Utility scores for different health states related to depression: individual participant data analysis

Objectives Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for...

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Published in:	Quality of life research Vol. 26; no. 7; pp. 1649 - 1658
Main Authors:	Kolovos, Spyros, Bosmans, Judith E., van Dongen, Johanna M., van Esveld, Birre, Magai, Dorcas, van Straten, Annemieke, van der Feltz-Cornelis, Christina, van Steenbergen-Weijenburg, Kirsten M., Huijbregts, Klaas M., van Marwijk, Harm, Riper, Heleen, van Tulder, Maurits W.
Format:	Journal Article
Language:	English
Published:	Cham Springer 01-07-2017 Springer International Publishing Springer Nature B.V
Subjects:	Depression - diagnosis Female Health Health Status Indicators Humans Male Medicine Medicine & Public Health Mental depression Middle Aged Psychometrics - methods Public Health Quality of life Quality of Life - psychology Quality of Life Research Quantitative psychology REVIEW Sociology Surveys and Questionnaires EQ-5D Depression Utility scores SF-6D Multilevel analysis Quality-of-life
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Summary:	Objectives Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for various health states related to depression severity. Methods We gathered individual participant data from ten randomized controlled trials evaluating depression treatments. The UK EQ-5D and SF-6D tariffs were used to generate utility scores. We defined five health states that were proposed from American Psychiatric Association and National Institute for Clinical Excellence guidelines: remission, minor depression, mild depression, moderate depression, and severe depression. We performed multilevel linear regression analysis. Results We included 1629 participants in the analyses. The average EQ-5D utility scores for the five health states were 0.70 (95% CI 0.67-0.73) for remission, 0.62 (95% CI 0.58-0.65) for minor depression, 0.57 (95% CI 0.54-0.61) for mild depression, 0.52 (95%CI 0.49-0.56) for moderate depression, and 0.39 (95% CI 0.35-0.43) for severe depression. In comparison with the EQ-5D, the utility scores based on the SF-6D were similar for remission (EQ5D = 0.70 vs. SF-6D = 0.69), but higher for severe depression (EQ-5D = 0.39 vs. SF-6D = 0.55). Conclusions We observed statistically significant differences in utility scores between depression health states. Individuals with less severe depressive symptoms had on average statistically significant higher utility scores than individuals suffering from more severe depressive symptomatology. In the present study, EQ-5D had a larger range of values as compared to SF-6D.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23
ISSN:	0962-9343 1573-2649
DOI:	10.1007/s11136-017-1536-2