Search Results - "van Delft, Frederik W"

Genetic and functional diversity of propagating cells in glioblastoma by Piccirillo, Sara G M, Colman, Sue, Potter, Nicola E, van Delft, Frederik W, Lillis, Suzanne, Carnicer, Maria-Jose, Kearney, Lyndal, Watts, Colin, Greaves, Mel

“…Glioblastoma (GBM) is a lethal malignancy whose clinical intransigence has been linked to extensive intraclonal genetic and phenotypic diversity and the common…”
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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia by Papaemmanuil, Elli, Rapado, Inmaculada, Li, Yilong, Potter, Nicola E, Wedge, David C, Tubio, Jose, Alexandrov, Ludmil B, Van Loo, Peter, Cooke, Susanna L, Marshall, John, Martincorena, Inigo, Hinton, Jonathan, Gundem, Gunes, van Delft, Frederik W, Nik-Zainal, Serena, Jones, David R, Ramakrishna, Manasa, Titley, Ian, Stebbings, Lucy, Leroy, Catherine, Menzies, Andrew, Gamble, John, Robinson, Ben, Mudie, Laura, Raine, Keiran, O'Meara, Sarah, Teague, Jon W, Butler, Adam P, Cazzaniga, Giovanni, Biondi, Andrea, Zuna, Jan, Kempski, Helena, Muschen, Markus, Ford, Anthony M, Stratton, Michael R, Greaves, Mel, Campbell, Peter J

“…Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias…”
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Selection of dormant cells during treatment of T-lineage lymphoblastic leukemia and CREB as a therapeutic target by Masic, Dino, Bell, Hayden, Van Delft, Frederik W, Irving, Julie Anne Elizabeth

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Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia by Shi, Yuzhe, Beckett, Melanie C, Blair, Helen J, Tirtakusuma, Ricky, Nakjang, Sirintra, Enshaei, Amir, Halsey, Christina, Vormoor, Josef, Heidenreich, Olaf, Krippner-Heidenreich, Anja, van Delft, Frederik W

“…T-cell Acute Lymphoblastic Leukemia (T-ALL) is frequently characterized by glucocorticoid (GC) resistance, which is associated with inferior outcomes, thus…”
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Hyperactive CREB subpopulations increase during therapy in pediatric B-lineage acute lymphoblastic leukemia by Masic, Dino, Fee, Kayleigh, Bell, Hayden, Case, Marian, Witherington, Gabby, Lansbury, Sophie, Ojeda-Garcia, Juan, McDonald, David, Schwab, Claire, Van Delft, Frederik W, Filby, Andrew, Irving, Julie Anne Elizabeth

“…Persistence of residual disease in acute lymphoblastic leukemia (ALL) during the initial stages of chemotherapy is associated with inferior survival. To better…”
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Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma by De Coninck, Stien, De Smedt, Renate, Lintermans, Beatrice, Reunes, Lindy, Kosasih, Hansen J, Reekmans, Alexandra, Brown, Lauren M, Van Roy, Nadine, Palhais, Bruno, Roels, Juliette, Van der Linden, Malaika, Van Dorpe, Jo, Ntziachristos, Panagiotis, Van Delft, Frederik W, Mansour, Marc R, Pieters, Tim, Lammens, Tim, De Moerloose, Barbara, De Bock, Charles E, Goossens, Steven, Van Vlierberghe, Pieter

“…T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematologic malignancies. Current treatment consists…”
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Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement by Bomken, Simon, Enshaei, Amir, Schwalbe, Edward C, Mikulasova, Aneta, Dai, Yunfeng, Zaka, Masood, Fung, Kent T M, Bashton, Matthew, Lim, Huezin, Jones, Lisa, Karataraki, Nefeli, Winterman, Emily, Ashby, Cody, Attarbaschi, Andishe, Bertrand, Yves, Bradtke, Jutta, Buldini, Barbara, Burke, G A Amos, Cazzaniga, Giovanni, Gohring, Gudrun, De Groot-Kruseman, Hesta A, Haferlach, Claudia, Nigro, Luca Lo, Parihar, Mayur, Plesa, Adriana, Seaford, Emma, Sonneveld, Edwin, Strehl, Sabine, Van der Velden, Vincent H J, Rand, Vikki, Hunger, Stephen P, Harrison, Christine J, Bacon, Chris M, Van Delft, Frederik W, Loh, Mignon L, Moppett, John, Vormoor, Josef, Walker, Brian A, Moorman, Anthony V, Russell, Lisa J

