Search Results - "van Eijk, Patrick"

Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq by Dobbs, Felix M., van Eijk, Patrick, Fellows, Mick D., Loiacono, Luisa, Nitsch, Roberto, Reed, Simon H.

“…Understanding how breaks form and are repaired in the genome depends on the accurate measurement of the frequency and position of DNA double strand breaks…”
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USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication by Mackay, Hannah L., Stone, Helen R., Ronson, George E., Ellis, Katherine, Lanz, Alexander, Aghabi, Yara, Walker, Alexandra K., Starowicz, Katarzyna, Garvin, Alexander J., Van Eijk, Patrick, Koestler, Stefan A., Anthony, Elizabeth J., Piberger, Ann Liza, Chauhan, Anoop S., Conway-Thomas, Poppy, Vaitsiankova, Alina, Vijayendran, Sobana, Beesley, James F., Petermann, Eva, Brown, Eric J., Densham, Ruth M., Reed, Simon H., Dobbs, Felix, Saponaro, Marco, Morris, Joanna R.

“…Mammalian DNA replication relies on various DNA helicase and nuclease activities to ensure accurate genetic duplication, but how different helicase and…”
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UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools by Zhou, Zheng, Humphryes, Neil, van Eijk, Patrick, Waters, Raymond, Yu, Shirong, Kraehenbuehl, Rolf, Hartsuiker, Edgar, Reed, Simon H

“…Regulating gene expression programmes is a central facet of the DNA damage response. The Dun1 kinase protein controls expression of many DNA damage induced…”
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The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4 by den Dulk, Ben, van Eijk, Patrick, de Ruijter, Martina, Brandsma, Jourica A., Brouwer, Jaap

“…In the yeast Saccharomyces cerevisiae the Rad4-Rad23 complex is implicated in the initial damage recognition of the Nucleotide Excision Repair (NER) pathway…”
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Histone modification and chromatin remodeling during NER by Waters, Raymond, van Eijk, Patrick, Reed, Simon

“…•Nucleotide excision repair requires chromatin to be modified in order to access and repair DNA damage.•We describe a series of technical advances to enable…”
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To incise or not and where: SET-domain methyltransferases know by Yancoskie, Michelle N., Maritz, Corina, van Eijk, Patrick, Reed, Simon H., Naegeli, Hanspeter

“…The concept of the histone code posits that histone modifications regulate gene functions once interpreted by epigenetic readers. A well-studied case is…”
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Negative DNA supercoiling induces genome-wide Cas9 off-target activity by Newton, Matthew D., Losito, Marialucrezia, Smith, Quentin M., Parnandi, Nishita, Taylor, Benjamin J., Akcakaya, Pinar, Maresca, Marcello, van Eijk, Patrick, Reed, Simon H., Boulton, Simon J., King, Graeme A., Cuomo, Maria Emanuela, Rueda, David S.

“…CRISPR-Cas9 is a powerful gene-editing technology; however, off-target activity remains an important consideration for therapeutic applications. We have…”
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Nucleosome remodeling at origins of global genome-nucleotide excision repair occurs at the boundaries of higher-order chromatin structure by van Eijk, Patrick, Nandi, Shuvro Prokash, Yu, Shirong, Bennett, Mark, Leadbitter, Matthew, Teng, Yumin, Reed, Simon H

“…Repair of UV-induced DNA damage requires chromatin remodeling. How repair is initiated in chromatin remains largely unknown. We recently demonstrated that…”
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Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin by Yu, Shirong, Evans, Katie, van Eijk, Patrick, Bennett, Mark, Webster, Richard M, Leadbitter, Matthew, Teng, Yumin, Waters, Raymond, Jackson, Stephen P, Reed, Simon H

“…The rates at which lesions are removed by DNA repair can vary widely throughout the genome, with important implications for genomic stability. To study this,…”
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DNA replication initiation shapes the mutational landscape and expression of the human genome by Murat, Pierre, Perez, Consuelo, Crisp, Alastair, van Eijk, Patrick, Reed, Simon H, Guilbaud, Guillaume, Sale, Julian E

“…The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation…”
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Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms by van Eijk, Patrick, Teng, Yumin, Bennet, Mark R, Evans, Katie E, Powell, James R, Webster, Richard M, Reed, Simon H

“…The genetic information contained within the DNA molecule is highly susceptible to chemical and physical insult, caused by both endogenous and exogenous…”
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