Search Results - "van Dam, Karel"

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations by Oliver, Stephen G, Raamsdonk, Léonie M, Teusink, Bas, Broadhurst, David, Zhang, Nianshu, Hayes, Andrew, Walsh, Michael C, Berden, Jan A, Brindle, Kevin M, Kell, Douglas B, Rowland, Jem J, Westerhoff, Hans V, van Dam, Karel

“…A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae, and of those sequenced in other organisms, encode proteins of unknown…”
Get full text

A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH by de Koning, W, van Dam, K

“…Glucose metabolism in yeast can be stopped within 0.1 s by spraying the cells in 60% methanol at -40 degrees C. With this procedure the integrity of the cells…”
Get more information

Intracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50 by Teusink, B, Diderich, J.A, Westerhoff, H.V, Dam, K. van, Walsh, M.C

“…In Saccharomyces cerevisiae cells exhibiting high-affinity glucose transport, the glucose consumption rate at extracellular concentrations above 10 mM was only…”
Get full text

Functional analysis of the hexose transporter homologue HXT5 in Saccharomyces cerevisiae by Diderich, Jasper A., Merijn Schuurmans, J., Van Gaalen, Monique C., Kruckeberg, Arthur L., Van Dam, Karel

“…The HXT5 gene encodes a functional hexose transporter that has moderate affinity for glucose (Km=10 mM), moderate to low affinity for fructose (Km=40 mM) and…”
Get full text

Physiological Properties of Saccharomyces cerevisiae from Which Hexokinase II Has Been Deleted by DIDERICH, Jasper A, RAAMSDONK, Léonie M, KRUCKEBERG, Arthur L, BERDEN, Jan A, VAN DAM, Karel

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Expression and activity of the Hxt7 high‐affinity hexose transporter of Saccharomyces cerevisiae by Ye, Ling, Berden, Jan A., van Dam, Karel, Kruckeberg, Arthur L.

“…High‐affinity hexose transport is required for efficient utilization of low hexose concentrations by the baker's yeast Saccharomyces cerevisiae. These low…”
Get full text

Growth and glucose repression are controlled by glucose transport in Saccharomyces cerevisiae cells containing only one glucose transporter by Ye, L, Kruckeberg, A.L, Berden, J.A, Dam, K. van

“…A set of Saccharomyces cerevisiae strains with variable expression of only the high-affinity Hxt7 glucose transporter was constructed by partial deletion of…”
Get full text

Hexokinase regulates kinetics of glucose transport and expression of genes encoding hexose transporters in Saccharomyces cerevisiae by Petit, T, Diderich, J A, Kruckeberg, A L, Gancedo, C, Van Dam, K

“…Glucose transport kinetics and mRNA levels of different glucose transporters were determined in Saccharomyces cerevisiae strains expressing different sugar…”
Get full text

Catabolite repression by glucose 6‐phosphate, gluconate and lactose in Escherichia coli by Hogema, Boris M., Arents, Jos C., Inada, Toshifumi, Aiba, Hiroji, Van Dam, Karel, Postma, Pieter W.

“…While catabolite repression by glucose has been studied extensively and is understood in large detail in Enterobacteriaceae, catabolite repression by…”
Get full text

Acetaldehyde mediates the synchronization of sustained glycolytic oscillations in populations of yeast cells by Richard, P, Bakker, B.M, Teusink, B, Dam, K. van, Westerhoff, H.V

“…In the presence of cyanide, populations of yeast cells can exhibit sustained oscillations in the concentration of glycolytic metabolites, NADH and ATP. This…”
Get full text

Metabolic control analysis of the bc1 complex of Saccharomyces cerevisiae: effect on cytochrome c oxidase, respiration and growth rate by Boumans, H, Berden, J.A, Grivell, L.A, Dam, K. van

“…A number of strains varying in steady-state level of assembled bc1 complex were used to test the conclusions from inhibitor titration experiments with isolated…”
Get full text

Synchronized heat flux oscillations in yeast cell populations by Teusink, B, Larsson, C, Diderich, J, Richard, P, van Dam, K, Gustafsson, L, Westerhoff, H V

“…Microcalorimetry was adapted to the study of glycolytic oscillations in suspensions of intact yeast cells. A correction procedure was developed for the…”
Get full text

Inhibitory effect of Mg2+ on the protonophoric activity of palmitic acid by Shinohara, Y, Unami, A, Teshima, M, Nishida, H, van Dam, K, Terada, H

“…To discriminate whether fatty acids are uncouplers that cause acceleration of State-4 respiration, associated with a decrease in the protonmotive force, or…”
Get full text

Glucose Uptake Kinetics and Transcription of HXTGenes in Chemostat Cultures of Saccharomyces cerevisiae by Diderich, Jasper A., Schepper, Mike, van Hoek, Pim, Luttik, Marijke A.H., van Dijken, Johannes P., Pronk, Jack T., Klaassen, Paul, Boelens, Hans F.M., de Mattos, M. Joost Teixeira, van Dam, Karel, Kruckeberg, Arthur L.

“…The kinetics of glucose transport and the transcription of all 20 members of the HXT hexose transporter gene family were studied in relation to the steady…”
Get full text

Thermodynamic Efficiency of Microbial Growth is Low but Optimal for Maximal Growth Rate by Westerhoff, Hans V., Hellingwerf, Klaas J., Van Dam, Karel

“…Thermodynamic efficiency of microbial growth on substrates that are more oxidized than biomass approaches 24%. This is the theoretical value for a linear…”
Get full text

The danger of metabolic pathways with turbo design by Teusink, Bas, Walsh, Michael C, van Dam, Karel, Westerhoff, Hans V

“…Many catabolic pathways begin with an ATP-requiring activation step, after which further metabolism yields a surplus of ATP. Such a `turbo' principle is useful…”
Get full text

Slipping pumps or proton leaks in oxidative phosphorylation by van Dam, Karel, Shinohara, Yasuo, Unami, Akira, Yoshida, Kenji, Terada, Hiroshi

“…Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase…”
Get full text

Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae by Diderich, J.A, Schepper, M, Hoek, P. van, Luttik, M.A.H, Dijken, J.P. van, Pronk, J.T, Klaassen, P, Boelens, H.F.M, Mattos, M.J.T. de, Dam, K. van

“…The kinetics of glucose transport and the transcription of all 20 members of the HXT hexose transporter gene family were studied in relation to the steady…”
Get full text

Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry by Teusink, Bas, Passarge, Jutta, Reijenga, Corinne A., Esgalhado, Eugenia, van der Weijden, Coen C., Schepper, Mike, Walsh, Michael C., Bakker, Barbara M., van Dam, Karel, Westerhoff, Hans V., Snoep, Jacky L.

“…This paper examines whether the in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes…”
Get full text

On the mechanism of activation of the ATPase in chloroplasts by Bakker-Grunwald, T, van Dam, K

Get more information