Search Results - "van Dyck, Eric"

Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma by Fritah, Sabrina, Muller, Arnaud, Jiang, Wei, Mitra, Ramkrishna, Sarmini, Mohamad, Dieterle, Monika, Golebiewska, Anna, Ye, Tao, Van Dyck, Eric, Herold-Mende, Christel, Zhao, Zhongming, Azuaje, Francisco, Niclou, Simone P.

“…Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to…”
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RNAi/CRISPR Screens: from a Pool to a Valid Hit by Schuster, Anne, Erasimus, Hélène, Fritah, Sabrina, Nazarov, Petr V., van Dyck, Eric, Niclou, Simone P., Golebiewska, Anna

“…High-throughput genetic screens interfering with gene expression are invaluable tools to identify gene function and phenotype-to-genotype interactions…”
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Centromeric and ectopic assembly of CENP-A chromatin in health and cancer: old marks and new tracks by Sharma, Abhishek Bharadwaj, Dimitrov, Stefan, Hamiche, Ali, Van Dyck, Eric

“…Abstract The histone H3 variant CENP-A confers epigenetic identity to the centromere and plays crucial roles in the assembly and function of the kinetochore,…”
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Binding of double-strand breaks in DNA by human Rad52 protein by West, Stephen C, Dyck, Eric Van, Stasiak, Alicja Z, Stasiak, Andrzej

“…Double-strand breaks (DSBs) in DNA are caused by ionizing radiation. These chromosomal breaks can kill the cell unless repaired efficiently, and inefficient or…”
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Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas by Zhang, Lu, Fritah, Sabrina, Nazarov, Petr V, Kaoma, Tony, Van Dyck, Eric

“…By generating protein diversity, alternative splicing provides an important oncogenic pathway. Isocitrate dehydrogenase ( ) 1 and 2 mutations and 1p/19q…”
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G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms by MARCEL, Virginie, TRAN, Phong L. T, SAGNE, Charlotte, MARTEL-PLANCHE, Ghyslaine, VASLIN, Laurence, TEULADE-FICHOU, Marie-Paule, HALL, Janet, MERGNY, Jean-Louis, HAINAUT, Pierre, VAN DYCK, Eric

“…The tumor suppressor gene TP53, encoding p53, is expressed as several transcripts. The fully spliced p53 (FSp53) transcript encodes the canonical p53 protein…”
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Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas by Pinto, Lia, Baidarjad, Hanane, Entz-Werlé, Natacha, Van Dyck, Eric

“…Despite their low incidence, pediatric high-grade gliomas (pHGGs), including diffuse intrinsic pontine gliomas (DIPGs), are the leading cause of mortality in…”
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DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks by Pinto, Lia M, Pailas, Alexandros, Bondarchenko, Max, Sharma, Abhishek Bharadwaj, Neumann, Katrin, Rizzo, Anthony J, Jeanty, Céline, Nicot, Nathalie, Racca, Carine, Graham, Mindy K, Naughton, Catherine, Liu, Yaqun, Chen, Chun-Long, Meakin, Paul J, Gilbert, Nick, Britton, Sébastien, Meeker, Alan K, Heaphy, Christopher M, Larminat, Florence, Van Dyck, Eric

“…Maintaining chromatin integrity at the repetitive non-coding DNA sequences underlying centromeres is crucial to prevent replicative stress, DNA breaks and…”
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XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase by Sharma, Abhishek Bharadwaj, Erasimus, Hélène, Pinto, Lia, Caron, Marie-Christine, Gopaul, Diyavarshini, Peterlini, Thibaut, Neumann, Katrin, Nazarov, Petr V, Fritah, Sabrina, Klink, Barbara, Herold-Mende, Christel C, Niclou, Simone P, Pasero, Philippe, Calsou, Patrick, Masson, Jean-Yves, Britton, Sébastien, Van Dyck, Eric

“…Abstract Replication-associated single-ended DNA double-strand breaks (seDSBs) are repaired predominantly through RAD51-mediated homologous recombination (HR)…”
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A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value by Entz-Werlé, Natacha, Poidevin, Laetitia, Nazarov, Petr V., Poch, Olivier, Lhermitte, Benoit, Chenard, Marie Pierre, Burckel, Hélène, Guérin, Eric, Fuchs, Quentin, Castel, David, Noel, Georges, Choulier, Laurence, Dontenwill, Monique, Van Dyck, Eric

