Search Results - "van Den Mooter, G"

Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze–dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling by Van Eerdenbrugh, B., Froyen, L., Martens, J.A., Blaton, N., Augustijns, P., Brewster, M., Van den Mooter, G.

“…In order to improve the dissolution and absorption properties of loviride, a poorly soluble antiviral agent, sucrose co-freeze–dried nanopowders were prepared,…”
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Light scattering measurements on microemulsions: Estimation of droplet sizes by Goddeeris, C., Cuppo, F., Reynaers, H., Bouwman, W.G., Van den Mooter, G.

“…Different scattering methods were used as tools to assess the size of droplets in highly diluted microemulsions. These were obtained after dilution of a…”
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Potential of amorphous microporous silica for ibuprofen controlled release by Aerts, C.A., Verraedt, E., Depla, A., Follens, L., Froyen, L., Van Humbeeck, J., Augustijns, P., Van den Mooter, G., Mellaerts, R., Martens, J.A.

“…Amorphous microporous silica (AMS) xerogel materials were synthesized in an acid-catalyzed sol–gel process. The porosity of AMS was adapted by varying sol–gel…”
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Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions by Verheyen, S, Blaton, N, Kinget, R, Van den Mooter, G

“…Solid dispersion literature, describing the mechanism of dissolution of drug–polyethylene glycol dispersions, still shows some gaps; (A) only few studies…”
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Solution calorimetry as an alternative approach for dissolution testing of nanosuspensions by Kayaert, P., Li, B., Jimidar, I., Rombaut, P., Ahssini, F., Van den Mooter, G.

“…Solution calorimetry permits dissolution testing of fast dissolving dosage forms like nanosuspensions. The formulation of poorly soluble drugs as…”
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Improvement of the dissolution rate of artemisinin by means of supercritical fluid technology and solid dispersions by Van Nijlen, T, Brennan, K, Van den Mooter, G, Blaton, N, Kinget, R, Augustijns, P

“…The purpose of this study was to enhance the dissolution rate of artemisinin in order to improve the intestinal absorption characteristics. The effect of: (1)…”
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The fate of ritonavir in the presence of darunavir by Nguyen, D.N., Van den Mooter, G.

“…[Display omitted] This study was the first investigation into the potential of a fixed dose combination of ritonavir and darunavir in the form of dispersible…”
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Intestinal Absorption Enhancement of the Ester Prodrug Tenofovir Disoproxil Fumarate through Modulation of the Biochemical Barrier by Defined Ester Mixtures by VAN GELDER, J, DEFERME, S, NAESENS, L, DE CLERCQ, E, VAN DEN MOOTER, G, KINGET, R, AUGUSTIJNS, P

“…The effect of discrete esters and ester mixtures on the intestinal stability and absorption of tenofovir disoproxil fumarate (tenofovir DF, an…”
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PLGA nanoparticles and nanosuspensions with amphotericin B: Potent in vitro and in vivo alternatives to Fungizone and AmBisome by Van de Ven, H., Paulussen, C., Feijens, P.B., Matheeussen, A., Rombaut, P., Kayaert, P., Van den Mooter, G., Weyenberg, W., Cos, P., Maes, L., Ludwig, A.

“…This paper describes the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and nanosuspensions with the polyene antibiotic amphotericin…”
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Development of a liquid chromatographic assay for an anti-HIV tablet containing lamivudine, zidovudine and TMC278.HCL by Pendela, M., Van Gyseghem, E., Van den Mooter, G., Baert, L., Rosier, J., Hoogmartens, J., Adams, E.

“…A liquid chromatographic method was developed to analyse a tablet containing three anti-human immunodeficiency virus (HIV) compounds: lamivudine, zidovudine…”
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Use of azo polymers for colon-specific drug delivery by Van den Mooter, G, Maris, B, Samyn, C, Augustijns, P, Kinget, R

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Melting behavior of pure polyethylene glycol 6000 and polyethylene glycol 6000 in solid dispersions containing diazepam or temazepam: a DSC study by Verheyen, S, Augustijns, P, Kinget, R, Van den Mooter, G

“…The purpose of the present study was to investigate the melting behavior of polyethylene glycol 6000 (PEG 6000) as such as well as in solid dispersions…”
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Direct compression properties of melt-extruded isomalt by Ndindayino, F, Henrist, D, Kiekens, F, Van den Mooter, G, Vervaet, C, Remon, J.P

“…Isomalt, a sugar alcohol, was melt-extruded prior to compression in order to improve its tabletting properties. After fusion, crystalline isomalt was…”
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Eudragit E PO as a Complementary Material for Designing Oral Drug Delivery Systems with Controlled Release Properties: Comparative Evaluation of New Interpolyelectrolyte Complexes with Countercharged Eudragit L100 Copolymers by Moustafine, R. I, Bukhovets, A. V, Sitenkov, A. Y, Kemenova, V. A, Rombaut, P, Van den Mooter, G

“…The design of new interpolyelectrolyte complexes (IPEC) between countercharged polymers (Eudragit EPO (EPO) and Eudragit L100 (L100)) was investigated. The…”
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Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25 by Van den Mooter, G., Wuyts, M., Blaton, N., Busson, R., Grobet, P., Augustijns, P., Kinget, R.

“…The glass forming properties of ketoconazole were investigated using differential scanning calorimetry (DSC), by quench cooling liquid ketoconazole from T m+10…”
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Drug absorption studies of prodrug esters using the Caco-2 model: evaluation of ester hydrolysis and transepithelial transport by Augustijns, P, Annaert, P, Heylen, P, Van den Mooter, G, Kinget, R

“…The design of lipophilic ester prodrugs is a widely used approach to obtain enhanced oral delivery of poorly membrane permeable compounds. The present study…”
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Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations by Verhoeven, E., De Beer, T.R.M., Schacht, E., Van den Mooter, G., Remon, J.P., Vervaet, C.

“…Mini-matrices with release-sustaining properties were developed by hot-melt extrusion (diameter 3 mm, height 2 mm) using metoprolol tartrate as model drug…”
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Dissolution enhancement of the anti-HIV drug UC 781 by formulation in a ternary solid dispersion with TPGS 1000 and Eudragit E100 by Goddeeris, C., Willems, T., Houthoofd, K., Martens, J.A., Van den Mooter, G.

“…The present research deals with the improvement of the dissolution properties of the anti-HIV drug UC 781. A ternary solid dispersion consisting of a high…”
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Direct compression and moulding properties of co-extruded isomalt/drug mixtures by Ndindayino, F, Vervaet, C, Van den Mooter, G, Remon, J.P

“…Isomalt, a disaccharide alcohol was co-extruded with paracetamol or hydrochlorothiazide (HCT) in order to improve its tabletting properties. After extrusion,…”
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Correlation between digestion of the lipid phase of smedds and release of the anti-HIV drug UC 781 and the anti-mycotic drug enilconazole from smedds by Goddeeris, C., Coacci, J., Van den Mooter, G.

“…The present studies were conducted primarily to compare the drug release process of the anti-HIV drug UC781 from three different smedds to the smedds digestion…”
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