Search Results - "van Dongen, Eric P"
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Intra-operative red blood cell transfusion and mortality after cardiac surgery
Published in BMC anesthesiology (04-05-2019)“…Anemia in cardiac surgery patients has been associated with poor outcomes. Transfusion of red blood cells during surgery is common practice for perioperative…”
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Preoperative frailty and chronic pain after cardiac surgery: a prospective observational study
Published in BMC anesthesiology (01-07-2022)“…Chronic pain after cardiac surgery, whether or not related to the operation, is common and has negative impact on health related quality of life (HRQL)…”
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3
Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients
Published in Clinical pharmacokinetics (01-11-2011)“…Background and Objectives: In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the…”
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4
The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery
Published in Pharmaceutical research (01-12-2015)“…Purpose Bariatric surgery is nowadays commonly applied as treatment for morbid obesity (BMI > 40 kg/m 2 ). As information about the effects of this procedure…”
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Midazolam Pharmacokinetics in Morbidly Obese Patients Following Semi-Simultaneous Oral and Intravenous Administration: A Comparison with Healthy Volunteers
Published in Clinical pharmacokinetics (01-10-2014)“…Background While in vitro and animal studies have shown reduced cytochrome P450 (CYP) 3A activity due to obesity, clinical studies in (morbidly) obese patients…”
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Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen
Published in Clinical pharmacokinetics (01-07-2016)“…Introduction Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is…”
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Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis
Published in Journal of antimicrobial chemotherapy (01-03-2014)“…As morbidly obese patients are prone to surgical site infections, adequate blood and subcutaneous tissue concentrations of prophylactic antibiotic agents…”
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Risk factors for chronic thoracic pain after cardiac surgery via sternotomy
Published in European journal of cardio-thoracic surgery (01-12-2011)“…Abstract Objective: This study examines the influence of patient demographics and peri- and postoperative (≪7 days) characteristics on the incidence of chronic…”
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Spinal Near-Infrared Spectroscopy Measurements During and After Thoracoabdominal Aortic Aneurysm Repair: A Pilot Study
Published in The Annals of thoracic surgery (01-04-2015)“…Background Near-infrared spectroscopy (NIRS) is a noninvasive technique that allows continuous monitoring of regional hemoglobin oxygen saturation (rS o2 ). We…”
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10
Advanced glycation end products for preoperative frailty screening in older cardiac surgery patients
Published in Journal of the American Geriatrics Society (JAGS) (01-08-2023)“…Background Advanced glycation end products (AGEs) are potential biomarkers of biological age. Skin Auto Fluorescence (SAF) can assess AGEs non‐invasively. We…”
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Preoperative frailty and outcome in patients undergoing radical cystectomy
Published in BJU international (01-09-2020)“…Objective To determine the value of preoperative frailty screening in predicting postoperative severe complications and 1‐year mortality in patients undergoing…”
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The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine‐treated patients undergoing a painful procedure after cardiac surgery
Published in British journal of clinical pharmacology (01-06-2013)“…Aims The catechol‐O‐methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain…”
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Population pharmacodynamic model for low molecular weight heparin nadroparin in morbidly obese and non-obese patients using anti-Xa levels as endpoint
Published in European journal of clinical pharmacology (2015)“…Purpose In absence of specific dosing guidelines, the optimal dose of low molecular weight heparins for thrombosis prophylaxis in morbidly obese patients (BMI…”
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Does Intraoperative Fibrinogen Affect Blood Loss or Transfusion Practice After Aortic Arch Surgery: A Prematurely Ended Randomized Trial
Published in Clinical and applied thrombosis/hemostasis (01-01-2022)“…Cardiovascular surgery is often complicated by significant bleeding due to perioperative coagulopathy. The effectiveness of treatment with fibrinogen…”
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Association of Plasma Fibrinogen and Thromboelastography With Blood Loss in Complex Cardiac Surgery
Published in Clinical and applied thrombosis/hemostasis (2021)“…Postoperative coagulopathic bleeding is common in cardiac surgery and is associated with increased morbidity and mortality. Ideally, real-time information on…”
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A Common Variant in ERBB4 Regulates GABA Concentrations in Human Cerebrospinal Fluid
Published in Neuropsychopharmacology (New York, N.Y.) (01-08-2012)“…The neuregulin 1 (NRG1) receptor ErbB4 is involved in the development of cortical inhibitory GABAergic circuits and NRG1-ErbB4 signaling has been implicated in…”
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Vitamin B-6 vitamers in human plasma and cerebrospinal fluid
Published in The American journal of clinical nutrition (01-08-2014)“…Vitamin B-6 comprises a group of 6 interrelated vitamers and is essential for numerous physiologic processes, including brain functioning. Genetic disorders…”
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Long-Term Follow-Up After Thoracoabdominal Aortic Aneurysm Repair
Published in The Annals of thoracic surgery (01-02-2007)“…Background Early mortality and morbidity after thoracoabdominal aortic aneurysm (TAAA) repair has been analyzed extensively; however, very few studies have…”
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Anti-Xa Levels 4 h After Subcutaneous Administration of 5,700 IU Nadroparin Strongly Correlate with Lean Body Weight in Morbidly Obese Patients
Published in Obesity surgery (01-05-2012)“…Background Morbidly obese patients (BMI > 40 kg/m 2 ) are at increased risk for venous thromboembolism, especially after surgery. Despite limited evidence,…”
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Comparative evaluation of atracurium dosed on ideal body weight vs. total body weight in morbidly obese patients
Published in British journal of clinical pharmacology (01-01-2011)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Different conflicting reports have been published for the use of atracurium in morbidly obese patients. Dosing of…”
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