often unavoidable consequence of major liver surgery and is characterized by a sterile inflammatory response that…”
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The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury by van Golen, Rowan F, Reiniers, Megan J, Vrisekoop, Nienke, Zuurbier, Coert J, Olthof, Pim B, van Rheenen, Jacco, van Gulik, Thomas M, Parsons, Barry J, Heger, Michal

“…Hepatic ischemia/reperfusion (I/R) injury is an inevitable side effect of major liver surgery that can culminate in liver failure. The bulk of I/R-induced…”
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Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury by Olthof, Pim B., van Golen, Rowan F., Meijer, Ben, van Beek, Adriaan A., Bennink, Roelof J., Verheij, Joanne, van Gulik, Thomas M., Heger, Michal

“…Hepatic ischemia/reperfusion (I/R) injury is characterized by hepatocellular damage, sterile inflammation, and compromised postoperative liver function…”
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The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion by van Golen, Rowan F., Reiniers, Megan J., Marsman, Gerben, Alles, Lindy K., van Rooyen, Derrick M., Petri, Björn, Van der Mark, Vincent A., van Beek, Adriaan A., Meijer, Ben, Maas, Martinus A., Zeerleder, Sacha, Verheij, Joanne, Farrell, Geoffrey C., Luken, Brenda M., Teoh, Narci C., van Gulik, Thomas M., Murphy, Michael P., Heger, Michal

“…Activation of sterile inflammation after hepatic ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with mitochondrial…”
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Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox Status by de Haan, Lianne R., Reiniers, Megan J., Reeskamp, Laurens F., Belkouz, Ali, Ao, Lei, Cheng, Shuqun, Ding, Baoyue, van Golen, Rowan F., Heger, Michal

“…Oxidative stress has been causally linked to various diseases. Electron transport chain (ETC) inhibitors such as rotenone and antimycin A are frequently used…”
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Analysis and Optimization of Conditions for the Use of 2',7'-Dichlorofluorescein Diacetate in Cultured Hepatocytes by Reiniers, Megan J, de Haan, Lianne R, Reeskamp, Laurens F, Broekgaarden, Mans, van Golen, Rowan F, Heger, Michal

“…Numerous liver pathologies encompass oxidative stress as molecular basis of disease. The use of 2',7'-dichlorodihydrofluorescein-diacetate (DCFH -DA) as…”
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Acute Liver Injury and Acute Liver Failure following Bariatric Surgery by van Golen, Rowan F., de Waard, Nadine E., Moolenaar, Laura R., Inderson, Akin, Crobach, Stijn, Langers, Alexandra M.J., van Hoek, Bart, Tushuizen, Maarten E.

“…Abstract Bariatric surgery is the most effective treatment for obesity and improves several manifestations of the metabolic syndrome, including nonalcoholic…”
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How much ischemia can the liver tolerate during resection? by van Riel, Wouter G., van Golen, Rowan F., Reiniers, Megan J., Heger, Michal, van Gulik, Thomas M.

“…The use of vascular inflow occlusion (VIO, also known as the Pringle maneuver) during liver surgery prevents severe blood loss and the need for blood…”
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Unaltered Liver Regeneration in Post-Cholestatic Rats Treated with the FXR Agonist Obeticholic Acid by de Haan, Lianne R, Verheij, Joanne, van Golen, Rowan F, Horneffer-van der Sluis, Verena, Lewis, Matthew R, Beuers, Ulrich H W, van Gulik, Thomas M, Olde Damink, Steven W M, Schaap, Frank G, Heger, Michal, Olthof, Pim B

“…In a previous study, obeticholic acid (OCA) increased liver growth before partial hepatectomy (PHx) in rats through the bile acid receptor farnesoid X-receptor…”
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In Situ Hypothermic Perfusion with Retrograde Outflow During Right Hemihepatectomy: First Experiences with a New Technique by Reiniers, Megan J., MS, van Golen, Rowan F., MS, Heger, Michal, PhD, Mearadji, Banafsche, MD, PhD, Bennink, Roelof J., MD, PhD, Verheij, Joanne, MD, PhD, van Gulik, Thomas M., MD, PhD

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The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer by Heger, Michal, van Golen, Rowan F, Broekgaarden, Mans, Michel, Martin C

“…This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets…”
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Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers by Wiggers, Jimme K, van Golen, Rowan F, Verheij, Joanne, Dekker, Annemiek M, van Gulik, Thomas M, Heger, Michal

“…Extrahepatic cholestasis sensitizes the liver to ischemia/reperfusion (I/R) injury during surgery for perihilar cholangiocarcinoma. It is associated with…”
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Molecular Pathways Governing the Termination of Liver Regeneration by de Haan, Lianne R, van Golen, Rowan F, Heger, Michal

“…The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration…”
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The sterile immune response during hepatic ischemia/reperfusion by van Golen, Rowan F, van Gulik, Thomas M, Heger, Michal

“…Abstract Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial constituent yet poses a potentially lethal threat to the host. In…”
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Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver by Reiniers, Megan J, van Golen, Rowan F, van Gulik, Thomas M, Heger, Michal

“…Hepatic ischemia-reperfusion (IR) injury results from the temporary deprivation of hepatic blood supply and is a common side effect of major liver surgery…”
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Finding fibroblast growth factor 19 during cholestasis: Does x mark the spot? by de Haan, Lianne R., van Golen, Rowan F.

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