Search Results - "van Den Anker, John"

Impact of Obesity on Drug Metabolism and Elimination in Adults and Children by Brill, Margreke J. E., Diepstraten, Jeroen, van Rongen, Anne, van Kralingen, Simone, van den Anker, John N., Knibbe, Catherijne A. J.

“…The prevalence of obesity in adults and children is rapidly increasing across the world. Several general (patho)physiological alterations associated with…”
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A critical appraisal of safety data on dydrogesterone for the support of early pregnancy: a scoping review and meta-analysis by Katalinic, Alexander, Shulman, Lee P., Strauss, Jerome F., Garcia-Velasco, Juan A, Anker, John N. van den

“…No data support the suggestion that first-trimester dydrogesterone use increases the risk of fetal abnormalities; however, two low-quality retrospective…”
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Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir by Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella, den Anker, John N., Green, Dionna J., Burckart, Gilbert J., Best, Brookie M., Mirochnick, Mark, Capparelli, Edmund V., Dallmann, André

“…Pregnancy is associated with physiological changes that may impact drug pharmacokinetics (PK). The goals of this study were to build maternal‐fetal…”
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Current Use of mTOR Inhibitors for the Treatment of Subependymal Giant Cell Astrocytomas and Epilepsy in Patients with TSC by Jancic, Jasna, Duric, Vesna, Ivancevic, Nikola, Nikolic, Blazo, van den Anker, John N, Samardzic, Janko

“…The serine/threonine kinase mechanistic target of rapamycin (mTOR) is an important sensor of the cellular energy condition which, at the same time, represents…”
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Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review by Fjalstad, Jon Widding, Esaiassen, Eirin, Juvet, Lene Kristine, van den Anker, John N, Klingenberg, Claus

“…To systematically review the impact of antibiotic therapy in the neonatal period on changes in the gut microbiota and/or antibiotic resistance development…”
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Treating Pain in Preterm Infants: Moving from Opioids to Acetaminophen by van den Anker, John N., MD, PhD, Allegaert, Karel, MD, PhD

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Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach by Allegaert, Karel, Cosaert, Katrien, van den Anker, John N

“…To attain effective and safe pharmacotherapy in neonates, caregivers have to consider both the clinical characteristics of the newborn and the pharmacokinetic…”
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The Impact of Hypothermia on the Pharmacokinetics of Drugs Used in Neonates and Young Infants by Pokorna, P, Wildschut, E D, Vobruba, V, van den Anker, John N, Tibboel, D

“…Therapeutic hypothermia (HT) is frequently used in neonates with hypoxic-ischemic encephalopathy and young infants during cardiopulmonary bypass (CPB)…”
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Neonatal pain management: still in search for the Holy Grail by Allegaert, Karel, van den Anker, John N

“…Inadequate pain management but also inappropriate use of analgesics in early infancy has negative effects on neurodevelopmental outcome. As a consequence,…”
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Dosing Guidelines of Aminoglycosides in Neonates: A Balance Between Physiology and Feasibility by Allegaert, Karel, Cossey, Veerle, van den Anker, John N

“…Once daily dosing of aminoglycosides has been introduced and validated in non-neonatal patient cohorts. This is because aminoglycosides display peak…”
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Clinical Pharmacology of Frequently Used Intravenous Drugs During Bariatric Surgery in Adolescents by Vaughns, Janelle D, Ziesenitz, Victoria C, van den Anker, John N

“…Obesity represents one of the most important public health issues according to the World Health Organization. Additionally, in a recent National Health and…”
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Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief by Mian, Paola, Dallmann, André, van den Anker, John N, Tibboel, Dick, Allegaert, Karel

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Therapeutic Drug Monitoring of Antimicrobial Drugs in Neonates: An Opinion Article by Touw, Daan J., van den Anker, John N.

“…Neonatal infections are associated with high morbidity and mortality rates. Optimal treatment of these infections requires knowledge of neonatal pharmacology…”
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Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs by Van den Anker, John N., McCune, Susan, Annaert, Pieter, Baer, Gerri R., Mulugeta, Yeruk, Abdelrahman, Ramy, Wu, Kunyi, Krudys, Kevin M., Fisher, Jeffrey, Slikker, William, Chen, Connie, Burckart, Gilbert J., Allegaert, Karel

“…Drug dosing in neonates should be based on integrated knowledge concerning the disease to be treated, the physiological characteristics of the neonate, and the…”
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Pharmacokinetics of Intravenous Lorazepam in Pediatric Patients with and without Status Epilepticus by Chamberlain, James M., MD, Capparelli, Edmund V., PharmD, Brown, Kathleen M., MD, Vance, Cheryl W., MD, Lillis, Kathleen, MD, Mahajan, Prashant, MD, MPH, MBA, Lichenstein, Richard, MD, Stanley, Rachel M., MD, MHSA, Davis, Colleen O., MD, MPH, FAAP, FACEP, Gordon, Stephen, MD, Baren, Jill M., MD, MBE, FACEP, FAAP, van den Anker, John N., MD, PhD, FCP, FAAP

“…Objective To evaluate the single dose pharmacokinetics of an intravenous dose of lorazepam in pediatric patients treated for status epilepticus (SE) or with a…”
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A big thank you and a warm welcome by den Anker, John N.

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Neonatal Therapeutics: Time for a More Effective and Impactful Collaboration Between Neonatologists and Clinical Pharmacologists by den Anker, John N.

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Availability of Oral Formulations Labeled for Use in Young Children in Serbia, Germany and the USA by Bajcetic, Milica, Kearns, Gregory L, Jovanovic, Ida, Brajovic, Milan, van den Anker, John N

“…The paucity of marketed drug products that have been adequately studied in infants and children and subsequently, licensed (or labeled) for pediatric use has…”
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Off-Label Use of Drugs in Children by NEVILLE, Kathleen A

“…The passage of the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act has collectively resulted in an improvement in rational…”
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Characterizing dynamics of serum creatinine and creatinine clearance in extremely low birth weight neonates during the first 6 weeks of life by van Donge, Tamara, Allegaert, Karel, Gotta, Verena, Smits, Anne, Levtchenko, Elena, Mekahli, Djalila, van den Anker, John, Pfister, Marc

“…Background Characterizing the dynamics of serum creatinine concentrations (Scr) and associated creatinine clearance (CLcr) as a measure of kidney function in…”
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