“…Background: Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in pediatric neuro-oncology, displaying frequent resistance to standard…”
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Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity by Scafidi, Andrea, Lind-Holm Mogensen, Frida, Campus, Eleonora, Pailas, Alexandros, Neumann, Katrin, Legrave, Nathalie, Bernardin, François, Pereira, Sandro L., Antony, Paul M.A., Nicot, Nathalie, Mittelbronn, Michel, Grünewald, Anne, Nazarov, Petr V., Poli, Aurélie, Van Dyck, Eric, Michelucci, Alessandro

“…Epidemiological studies suggest that metformin reduces the risk of developing several types of cancer, including gliomas, and improves the overall survival in…”
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Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia by Moussay, Etienne, Palissot, Valérie, Vallar, Laurent, Poirel, Hélène A, Wenner, Thomas, El Khoury, Victoria, Aouali, Nasséra, Van Moer, Kris, Leners, Bernadette, Bernardin, François, Muller, Arnaud, Cornillet-Lefebvre, Pascale, Delmer, Alain, Duhem, Caroline, Ries, Fernand, van Dyck, Eric, Berchem, Guy

“…Chronic lymphocytic leukemia (CLL) cells are often affected by genomic aberrations targeting key regulatory genes. Although fludarabine is the standard first…”
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The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade by El-Khoury, Victoria, Moussay, Etienne, Janji, Bassam, Palissot, Valérie, Aouali, Nasséra, Brons, Nicolaas H C, Van Moer, Kris, Pierson, Sandrine, Van Dyck, Eric, Berchem, Guy

“…Clinical trials have shown activity of the isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 in different hematologic malignancies. There are…”
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Binding of double-strand breaks in DNA by human Rad52 protein by Van Dyck, Eric, Stasiak, Alicja Z., Stasiak, Andrzej, West, Stephen C.

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The human Rad52 protein exists as a heptameric ring by Stasiak, Alicja Z., Larquet, Eric, Stasiak, Andrzej, Müller, Shirley, Engel, Andreas, Van Dyck, Eric, West, Stephen C., Egelman, Edward H.

“…The RAD52 epistasis group was identified in yeast as a group of genes required to repair DNA damaged by ionizing radiation [1]. Genetic evidence indicates that…”
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Bronchial airway gene expression in smokers with lung or head and neck cancer by Van Dyck, Eric, Nazarov, Petr V., Muller, Arnaud, Nicot, Nathalie, Bosseler, Manon, Pierson, Sandrine, Van Moer, Kris, Palissot, Valérie, Mascaux, Céline, Knolle, Ulrich, Ninane, Vincent, Nati, Romain, Bremnes, Roy M., Vallar, Laurent, Berchem, Guy, Schlesser, Marc

“…Cigarette smoking is the major cause of cancers of the respiratory tract, including non‐small cell lung cancer (NSCLC) and head and neck cancer (HNC). In order…”
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Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins by McIlwraith, Michael J, Van Dyck, Eric, Masson, Jean-Yves, Stasiak, Alicja Z, Stasiak, Andrzej, West, Stephen C

“…The human Rad51 recombinase is essential for the repair of double-strand breaks in DNA that occur in somatic cells after exposure to ionising irradiation, or…”
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Precise binding of single-stranded DNA termini by human RAD52 protein by Parsons, Carol A., Baumann, Peter, Van Dyck, Eric, West, Stephen C.

“…The human RAD52 protein, which exhibits a heptameric ring structure, has been shown to bind resected double strand breaks (DSBs), consistent with an early role…”
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The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51 by Masson, Jean-Yves, Davies, Adelina A., Hajibagheri, Nasser, Van Dyck, Eric, Benson, Fiona E., Stasiak, Alicja Z., Stasiak, Andrzej, West, Stephen C.

“…Eukaryotic cells encode two homologs of Escherichia coli RecA protein, Rad51 and Dmc1, which are required for meiotic recombination. Rad51, like E.coli RecA,…”
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Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing by Van Dyck, Eric, Stasiak, Alicja Z, Stasiak, Andrzej, West, Stephen C

“…Double‐strand breaks (DSBs) occur frequently during DNA replication. They are also caused by ionizing radiation, chemical damage or as part of the series of…”
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