“…Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukemia (BCP-ALL) carries an immunoglobulin- MYC rearrangement (IG-MYC-r). This can…”
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Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia by van Delft, Frederik W., Horsley, Sharon, Colman, Sue, Anderson, Kristina, Bateman, Caroline, Kempski, Helena, Zuna, Jan, Eckert, Cornelia, Saha, Vaskar, Kearney, Lyndal, Ford, Anthony, Greaves, Mel

“…B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1) fusion has an overall good prognosis, but relapses occur, usually after…”
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Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia by Bell, Hayden L., Blair, Helen J., Singh, Mankaran, Moorman, Anthony V., Heidenreich, Olaf, van Delft, Frederik W., Lunec, John, Irving, Julie A. E.

“…Abstract Background Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to improve…”
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Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in mice by van der Weyden, Louise, Giotopoulos, George, Rust, Alistair G., Matheson, Louise S., van Delft, Frederik W., Kong, Jun, Corcoran, Anne E., Greaves, Mel F., Mullighan, Charles G., Huntly, Brian J., Adams, David J.

“…The t(12;21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is…”
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Complex Genomic Alterations and Gene Expression in Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21 by Strefford, Jon C., van Delft, Frederik W., Robinson, Hazel M., Worley, Helen, Yiannikouris, Olga, Selzer, Rebecca, Richmond, Todd, Hann, Ian, Bellotti, Tony, Raghavan, Manoj, Young, Bryan D., Saha, Vaskar, Harrison, Christine J.

“…We have previously identified a unique subtype of acute lymphoblastic leukemia (ALL) associated with a poor outcome and characterized by intrachromosomal…”
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Immunologically silent cancer clone transmission from mother to offspring by Isoda, Takeshi, Ford, Anthony M, Tomizawa, Daisuke, van Delft, Frederik W, De Castro, David Gonzalez, Mitsuiki, Norkio, Score, Joannah, Taki, Tomohiko, Morio, Tomohiro, Takagi, Masatoshi, Saji, Hiroh, Greaves, Mel, Mizutani, Shuki

“…Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very…”
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Genetic variegation of clonal architecture and propagating cells in leukaemia by Anderson, Kristina, Lutz, Christoph, van Delft, Frederik W., Bateman, Caroline M., Guo, Yanping, Colman, Susan M., Kempski, Helena, Moorman, Anthony V., Titley, Ian, Swansbury, John, Kearney, Lyndal, Enver, Tariq, Greaves, Mel

“…Little is known of the genetic architecture of cancer at the subclonal and single-cell level or in the cells responsible for cancer clone maintenance and…”
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Disease evolution and outcomes in familial AML with germline CEBPA mutations by Tawana, Kiran, Wang, Jun, Renneville, Aline, Bödör, Csaba, Hills, Robert, Loveday, Chey, Savic, Aleksandar, Van Delft, Frederik W., Treleaven, Jennifer, Georgiades, Panayiotis, Uglow, Elizabeth, Asou, Norio, Uike, Naokuni, Debeljak, Maruša, Jazbec, Janez, Ancliff, Philip, Gale, Rosemary, Thomas, Xavier, Mialou, Valerie, Döhner, Konstanze, Bullinger, Lars, Mueller, Beatrice, Pabst, Thomas, Stelljes, Matthias, Schlegelberger, Brigitte, Wozniak, Eva, Iqbal, Sameena, Okosun, Jessica, Araf, Shamzah, Frank, Anne-Katrine, Lauridsen, Felicia B., Porse, Bo, Nerlov, Claus, Owen, Carolyn, Dokal, Inderjeet, Gribben, John, Smith, Matthew, Preudhomme, Claude, Chelala, Claude, Cavenagh, Jamie, Fitzgibbon, Jude

