Search Results - "van Gent, Dik"

Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy by Ruigrok, Eline A. M., van Vliet, Nicole, Dalm, Simone U., de Blois, Erik, van Gent, Dik C., Haeck, Joost, de Ridder, Corrina, Stuurman, Debra, Konijnenberg, Mark W., van Weerden, Wytske M., de Jong, Marion, Nonnekens, Julie

“…Purpose Various radiolabeled prostate-specific membrane antigen (PSMA)–targeting tracers are clinically applied for prostate cancer (PCa) imaging and targeted…”
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Role of the DNA damage response in prostate cancer formation, progression and treatment by Zhang, Wenhao, van Gent, Dik C., Incrocci, Luca, van Weerden, Wytske M., Nonnekens, Julie

“…Background Clinical and preclinical studies have revealed that alterations in DNA damage response (DDR) pathways may play an important role in prostate cancer…”
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Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment by Ruigrok, Eline, Verkaik, Nicole, de Blois, Erik, de Ridder, Corrina, Stuurman, Debra, Roobol, Stefan, Van Gent, Dik, de Jong, Marion, Van Weerden, Wytske, Nonnekens, Julie

“…Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However,…”
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HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair by Sato, Koichi, Brandsma, Inger, van Rossum-Fikkert, Sari E, Verkaik, Nicole, Oostra, Anneke B, Dorsman, Josephine C, van Gent, Dik C, Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N

“…Abstract The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in…”
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Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner by Zelensky, Alex N, Schoonakker, Mascha, Brandsma, Inger, Tijsterman, Marcel, van Gent, Dik C, Essers, Jeroen, Kanaar, Roland

“…Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random…”
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Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity by Wang, Yu-Hsiu, Ho, Teresa L F, Hariharan, Anushya, Goh, Hui Chin, Wong, Yao Liang, Verkaik, Nicole S, Lee, May Yin, Tam, Wai Leong, van Gent, Dik C, Venkitaraman, Ashok R, Sheetz, Michael P, Lane, David P

“…SignificanceOur work focuses on the critical longstanding question of the nontranscriptional role of p53 in tumor suppression. We demonstrate here that…”
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Exploiting DNA repair defects for novel cancer therapies by van Gent, Dik C, Kanaar, Roland

“…Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed…”
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Dynamic Assembly of End-Joining Complexes Requires Interaction between Ku70/80 and XRCC4 by Mari, Pierre-Olivier, Florea, Bogdan I., Persengiev, Stephan P., Verkaik, Nicole S., Brüggenwirth, Hennie T., Modesti, Mauro, Giglia-Mari, Giuseppina, Bezstarosti, Karel, Demmers, Jeroen A. A., Luider, Theo M., Houtsmuller, Adriaan B., van Gent, Dik C.

“…DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the assembly of several proteins on DNA ends. Although biochemical studies…”
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Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder by van den Tempel, Nathalie, Naipal, Kishan A T, Raams, Anja, van Gent, Dik C, Franckena, Martine, Boormans, Joost L, Kanaar, Roland

“…Bladder cancer (urothelial carcinoma) is a common malignancy characterized by high recurrence rates and intense clinical follow-up, indicating the necessity…”
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Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair by Zhang, Wenhao, Liao, Chen-Yi, Chtatou, Hajar, Incrocci, Luca, van Gent, Dik, van Weerden, Wytske, Nonnekens, Julie

“…Androgen-deprivation therapy was shown to improve treatment outcome of external beam radiation therapy (EBRT) for locally advanced prostate cancer (PCa). DNA…”
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Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells by Roobol, Stefan J, van den Bent, Irene, van Cappellen, Wiggert A, Abraham, Tsion E, Paul, Maarten W, Kanaar, Roland, Houtsmuller, Adriaan B, van Gent, Dik C, Essers, Jeroen

