Search Results - "van Dongen, William D"

Bioanalytical LC–MS/MS of protein-based biopharmaceuticals by van den Broek, Irene, Niessen, Wilfried M.A., van Dongen, William D.

“…•Overview of LC–MS/MS strategies for quantitative bioanalysis of proteins.•Main focus on improvements toward low picomolar quantification of protein…”
Get full text

LC-MS-based quantification of intact proteins: perspective for clinical and bioanalytical applications by van den Broek, Irene, van Dongen, William D

“…Bioanalytical LC-MS for protein quantification is traditionally based on enzymatic digestion of the target protein followed by absolute quantification of a…”
Get full text

Generic solid phase extraction–liquid chromatography–tandem mass spectrometry method for fast determination of drugs in biological fluids by Schellen, Anniek, Ooms, Bert, van de Lagemaat, Dick, Vreeken, Rob, van Dongen, William D

“…A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase…”
Get full text

Current State of Oligonucleotide Characterization Using Liquid Chromatography–Mass Spectrometry: Insight into Critical Issues by Sutton, J. Michael, Guimaraes, Guilherme J, Annavarapu, Vidya, van Dongen, William D, Bartlett, Michael G

“…As interests increase in oligonucleotide therapeutics, there has been a greater need for analytical techniques to properly analyze and quantitate these…”
Get full text

The Role of Fluorinated Alcohols as Mobile Phase Modifiers for LC-MS Analysis of Oligonucleotides by Basiri, Babak, van Hattum, Hilde, van Dongen, William D., Murph, Mandi M., Bartlett, Michael G.

“…Hexafluoroisopropanol (HFIP) has been widely used as an acidic modifier for mobile phases for liquid chromatography-mass spectrometry (LC-MS) analysis of…”
Get full text

Integrated hemolysis monitoring for bottom-up protein bioanalysis by Kleinnijenhuis, Anne J, van Holthoon, Frédérique L, van Dongen, William D

“…Hemolysis can result in analyte suppression or enhancement and it can affect the extraction efficiency and analyte stability. Triskelion developed an…”
Get full text

Quantitative bottom up analysis of infliximab in serum using protein A purification and integrated μLC-electrospray chip IonKey MS/MS technology by Kleinnijenhuis, Anne J, Ingola, Martha, Toersche, Jan H, van Holthoon, Frédérique L, van Dongen, William D

“…TNO Triskelion has applied its general workflow for the development of quantitative LC-MS methods for proteins in biological matrices to the quantification of…”
Get full text

Exploring the boundaries of bioanalytical quantitative LC–MS–MS by Lagerwerf, Fija M, van Dongen, William D, Steenvoorden, Ruud J.J.M, Honing, Maarten, Jonkman, Jan H.G

“…In this article, the boundaries of quantitative high-performance liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS) as a bioanalytical tool…”
Get full text

Bioanalytical LC-MS of therapeutic oligonucleotides by van Dongen, William D, Niessen, Wilfried M A

“…Therapeutic oligonucleotides (OGNTs) are important biopharmaceutical drugs for the future, due to their ability to selectively reduce or knockout the…”
Get more information

LC-MS systems for quantitative bioanalysis by van Dongen, William D, Niessen, Wilfried M A

“…LC-MS has become the method-of-choice in small-molecule drug bioanalysis (molecular mass <800 Da) and is also increasingly being applied as an alternative to…”
Get more information

Conference Report: Moving Forward Together: “We are Making Progress” by van Dongen, William D, Renfurm, Luuk C

Get full text

Identification of drug metabolites in human plasma or serum integrating metabolite prediction, LC-HRMS and untargeted data processing by Jacobs, Peter L, Ridder, Lars, Ruijken, Marco, Rosing, Hilde, Jager, Nynke Gl, Beijnen, Jos H, Bas, Richard R, van Dongen, William D

“…Comprehensive identification of human drug metabolites in first-in-man studies is crucial to avoid delays in later stages of drug development. We developed an…”
Get full text

Simultaneous determination of endogenous deoxynucleotides and phosphorylated nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cells using ion-pair liquid chromatography coupled to mass spectrometry by Coulier, Leon, van Kampen, Jeroen J. A., de Groot, Ronald, Gerritsen, Henk W., Bas, Richard C., van Dongen, William D., Brüll, Lars P., Luider, Theo M.

“…Nucleoside reverse transcriptase inhibitors (NRTIs) are activated intracellularly to their triphosphate (TP) form, which compete with endogenous…”
Get full text

Fast atom bombardment mass spectrometry of some lantibiotics by Lipták, M, Vékey, K, van Dongen, W D, Heerma, W

“…Four lantibiotics namely epidermin, gallidermin, lanthiopeptin and mersacidin, have been studied by fast atom bombardment mass spectrometry. The molecular ion…”
Get more information

Identification of a new genetic variant of bovine ß-casein using reversed-phase high-performance liquid chromatography and mass spectrometric analysis by Visser, Servaas, Slangen, Charles J., Lagerwerf, Fija M., Van Dongen, William D., Haverkamp, Johan

“…Various components of β-casein fraction from bovine milk were separated by preparative reversed-phase high-performance liquid chromatography (RP-HPLC). They…”
Get full text

Simultaneous determination of endogenous deoxynucleotides and phosphorylated nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cells using ion-pair liquid chromatography coupled to mass spectrometry: Biomarker Discovery by COULIER, Leon, VAN KAMPEN, Jeroen J. A, DE GROOT, Ronald, GERRITSEN, Henk W, BAS, Richard C, VAN DONGEN, William D, BRÜLL, Lars P, LUIDER, Theo M

Get full text

Conference report: moving forward together: "we are making progress" by van Dongen, William D, Renfurm, Luuk C

“…The 6th European Bioanalysis Forum Open Meeting 20-22 November 2013, Hesperia Tower Hotel, Barcelona, Spain At the 6th European Bioanalysis Forum Open Meeting,…”
Get more information

Identification of the active site histidine in Staphylococcus hyicus lipase using chemical modification and mass spectrometry by Boots, Jan-Willem P., van Dongen, William D., Verheij, Hubertus M., de Haas, Gerard H., Haverkamp, Johan, Slotboom, Arend J.

“…Staphylococcus hyicus lipase is a serine hydrolase. In order to identify the active site histidine of S hyicus lipase we have chemically modified S. hyicus…”
Get full text