“…In-depth molecular investigation of familial leukemia has been limited by the rarity of recognized cases. This study examines the genetic events initiating…”
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Fertility preservation knowledge, attitudes and intentions among children by proxy and adolescents with cancer by Panagiotopoulou, Nikoletta, van Delft, Frederik W, Stewart, Jane A

“…•Fertility is an important consideration for young cancer patients at the time of cancer diagnosis, with the majority (>90%) having positive attitudes towards…”
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Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia by Bell, Hayden L., Blair, Helen J., Jepson Gosling, Samantha J., Galler, Martin, Astley, Daniel, Moorman, Anthony V., Heidenreich, Olaf, Veal, Gareth J., van Delft, Frederik W., Lunec, John, Irving, Julie A. E.

“…Due to the rarity of TP53 mutations in acute lymphoblastic leukemia (ALL), p53 re-activation by antagonism of the p53-MDM2 interaction represents a potential…”
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Unusual relapse of low hypodiploid acute lymphoblastic leukaemia in a family with Li‐Fraumeni syndrome by Delft, Frederik W., Bailey, Simon, Skinner, Roderick, Shenton, Geoff, Carey, Peter, Campbell‐Hewson, Quentin, Hale, Juliet, McDonald, Leigh, Pearce, Kate, Martin, Richard, Robinson, Katrina, Cuthbert, Gavin

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Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL‐class fusion by Moorman, Anthony V., Schwab, Claire, Winterman, Emily, Hancock, Jerry, Castleton, Anna, Cummins, Michelle, Gibson, Brenda, Goulden, Nick, Kearns, Pam, James, Beki, Kirkwood, Amy A., Lancaster, Donna, Madi, Mabrouk, McMillan, Andrew, Motwani, Jayashree, Norton, Alice, O’Marcaigh, Aengus, Patrick, Katharine, Bhatnagar, Neha, Qureshi, Amrana, Richardson, Deborah, Stokley, Simone, Taylor, Gordon, Delft, Frederik W., Moppett, John, Harrison, Christine J., Samarasinghe, Sujith, Vora, Ajay

“…Patients with an ABL‐class fusion have a high risk of relapse on standard chemotherapy but are sensitive to tyrosine kinase inhibitors (TKI). In UKALL2011, we…”
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RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia by Matthijssens, Filip, Sharma, Nitesh D, Nysus, Monique, Nickl, Christian K, Kang, Huining, Perez, Dominique R, Lintermans, Beatrice, Van Loocke, Wouter, Roels, Juliette, Peirs, Sofie, Demoen, Lisa, Pieters, Tim, Reunes, Lindy, Lammens, Tim, De Moerloose, Barbara, Van Nieuwerburgh, Filip, Deforce, Dieter L, Cheung, Laurence C, Kotecha, Rishi S, Risseeuw, Martijn Dp, Van Calenbergh, Serge, Takarada, Takeshi, Yoneda, Yukio, van Delft, Frederik W, Lock, Richard B, Merkley, Seth D, Chigaev, Alexandre, Sklar, Larry A, Mullighan, Charles G, Loh, Mignon L, Winter, Stuart S, Hunger, Stephen P, Goossens, Steven, Castillo, Eliseo F, Ornatowski, Wojciech, Van Vlierberghe, Pieter, Matlawska-Wasowska, Ksenia

“…T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that…”
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The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia by Furness, Caroline L, Mansur, Marcela B, Weston, Victoria J, Ermini, Luca, van Delft, Frederik W, Jenkinson, Sarah, Gale, Rosemary, Harrison, Christine J, Pombo-de-Oliveira, Maria S, Sanchez-Martin, Marta, Ferrando, Adolfo A, Kearns, Pamela, Titley, Ian, Ford, Anthony M, Potter, Nicola E, Greaves, Mel

“…Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1 + T-ALL. Single-cell multicolour FISH was…”
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