“…High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET radiation types, probably a result of the condensed energy deposition…”
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Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment by Naipal, Kishan A T, Verkaik, Nicole S, Ameziane, Najim, van Deurzen, Carolien H M, Ter Brugge, Petra, Meijers, Matty, Sieuwerts, Anieta M, Martens, John W, O'Connor, Mark J, Vrieling, Harry, Hoeijmakers, Jan H J, Jonkers, Jos, Kanaar, Roland, de Winter, Johan P, Vreeswijk, Maaike P, Jager, Agnes, van Gent, Dik C

“…Poly(ADP-ribose) polymerase (PARP) inhibitors are promising targeted treatment options for hereditary breast tumors with a homologous recombination (HR)…”
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Tumor slice culture system to assess drug response of primary breast cancer by Naipal, Kishan A T, Verkaik, Nicole S, Sánchez, Humberto, van Deurzen, Carolien H M, den Bakker, Michael A, Hoeijmakers, Jan H J, Kanaar, Roland, Vreeswijk, Maaike P G, Jager, Agnes, van Gent, Dik C

“…The high incidence of breast cancer has sparked the development of novel targeted and personalized therapies. Personalization of cancer treatment requires…”
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In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies by Chatalic, Kristell L S, Konijnenberg, Mark, Nonnekens, Julie, de Blois, Erik, Hoeben, Sander, de Ridder, Corrina, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, van Gent, Dik C, Nock, Berthold A, Maina, Theodosia, van Weerden, Wytske M, de Jong, Marion

“…A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field of PCa…”
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Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib by Nonnekens, Julie, van Kranenburg, Melissa, Beerens, Cecile E M T, Suker, Mustafa, Doukas, Michael, van Eijck, Casper H J, de Jong, Marion, van Gent, Dik C

“…Metastases expressing tumor-specific receptors can be targeted and treated by binding of radiolabeled peptides (peptide receptor radionuclide therapy or PRRT)…”
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Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks by Uematsu, Naoya, Weterings, Eric, Yano, Ken-ichi, Morotomi-Yano, Keiko, Jakob, Burkhard, Taucher-Scholz, Gisela, Mari, Pierre-Olivier, van Gent, Dik C, Chen, Benjamin P.C, Chen, David J

“…The DNA-dependent protein kinase catalytic subunit (DNA-PKCS) plays an important role during the repair of DNA double-strand breaks (DSBs). It is recruited to…”
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Correction to: Role of the DNA damage response in prostate cancer formation, progression and treatment by Zhang, Wenhao, van Gent, Dik C., Incrocci, Luca, van Weerden, Wytske M., Nonnekens, Julie

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis by Brandsma, Inger, Sato, Koichi, van Rossum-Fikkert, Sari E., van Vliet, Nicole, Sleddens, Esther, Reuter, Marcel, Odijk, Hanny, van den Tempel, Nathalie, Dekkers, Dick H.W., Bezstarosti, Karel, Demmers, Jeroen A.A., Maas, Alex, Lebbink, Joyce, Wyman, Claire, Essers, Jeroen, van Gent, Dik C., Baarends, Willy M., Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N.

“…The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We…”
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Development of an Ex Vivo Functional Assay for Prediction of Irradiation Related Toxicity in Healthy Oral Mucosa Tissue by Pachler, Katrin S, Lauwers, Iris, Verkaik, Nicole S, Rovituso, Marta, van der Wal, Ernst, Mast, Hetty, Jonker, Brend P, Sewnaik, Aniel, Hardillo, Jose A, Keereweer, Stijn, Monserez, Dominiek, Kremer, Bernd, Koppes, Sjors, van den Bosch, Thierry P P, Verduijn, Gerda M, Petit, Steven, Sørensen, Brita S, van Gent, Dik C, Capala, Marta E

“…Radiotherapy in the head-and-neck area is one of the main curative treatment options. However, this comes at the cost of varying levels of normal tissue…”
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C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties by Inagawa, Takabumi, Wennink, Thomas, Lebbink, Joyce H G, Keijzers, Guido, Florea, Bogdan I, Verkaik, Nicole S, van Gent, Dik C

“…The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break…”
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